DRSC/TRiP Functional Genomics Resources

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Protein Alignment ANKRD44 and AKR1

DIOPT Version :9

Sequence 1:NP_001354424.1 Gene:ANKRD44 / 91526 HGNCID:25259 Length:1074 Species:Homo sapiens
Sequence 2:NP_010550.1 Gene:AKR1 / 851857 SGDID:S000002672 Length:764 Species:Saccharomyces cerevisiae


Alignment Length:310 Identity:89/310 - (28%)
Similarity:150/310 - (48%) Gaps:58/310 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    27 LIHKTEDV---NTLDSEKRT--PLHVAA----FLGDA-EIIELLILSGARVNAKDNMWLTPLHRA 81
            ::::.|:|   :||.:|::|  |.:..:    .|||: ||..|..|                 :|
Yeast     1 MVNELENVPRASTLTNEEQTVDPSNNDSQEDISLGDSNEITSLASL-----------------KA 48

Human    82 VASRSEEAVQVLIKHSADVNARDKNWQTPL----HVAAANKAVKCAEVII--PLLSSVNVSDRGG 140
            :.|.:||.     ..:..||..|:..:.||    |.|.....:...:.:|  .||...|..|...
Yeast    49 IRSGNEEE-----SGNEQVNHNDEAEEDPLLTRYHTACQRGDLATVKEMIHGKLLEVNNDGDSTE 108

Human   141 R-TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRA-------LHWAAYMGHLDVVALLINHGA 197
            . |.||.|::|..:.:|:.|:::||::||      ||       |||||..|::.:|..|:.|||
Yeast   109 HITGLHWASINNRLSVVDFLVSQGADVNA------RAGALHATPLHWAARYGYVYIVDFLLKHGA 167

Human   198 EVTCKDKKGYTPLHAAASNGQINVVKHLL----NLG-VEIDEINVYGNTALHIACYNGQDAVVNE 257
            :.|..|.:|:..||.:.::..|.:|.::|    :.| ::||..:..|.|:|..|.|.|....|.|
Yeast   168 DPTMTDDQGFNLLHLSVNSSNIMLVLYVLFNVVSKGLLDIDCRDPKGRTSLLWAAYQGDSLTVAE 232

Human   258 LIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGK 307
            |:.:||::...:..||||||:........: |:.|:.:|||...::..||
Yeast   233 LLKFGASIKIADTEGFTPLHWGTVKGQPHV-LKYLIQDGADFFQKTDTGK 281

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANKRD44NP_001354424.1 ANK 1 7..36 2/11 (18%)
ANK 2 40..69 10/35 (29%)
ANK 3 73..102 5/28 (18%)
ANK 4 106..135 7/34 (21%)
ANK 5 139..168 9/29 (31%)
ANK 6 172..201 13/35 (37%)
ANK 7 205..234 8/33 (24%)
ANK 8 238..267 11/28 (39%)
ANK 9 271..301 11/29 (38%)
ANK 10 305..334 2/3 (67%)
ANK 11 338..367
ANK 13 422..451
ANK 14 455..484
ANK 15 488..516
ANK 16 549..579
ANK 17 584..613
ANK 18 617..646
ANK 19 651..680
ANK 20 687..716
ANK 21 720..749
ANK 22 753..782
ANK 23 789..818
ANK 24 821..850
ANK 25 856..885
ANK 26 889..919
ANK 27 923..952
ANK 28 959..988
AKR1NP_010550.1 ANK repeat 75..101 CDD:293786 5/25 (20%)
ANKYR 78..270 CDD:223738 61/198 (31%)
ANK repeat 103..140 CDD:293786 13/42 (31%)
ANK repeat 142..173 CDD:293786 12/30 (40%)
ANK repeat 213..244 CDD:293786 11/30 (37%)
ANK repeat 246..271 CDD:293786 8/25 (32%)
COG5273 363..725 CDD:227598
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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