Protein Alignment SLC6A5 and CG13794

DIOPT Version :10

• Sequence 1: NP_004202.4
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_609137.2
• Gene: CG13794 / 34048
• FlyBaseID: FBgn0031936
• Length: 595
• Species: Drosophila melanogaster
• Alignment Length: 607
• Identity: 160/607 - (26%)
• Similarity: 270/607 - (44%)
• Gaps: 68/607 - (11%)

Human   191 RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFA 255
            ||.|....|:|.:..|.|:.| :::...|..|.:.|...::|||:.:.:..:||..:...:|||:
  Fly    20 RGKWDKPTDYIFACFGLALKL-DIFVASYWFFFDMGIFGMLPYLVYMVIYLVPIMVIHSFMGQFS 83

Human   256 SQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCN--NPW-NT 317
            |.|.:|.::..|..:|.|...:.:::.:.|||::.....|.::..||...||| ||.  ..| |.
  Fly    84 SSGFISAFRLSPFFKGMGYVSVFLTISMLIYYSIFAAVPLLFMINSFRPTLPW-SCEGFKSWYNE 147

Human   318 PECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKI 382
            .:.|..|..:..|..::|:..   .|:.|....:...:::.|.    |.|.|..||.:
  Fly   148 SDGKMTTCNMTISEDLTDNSD---NNTDFHRPHFHVPSVLYFL----KHFESVQEENY------- 198

Human   383 SAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTS--GKVVYFTATFPYVVLVILLIRGVTLPG 445
             :.:....::.|.......|.|.:|.....|..:|:  ||.:.:......::|::...|.:.|||
  Fly   199 -SDLRQDYDLSWRFVSLFVLVWAMVAFIFYKFSETAMFGKFIRYMVIGTLILLLVCFGRFLFLPG 262

Human   446 AGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNS 510
            |..|:..::||..:::  |.........:..:..|.||.:|.|||:|.|..:....:.|:    |
  Fly   263 ALLGLRKYVTPSPDEI--AMGIGSTFVMVLHAFGAGWGSVIALSSFNGFKTDIMSYSWII----S 321

Human   511 ATSIFAGFVIFSVIGFMA----NERKVNIENVADQGPGIAFVVY---PEALTRLPLSPFWAIIFF 568
            ...||. |.:|.::.:|.    ||   .||...|:.....:.:|   ..||:.|.....|..|::
  Fly   322 FGQIFI-FTMFGLVSYMLDHYYNE---GIEGSFDKQVLTHWALYLSSATALSSLGWPNLWTFIYY 382

Human   569 LMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVD 633
            .|||...|..:...|.|::.|:.||| :.||..|...|.|......:..|...|..||..|.
  Fly   383 TMLLMAALIVITTQIFTVLQSLFDEF-EVLRVRKQEVTFGLIGGIAVCSFYFCTNHGITFFS--- 443

Human   634 TYAASYALVIIAIFE--------LVGISYVYGLQRFCEDIEMMIGFQPNIFWKV-CWAFVTPTIL 689
                  ||.:.|||.        |:.:.::||.:||..|||.|:| ||...||| ...|:.|.||
  Fly   444 ------ALALDAIFSHSLLHLLLLLVVLWIYGRERFQRDIEFMLG-QPFASWKVYILRFIAPIIL 501

Human   690 TFILCFSFYQWEPMTYGSYRYPNWSMVLGW--LMLACSVIWIPIMFVIKMHLAPGRFIERLKLVC 752
            ...|.....    :.|..:.|.: ::|||.  :::...::.||...:..::.:.|.|.||.|..|
  Fly   502 IICLVVGIL----VCYMEHIYSS-AIVLGMSIILVILPILAIPGYGIYYIYRSTGSFCERFKRTC 561

Human   753 SPQPDWGPFLAQHRGERYKNMI 774
            .| .||.|...:|| ::|:..:
  Fly   562 RP-TDWYPVEMEHR-QQYEEAV 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118
		SLC6sbd_GlyT2	191..787	CDD:271389	160/607 (26%)
CG13794	NP_609137.2	SLC5-6-like_sbd	27..509	CDD:271356	137/519 (26%)