DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANKRD44 and Ank2

DIOPT Version :9

Sequence 1:	NP_001354424.1	Gene:	ANKRD44 / 91526	HGNCID:	25259	Length:	1074	Species:	Homo sapiens
Sequence 2:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster

Alignment Length:	940	Identity:	274/940 - (29%)
Similarity:	413/940 - (43%)	Gaps:	130/940 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    76 TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG 140
            |...||..:.:.|.|...:|::.|:|..:.|....||:|:.:..:.....::...:.|:.:.:.|
  Fly    13 TSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKG 77

Human   141 RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 205
            .||||.|:|.|..|:|.|||...|::|...:.....|:.||...|..||.||:::||..:...:.
  Fly    78 NTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATED 142

Human   206 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNN 270
            |:|||..|...|...||..||    |.|........|||||...........|:|...|.:..:.
  Fly   143 GFTPLAVAMQQGHDKVVAVLL----ESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSK 203

Human   271 NGFTPLHFAAASTHGALCL-ELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDC 334
            :||||||.  ||.:|...: .||:..|||||..:|...||||:.|..|:......|::.||.|:.
  Fly   204 SGFTPLHI--ASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEA 266

Human   335 VDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGQKYS 399
            ..:||.||||.|||.|||.:::.|:..||..:....:.:.|||:||...|.|..|.||..
  Fly   267 KTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYH----- 326

Human   400 IVSLFSNEHVLSAGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 464
                       .|..:..|.|..  |.||.||..|:|...|||....||.:.:...|.||||.|.
  Fly   327 -----------RAPVDEVTVDYL--TALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIAC 378

Human   465 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEA 529
            .......:|.|:..||:::.|.:.|.|.||.||         .:|
  Fly   379 KKNRLKVVELLLRHGASISATTESGLTPLHVAA---------FMG-------------------- 414

Human   530 TLCLE---FLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHL 591
              |:.   :|||:||:|.:....|                                   ::||||
  Fly   415 --CMNIVIYLLQHDASPDVPTVRG-----------------------------------ETPLHL 442

Human   592 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGASIFVKDNVTK--RT 654
            ||.......:.:||::...:|.|..:.:|.|.:|:..|:.:.|..|:..||.:   |..||  .|
  Fly   443 AARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQV---DATTKDMYT 504

Human   655 PLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDI 719
            .||.:...|......:|:|   |..|:|....||.|||.|...||||....|||:|||:||....
  Fly   505 ALHIAAKEGQDEVAAVLIE---NGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGK 566

Human   720 LGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGH---ATWLSELLQMALSEE 781
            .|.|.||......:::...:|||:..|.......|.||||.||.:..   ||.|.|...:|.:|
  Fly   567 NGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAE- 630

Human   782 DCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP----FTPLHCAIINDHGNCASLLL 842
                 ...|:||||.:...|:.....:|:|.|.   .:.:|    .||:|.....|:.|.|.:|
  Fly   631 -----SKAGFTPLHLSSQEGHAEISNLLIEHKA---AVNHPAKNGLTPMHLCAQEDNVNVAEIL- 686

Human   843 GAIDSSIVSCRDDKGRTPLHAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVD 907
             ..:.:.:......|.||||.|:.......::.||::.|.|:|..:.|.|.|...|:.|....|:
  Fly   687 -EKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVN 750

Human   908 ILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNALQTPLHVAARNGL 972
            :|:.. :|:...:..:..||||:|...|:    :.:||.::   .|.:::.....|..  |....
  Fly   751 LLLEH-KANANAQTVNGQTPLHIARKLGY----ISVLDSLK---TITKEDETAAAPSQ--AEEKY 805

Human   973 KVVVEELLAKGACVLAVDENGHTPALACAP 1002
            :||..|.:.:.....:.:|.|....|:..|
  Fly   806 RVVAPEAMHESFMSDSEEEGGEDNMLSDQP 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANKRD44	NP_001354424.1	ANK 1	7..36
		ANK 2	40..69
		ANK 3	73..102		7/25 (28%)
		ANK 4	106..135		5/28 (18%)
		ANK 5	139..168		14/28 (50%)
		ANK 6	172..201		10/28 (36%)
		ANK 7	205..234		11/28 (39%)
		ANK 8	238..267		8/28 (29%)
		ANK 9	271..301		15/30 (50%)
		ANK 10	305..334		10/28 (36%)
		ANK 11	338..367		15/28 (54%)
		ANK 13	422..451		12/28 (43%)
		ANK 14	455..484		10/28 (36%)
		ANK 15	488..516		7/27 (26%)
		ANK 16	549..579		1/29 (3%)
		ANK 17	584..613		8/28 (29%)
		ANK 18	617..646		8/28 (29%)
		ANK 19	651..680		9/30 (30%)
		ANK 20	687..716		17/28 (61%)
		ANK 21	720..749		8/28 (29%)
		ANK 22	753..782		13/31 (42%)
		ANK 23	789..818		9/28 (32%)
		ANK 24	821..850		8/32 (25%)
		ANK 25	856..885		10/28 (36%)
		ANK 26	889..919		8/29 (28%)
		ANK 27	923..952		8/28 (29%)
		ANK 28	959..988		5/28 (18%)
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786	8/27 (30%)
		Ank_4	11..64	CDD:290365	12/50 (24%)
		ANK	38..163	CDD:238125	39/124 (31%)
		ANK repeat	43..74	CDD:293786	5/30 (17%)
		Ank_2	48..135	CDD:289560	28/86 (33%)
		ANK repeat	76..107	CDD:293786	15/30 (50%)
		ANK repeat	109..134	CDD:293786	8/24 (33%)
		Ank_4	110..163	CDD:290365	18/52 (35%)
		Ank_4	172..225	CDD:290365	18/54 (33%)
		ANK repeat	175..202	CDD:293786	8/26 (31%)
		ANK	199..324	CDD:238125	50/126 (40%)
		ANK repeat	204..235	CDD:293786	16/32 (50%)
		Ank_2	209..300	CDD:289560	38/92 (41%)
		ANK repeat	237..268	CDD:293786	10/30 (33%)
		ANK	266..390	CDD:238125	47/141 (33%)
		ANK repeat	270..300	CDD:293786	15/29 (52%)
		ANK repeat	303..367	CDD:293786	25/81 (31%)
		Ank_2	308..399	CDD:289560	34/108 (31%)
		ANK	364..489	CDD:238125	41/190 (22%)
		ANK repeat	369..400	CDD:293786	10/30 (33%)
		ANK repeat	402..433	CDD:293786	14/61 (23%)
		Ank_4	403..456	CDD:290365	21/118 (18%)
		ANK repeat	435..466	CDD:293786	10/65 (15%)
		Ank_2	440..530	CDD:289560	28/95 (29%)
		ANK	463..588	CDD:238125	44/130 (34%)
		ANK repeat	468..497	CDD:293786	8/31 (26%)
		ANK repeat	501..530	CDD:293786	8/31 (26%)
		Ank_2	506..597	CDD:289560	34/93 (37%)
		ANK	529..654	CDD:238125	46/130 (35%)
		ANK repeat	535..565	CDD:293786	17/29 (59%)
		ANK repeat	567..598	CDD:293786	8/30 (27%)
		Ank_2	572..661	CDD:289560	28/97 (29%)
		ANK repeat	600..630	CDD:293786	12/29 (41%)
		ANK repeat	633..662	CDD:293786	9/31 (29%)
		ANK	661..785	CDD:238125	35/130 (27%)
		ANK repeat	666..697	CDD:293786	7/32 (22%)
		Ank_2	672..762	CDD:289560	24/92 (26%)
		ANK repeat	699..730	CDD:293786	11/30 (37%)
		ANK repeat	732..762	CDD:293786	8/30 (27%)
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53364at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720