DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANKRD44 and trp-4

DIOPT Version :9

Sequence 1:	NP_001354424.1	Gene:	ANKRD44 / 91526	HGNCID:	25259	Length:	1074	Species:	Homo sapiens
Sequence 2:	NP_493429.2	Gene:	trp-4 / 190574	WormBaseID:	WBGene00006616	Length:	1924	Species:	Caenorhabditis elegans

Alignment Length:	1108	Identity:	316/1108 - (28%)
Similarity:	482/1108 - (43%)	Gaps:	178/1108 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    20 DPEEIRMLIHKTEDVNTLDSE----KRTPLHVA------AFL-----GDAEIIELLILSGARV-- 67
            ||:...:...|.::...::||    ||:...:|      |||     |..:|::.:|..||||
Worm   317 DPQTKILYFAKRDEWANVESEIETIKRSDFSMADNHGFTAFLLAVKAGKDQIVDKMIRKGARVDY 381

Human    68 NAKDNMWLTPLHRAVASRSEEAVQVLIKHSADV---NARDKNWQTPLHVAAANKAVKCAEVIIPL 129
            :.||....|  |.|......|.:::::|..:::   .|..|. |..:|||...|:.|...::..:
Worm   382 STKDGRNAT--HIAAMYSGVETLELILKRYSELLRKGAGPKK-QLAIHVACERKSKKAFPIVKRI 443

Human   130 LSSVN---VSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRA-------LHWAAYMG 184
            |...:   ..|..|...:|.|...|:|.:|.|||:     ...|::.|:|       ||.||..|
Worm   444 LEDTDQRMAEDGDGSLPIHLAFKFGNVNIVELLLS-----GPSDEQTRKADGNGDTLLHLAARSG 503

Human   185 HLDVVALLINHGAE-VTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACY 248
            :::.|...|..|.: ...:::.|.||||..|..|..|::|.:..|..:.:..:....|.:|:|..
Worm   504 NIEAVRTAIAAGCDNANVQNRVGRTPLHEVAEVGDQNMLKIMFKLRADANIHDKEDKTPVHVAAE 568

Human   249 NGQDAVVNELID-YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHM 312
            .|..::|..||| :|.::.....:|.|.||.||.|.|.:..|..| ..|..:.:.:|.|...||.
Worm   569 RGDTSMVESLIDKFGGSIRARTRDGSTLLHIAACSGHTSTALAFL-KRGVPLFMPNKKGALGLHS 632

Human   313 TAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGADT-AKCGIHSMFPL 376
            .|..|.....:.||..|..:|...:|..|.||||.:.|...::.||:.||||. .|.|......|
Worm   633 AAAAGFNDVVKMLIARGTNVDVRTRDNYTALHVAVQSGKASVVETLLGSGADIHVKGGELGQTAL 697

Human   377 HLAA-LN-AHS-DCCRKLLSSGQKYSIVSLFSNEHVLSAGFEIDTPDKFGRTCLHAAAAGGNVEC 438
            |:|| || |.| ||...||.||.:..:.             ::|     |.||||.||..||.:.
Worm   698 HIAASLNGAESRDCAMMLLKSGGQPDVA-------------QMD-----GETCLHIAARSGNKDI 744

Human   439 IKLLQSSGADFHKKDKCGRTPLHYAAANCHF--------HCIETLV--TTGANVNETDDWGRTAL 493
            ::||....||.....|.|.|||..||.:|:|        |..|.|.  ....:||...:.|.|||
Worm   745 MRLLLDENADSKISSKIGETPLQVAAKSCNFEAASMILKHLSEVLTQEQLKEHVNHRTNDGFTAL 809

Human   494 HYAAASDMDRNKTILGNAHDNSEELERAREL-----KEKEATLCLEF--LLQNDANPSIRDKEGY 551
            ||||                   |:|: |:|     ..|...|.:::  :::   .||:...|
Worm   810 HYAA-------------------EIEQ-RQLHFPGEDAKLVNLLIDYGGMVE---MPSLNANE-- 849

Human   552 NSIHYAAAYGHRQCLELLLERTNSGF------EESDSGATKSPLHLAAYNGHHQALEVLLQSLVD 610
            .::|.||..|::..|..::.:..:|.      ::|.:|  .|||..|...||.....:||:....
Worm   850 TAMHMAARSGNQAVLLAMVNKIGAGAVQIVQNKQSKNG--WSPLLEACARGHSGVANILLKHHAR 912

Human   611 LDIRDEKGRTALDLAAFKGHTECVEALINQGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE-- 673
            :|:.||.|||||.||||.||...|..|:...|.:..|.. |...|||.:..:||...:.:|::
Worm   913 IDVFDEMGRTALHLAAFNGHLSLVHLLLQHKAFVNSKSK-TGEAPLHLAAQHGHVKVVNVLVQDH 976

Human   674 -------IADNPEAV----------------------DVKDAKGQTPLMLAVAYGHIDAVSLLLE 709
                   ..||..|:                      :.:|.||||||.||......|.|.|.|:
Worm   977 GAALEAITLDNQTALHFAAKFGQLAVSQTLLALGANPNARDDKGQTPLHLAAENDFPDVVKLFLK 1041

Human   710 KEAN----VDTVDILGCTALHRGIMTGHEECVQ--MLLEQEVSILCK-DSRGRTPLHYAAARGHA 767
            ...|    :..:|..|.|..|...|.|....|:  |::::.:.|..| .:...|.||.|||.|||
Worm  1042 MRNNNRSVLTAIDHNGFTCAHIAAMKGSLAVVRELMMIDKPMVIQAKTKTLEATTLHMAAAGGHA 1106

Human   768 TWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEV---LLEQKCFRKFIGNPFTPLHCA 829
            ..:..||:...:.||   :::.|.|.||....||..:.:|.   :|.::|.||   .....||.|
Worm  1107 NIVKILLENGANAED---ENSHGMTALHLGAKNGFISILEAFDKILWKRCSRK---TGLNALHIA 1165

Human   830 IINDHGNCASLLLGAIDSSIVS------------CRDDKGRTPLHAAAFADHVECLQLLLRHSAP 882
            ....:.:..:.:|..:.:::.|            ...:.|.||||.||.:.|...:::||.....
Worm  1166 AFYGNSDFVNEMLKHVQATVRSEPPIYNHHVNKEFSTEYGFTPLHLAAQSGHDSLVRMLLNQGVQ 1230

Human   883 VNAVDNS-GKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 946
            |:|...: ....|.:||:.|....|.:|::.:......||....||||||...||.:...|:
Worm  1231 VDATSTTMNVIPLHLAAQQGHIAVVGMLLSRSTQQQHAKDWRGRTPLHLAAQNGHYEMVSLL--- 1292

Human   947 IQDESLINEKNNALQTPLHVAARNGLKVVVEELLAKGACVLAVDENGHTPALACAPNKDVADCLA 1011
            |...|.||..:....|.||.|.|.|...||:..:...|..||..:.|..|....|.:..: :||.
Worm  1293 IAQGSNINVMDQNGWTGLHFATRAGHLSVVKLFIDSSADPLAETKEGKVPLCFAAAHNHI-ECLR 1356

Human  1012 LIL 1014
            .:|
Worm  1357 FLL 1359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANKRD44	NP_001354424.1	ANK 1	7..36		3/15 (20%)
		ANK 2	40..69		14/45 (31%)
		ANK 3	73..102		5/31 (16%)
		ANK 4	106..135		7/31 (23%)
		ANK 5	139..168		9/28 (32%)
		ANK 6	172..201		10/36 (28%)
		ANK 7	205..234		10/28 (36%)
		ANK 8	238..267		9/29 (31%)
		ANK 9	271..301		11/29 (38%)
		ANK 10	305..334		8/28 (29%)
		ANK 11	338..367		13/29 (45%)
		ANK 13	422..451		13/28 (46%)
		ANK 14	455..484		12/38 (32%)
		ANK 15	488..516		8/27 (30%)
		ANK 16	549..579		7/35 (20%)
		ANK 17	584..613		8/28 (29%)
		ANK 18	617..646		14/28 (50%)
		ANK 19	651..680		9/37 (24%)
		ANK 20	687..716		13/32 (41%)
		ANK 21	720..749		8/30 (27%)
		ANK 22	753..782		11/28 (39%)
		ANK 23	789..818		10/31 (32%)
		ANK 24	821..850		4/28 (14%)
		ANK 25	856..885		11/28 (39%)
		ANK 26	889..919		6/30 (20%)
		ANK 27	923..952		10/28 (36%)
		ANK 28	959..988		9/28 (32%)
trp-4	NP_493429.2	ANK repeat	804..842	CDD:293786	14/60 (23%)
		ANK repeat	849..884	CDD:293786	7/36 (19%)
		ANK repeat	886..917	CDD:293786	10/32 (31%)
		ANK repeat	919..950	CDD:293786	14/30 (47%)
		ANK repeat	952..982	CDD:293786	7/29 (24%)
		ANK repeat	986..1017	CDD:293786	3/30 (10%)
		PHA03095	1006..>1336	CDD:222980	97/338 (29%)
		ANK repeat	1092..1123	CDD:293786	13/33 (39%)
		ANK repeat	1204..1236	CDD:293786	12/31 (39%)
		trp	1209..1879	CDD:273311	47/155 (30%)
		ANK repeat	1238..1270	CDD:293786	6/31 (19%)
		ANK repeat	1272..1303	CDD:293786	13/33 (39%)
		ANK repeat	1305..1336	CDD:293786	11/30 (37%)
		ANK repeat	1338..1366	CDD:293786	6/23 (26%)
		ANKYR	280..515	CDD:223738	54/205 (26%)
		ANK repeat	352..383	CDD:293786	10/30 (33%)
		ANK repeat	385..418	CDD:293786	6/34 (18%)
		ANK repeat	424..454	CDD:293786	6/29 (21%)
		PHA03095	430..>756	CDD:222980	107/349 (31%)
		ANK repeat	456..489	CDD:293786	11/37 (30%)
		ANK repeat	491..523	CDD:293786	8/31 (26%)
		ANK repeat	526..556	CDD:293786	10/29 (34%)
		ANK repeat	558..590	CDD:293786	9/31 (29%)
		ANK repeat	592..623	CDD:293786	11/31 (35%)
		ANK repeat	625..656	CDD:293786	9/30 (30%)
		ANK repeat	658..688	CDD:293786	13/29 (45%)
		ANK repeat	692..726	CDD:293786	14/46 (30%)
		PHA02876	<712..>1040	CDD:165207	105/373 (28%)
		ANK repeat	728..753	CDD:293786	12/29 (41%)
		ANK repeat	761..802	CDD:293786	13/40 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	310	1.000	Inparanoid score	I1775
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.870