DRSC/TRiP Functional Genomics Resources

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Protein Alignment ANKRD44 and MBP1

DIOPT Version :9

Sequence 1:NP_001354424.1 Gene:ANKRD44 / 91526 HGNCID:25259 Length:1074 Species:Homo sapiens
Sequence 2:NP_010227.1 Gene:MBP1 / 851503 SGDID:S000002214 Length:833 Species:Saccharomyces cerevisiae


Alignment Length:521 Identity:109/521 - (20%)
Similarity:194/521 - (37%) Gaps:140/521 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   170 DKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPL------HAAASNGQINVVKHLLNL 228
            |.:...|.|||..||:|.:...|...|..:...:.:|.|||      |.:.:......:..||: 
Yeast   392 DPELHTAFHWACSMGNLPIAEALYEAGTSIRSTNSQGQTPLMRSSLFHNSYTRRTFPRIFQLLH- 455

Human   229 GVEIDEINVYGNTALH----------IACYNGQDAVVNELIDYGAN------VNQPNNNGFTPLH 277
             ..:.:|:....|.:|          .|.|. .|.|::::.|:...      :|..:.||.|.||
Yeast   456 -ETVFDIDSQSQTVIHHIVKRKSTTPSAVYY-LDVVLSKIKDFSPQYRIELLLNTQDKNGDTALH 518

Human   278 FAAASTHG-ALCLELLVNNGADVNIQSKDGKSPLHMTA---VHGRFTRSQTLIQNGGEIDCVDKD 338
            .  ||.:| .:....||..||...|.:|:|     :||   ::.::  .|.:||||.....  ..
Yeast   519 I--ASKNGDVVFFNTLVKMGALTTISNKEG-----LTANEIMNQQY--EQMMIQNGTNQHV--NS 572

Human   339 GNTPLHVAARYGHELLINTLITSGADTAKCGIHSM-------------FPLHLAALNAHSDCCRK 390
            .||.|::     |   :|   |:..:| |..::||             :|..:|. |...:....
Yeast   573 SNTDLNI-----H---VN---TNNIET-KNDVNSMVIMSPVSPSDYITYPSQIAT-NISRNIPNV 624

Human   391 LLSSGQKYSIVSLFSNEHVLSAGFEIDTPDK----FGRTCLHAAAAGGNVECIKLLQSSGADFHK 451
            :.|..|..||.:....:|    ..||.:..|    ..:|.:..     :::.:::|:.|     .
Yeast   625 VNSMKQMASIYNDLHEQH----DNEIKSLQKTLKSISKTKIQV-----SLKTLEVLKES-----S 675

Human   452 KDKCGRTPLHYAAANCHFHCIETLVTTGAN------------VNETDDWGRTALHYAAASDMDR- 503
            ||:.|.     |..|..|..:..|......            :.:..::.:|.|......|..: 
Yeast   676 KDENGE-----AQTNDDFEILSRLQEQNTKKLRKRLIRYKRLIKQKLEYRQTVLLNKLIEDETQA 735

Human   504 --NKTILGNAHDNS--EELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQ 564
              |.|:   ..||:  |.||.|:||      ..|:...:|..:..::..|....||        :
Yeast   736 TTNNTV---EKDNNTLERLELAQEL------TMLQLQRKNKLSSLVKKFEDNAKIH--------K 783

Human   565 CLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKG 629
            ...::.|.|....||.||                 :|:|:||:|:..:.:::.....:.::....
Yeast   784 YRRIIREGTEMNIEEVDS-----------------SLDVILQTLIANNNKNKGAEQIITISNANS 831

Human   630 H 630
            |
Yeast   832 H 832

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANKRD44NP_001354424.1 ANK 1 7..36
ANK 2 40..69
ANK 3 73..102
ANK 4 106..135
ANK 5 139..168
ANK 6 172..201 9/28 (32%)
ANK 7 205..234 7/34 (21%)
ANK 8 238..267 7/44 (16%)
ANK 9 271..301 12/30 (40%)
ANK 10 305..334 8/31 (26%)
ANK 11 338..367 7/28 (25%)
ANK 13 422..451 3/28 (11%)
ANK 14 455..484 5/40 (13%)
ANK 15 488..516 7/32 (22%)
ANK 16 549..579 5/29 (17%)
ANK 17 584..613 5/28 (18%)
ANK 18 617..646 1/14 (7%)
ANK 19 651..680
ANK 20 687..716
ANK 21 720..749
ANK 22 753..782
ANK 23 789..818
ANK 24 821..850
ANK 25 856..885
ANK 26 889..919
ANK 27 923..952
ANK 28 959..988
MBP1NP_010227.1 KilA-N 22..93 CDD:367917
ANKYR 363..544 CDD:223738 39/156 (25%)
ANK repeat 396..425 CDD:293786 9/28 (32%)
ANK repeat 427..510 CDD:293786 16/85 (19%)
ANK repeat 512..543 CDD:293786 13/32 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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