Protein Alignment SLC6A5 and DAT

DIOPT Version :9

• Sequence 1: NP_004202.4
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Alignment Length: 601
• Identity: 275/601 - (45%)
• Similarity: 388/601 - (64%)
• Gaps: 21/601 - (3%)

Human   172 GSVATVATQEDEQGDENK---ARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPY 233
            |.::...|......|.|.   .|..||.|:||:||::|:||.|.||||||||.::|||||||:||
  Fly     5 GHISKSKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPY 69

Human   234 LMMLALAGLPIFFLEVSLGQFASQGPVSVW-KAIPALQGCGIAMLIISVLIAIYYNVIICYTLFY 297
            .:||.:.|:|:|::|::|||...:|.::.| :.:|..:|.|.|:::|:..:..||||||.::|.:
  Fly    70 GIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRF 134

Human   298 LFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCM---TAYPNVTMVNF 359
            .||||.:.|||.||||.||||.|:.     .:|...|..|.|...:..:.|   :...|.|.:|.
  Fly   135 FFASFTNSLPWTSCNNIWNTPNCRP-----FESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNG 194

Human   360 TSQANKT------FVSGSEEYFKYFVLKI--SAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIK 416
            :|.....      |.|.:.|||..::|::  |.||...|.|:|.:||||.:.::|.|.||.|||.
  Fly   195 SSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGIS 259

Human   417 TSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAA 481
            ||||||:|||.|||.||:||||||:||||:..||.|::||.:..:..|.||.|||||:||||...
  Fly   260 TSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPG 324

Human   482 WGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIA 546
            :|.|:..:||||:|||.|:|.|:.:..|||||..||||||||:|:||:...|.||:||.:|||:.
  Fly   325 FGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLV 389

Human   547 FVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCI 611
            |||||.|:..:|.|.|||:|||:||||||||:.|...|.|:|::|||||| ::.::.:|..|...
  Fly   390 FVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPK-IKRNRELFVAGLFS 453

Human   612 CFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIF 676
            .:|::|....||||.|.|.|:|.|||.|::::...||.:.:|::||..||.|||..||||.|..:
  Fly   454 LYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRY 518

Human   677 WKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAP 741
            |:|||.||.|..|.||..:....:||:||..|.||:|:..|||.:...||:.||.:.:.|:...|
  Fly   519 WQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTP 583

Human   742 GRFIERLKLVCSPQPD 757
            |...:|..::.:|..|
  Fly   584 GSLRQRFTILTTPWRD 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118
		SLC6sbd_GlyT2	191..787	CDD:271389	271/579 (47%)
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	269/575 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820