DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANKRD44 and ankrd28

DIOPT Version :9

Sequence 1:	NP_001354424.1	Gene:	ANKRD44 / 91526	HGNCID:	25259	Length:	1074	Species:	Homo sapiens
Sequence 2:	XP_031760399.1	Gene:	ankrd28 / 734050	XenbaseID:	XB-GENE-5857499	Length:	1113	Species:	Xenopus tropicalis

Alignment Length:	1126	Identity:	735/1126 - (65%)
Similarity:	853/1126 - (75%)	Gaps:	110/1126 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    10 PPLVQAIFSGDPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMW 74
            ||||||||:|||:|:|.||.|.||||..|:|||||||.||:|||||||||||||||||||||:.|
Frog    37 PPLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 101

Human    75 LTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRG 139
            ||||||||||.||:|||||:||||||||||||||||||:|||||||||||.::||||:||||||.
Frog   102 LTPLHRAVASCSEDAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA 166

Human   140 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 204
            |||||||||.:||||||:|||::||||||||||||||:||||||||::||.||:.|||||.||||
Frog   167 GRTALHHAAFSGHVEMVSLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVTHGAEVMCKDK 231

Human   205 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 269
            |.|||||||||:|.|:|:|:||:|||:::|.|.||||.||:|||||||.|||||||.||||||.|
Frog   232 KSYTPLHAAASSGMISVIKYLLDLGVDMNESNAYGNTPLHVACYNGQDVVVNELIDCGANVNQVN 296

Human   270 NNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDC 334
            ..||||||||||||||||||||||.|||||||:|||||:||||||:||||:|||.:||||.||||
Frog   297 ERGFTPLHFAAASTHGALCLELLVCNGADVNIKSKDGKTPLHMTAIHGRFSRSQIIIQNGAEIDC 361

Human   335 VDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGQKYS 399
            .||:||||||:||||||||||||||||.|||:|.|||.|||||||||:..||||||||||
Frog   362 EDKNGNTPLHIAARYGHELLINTLITSRADTSKRGIHGMFPLHLAALSGFSDCCRKLLSS----- 421

Human   400 IVSLFSNEHVLSAGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 464
                         ||:|||.|.||||||||||||||:||:.||.|:||||:||||.|||||||||
Frog   422 -------------GFDIDTHDDFGRTCLHAAAAGGNLECLNLLLSTGADFNKKDKFGRTPLHYAA 473

Human   465 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEA 529
            |||::.|:..||.:||:||:.|:.|.:.|||||.||.|..
Frog   474 ANCNYQCLFALVGSGASVNDLDERGCSPLHYAATSDTDGK------------------------- 513

Human   530 TLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT-------NSG---FEESDSGA 584
              |||:||:|||||.||||.|||::|||||||||.||||:...|       .||   ..::::.|
Frog   514 --CLEYLLRNDANPGIRDKHGYNAVHYAAAYGHRLCLELIARETPLDVLMETSGTDMLNDAETRA 576

Human   585 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGASIFVKDN 649
            ..||||||||:|||||||||:|||:|||:|:..|||.|||||||||.|||:.||||||||.|||.
Frog   577 PISPLHLAAYHGHHQALEVLVQSLLDLDVRNSTGRTPLDLAAFKGHVECVDVLINQGASILVKDY 641

Human   650 VTKRTPLHA---------------------------------SVINGHTLCLRLLLEIADNPEAV 681
            |.||||:|:                                 |.||||:.|||||:..||...||
Frog   642 VVKRTPIHSAEIQMVDSRNSVNKNNTELCNSAQKKVRAKDMPSAINGHSECLRLLIGNADVQAAV 706

Human   682 DVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS 746
            |:.|..|||||||:|..||.:.|..||.|.||||..|..|.||||||.:|||||||:.||:...:
Frog   707 DIHDGNGQTPLMLSVLNGHTECVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVEALLQHNAN 771

Human   747 ILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC-CFKDNQGYTPLHWACYNGNENCIEVLL 810
            .|.:|.|||||:|.|||.||...||.|||.|:|.:.. ...||.||||||||||||::.|:|:||
Frog   772 FLLRDCRGRTPIHLAAACGHIGVLSALLQTAISVDVVPAIADNHGYTPLHWACYNGHDACVELLL 836

Human   811 EQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLHAAAFADHVECLQL 875
            ||:.|:|..||.|:|||||:|||:...|.:|:..:.:|||:..|.|||||||||||.||:|||||
Frog   837 EQEVFQKMEGNSFSPLHCAVINDNEGAAEMLIDTLGTSIVNSVDSKGRTPLHAAAFTDHIECLQL 901

Human   876 LLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCA 940
            ||.|:|.|||||::|||.|||||||||..||::||:||:||||::||:.||.||||||||||..|
Frog   902 LLSHNAQVNAVDSTGKTPLMMAAENGQTSAVEVLVSSAKADLTLQDKNKNTALHLACSKGHETSA 966

Human   941 LLILDKIQDESLINEKNNALQTPLHVAARNGLKVVVEELLAKGACVLAVDENGHTPALACAPNKD 1005
            ||||::|.|.:|||..|:||||||||||||||.|||:|||.|||.||||||||:|||||||||||
Frog   967 LLILEQITDRNLINATNSALQTPLHVAARNGLTVVVQELLGKGASVLAVDENGYTPALACAPNKD 1031

Human  1006 VADCLALILATMMPFS-----PSSTMMAVNFVCLKKDNLSRT-TLSNLGSM----VSLCS-NNVG 1059
            ||||||||||||||.|     ||.|:.|:|..    :|.|:| |...|..|    .|.|| ||:|
Frog  1032 VADCLALILATMMPVSSSSSLPSMTLNAINHY----NNTSKTVTFDTLPVMRSEHSSYCSFNNIG 1092

Human  1060 SEDGY------NENDSDSETF 1074
            .||||      ..|||||||:
Frog  1093 REDGYPYTEEDELNDSDSETY 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANKRD44	NP_001354424.1	ANK 1	7..36		19/25 (76%)
		ANK 2	40..69		26/28 (93%)
		ANK 3	73..102		24/28 (86%)
		ANK 4	106..135		23/28 (82%)
		ANK 5	139..168		22/28 (79%)
		ANK 6	172..201		22/28 (79%)
		ANK 7	205..234		19/28 (68%)
		ANK 8	238..267		24/28 (86%)
		ANK 9	271..301		27/29 (93%)
		ANK 10	305..334		22/28 (79%)
		ANK 11	338..367		25/28 (89%)
		ANK 13	422..451		23/28 (82%)
		ANK 14	455..484		18/28 (64%)
		ANK 15	488..516		9/27 (33%)
		ANK 16	549..579		19/39 (49%)
		ANK 17	584..613		23/28 (82%)
		ANK 18	617..646		23/28 (82%)
		ANK 19	651..680		17/61 (28%)
		ANK 20	687..716		17/28 (61%)
		ANK 21	720..749		16/28 (57%)
		ANK 22	753..782		18/28 (64%)
		ANK 23	789..818		19/28 (68%)
		ANK 24	821..850		13/28 (46%)
		ANK 25	856..885		23/28 (82%)
		ANK 26	889..919		21/29 (72%)
		ANK 27	923..952		19/28 (68%)
		ANK 28	959..988		24/28 (86%)
ankrd28	XP_031760399.1	ANK repeat	38..65	CDD:293786	19/26 (73%)
		PHA03095	49..>337	CDD:222980	232/287 (81%)
		ANK repeat	67..98	CDD:293786	28/30 (93%)
		ANK repeat	103..131	CDD:293786	24/27 (89%)
		ANK repeat	133..164	CDD:293786	25/30 (83%)
		ANK repeat	167..197	CDD:293786	24/29 (83%)
		ANK repeat	199..230	CDD:293786	23/30 (77%)
		ANK repeat	232..263	CDD:293786	20/30 (67%)
		PHA03095	246..>532	CDD:222980	218/330 (66%)
		ANK repeat	265..296	CDD:293786	26/30 (87%)
		ANK repeat	298..329	CDD:293786	28/30 (93%)
		ANK repeat	332..363	CDD:293786	24/30 (80%)
		ANK repeat	365..395	CDD:293786	25/29 (86%)
		ANK repeat	402..429	CDD:293786	22/44 (50%)
		Ank_2	416..>651	CDD:423045	158/279 (57%)
		ANK repeat	431..462	CDD:293786	24/30 (80%)
		ANK repeat	464..495	CDD:293786	19/30 (63%)
		ANK repeat	497..529	CDD:293786	20/58 (34%)
		ANK repeat	531..561	CDD:293786	17/29 (59%)
		ANK repeat	563..607	CDD:293786	26/43 (60%)
		ANK repeat	609..640	CDD:293786	24/30 (80%)
		PHA03095	694..>1023	CDD:222980	209/328 (64%)
		ANK repeat	712..743	CDD:293786	18/30 (60%)
		ANK repeat	745..776	CDD:293786	17/30 (57%)
		ANK repeat	882..913	CDD:293786	25/30 (83%)
		ANK repeat	915..947	CDD:293786	22/31 (71%)
		ANK repeat	949..1016	CDD:293786	49/66 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54384
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1776
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930