DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC6A5 and ine

DIOPT Version :9

Sequence 1:	NP_004202.4	Gene:	SLC6A5 / 9152	HGNCID:	11051	Length:	797	Species:	Homo sapiens
Sequence 2:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster

Alignment Length:	865	Identity:	284/865 - (32%)
Similarity:	434/865 - (50%)	Gaps:	151/865 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    14 ANSPEAAAAQG---------HPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQTFQSADARA 69
            ||.|.||.:..         :.:|...|        .||:.|.|..:|..:.|.|       ...
  Fly   129 ANQPTAAVSTSTVTFTIDDCNEEGDAIP--------AAASVPAPVTMPAISPTPA-------TLT 178

Human    70 CEAERPGVGSCKLSSP-------RAQAASAALRDL--------------------REAQGAQASP 107
            |.......|.....||       |..:..:::|.:                    ....|.||..
  Fly   179 CTTTTTMAGDSVAVSPLSMELKSRLGSHHSSMRSVVSGYLPGLSDSSGNLVGGVSMATSGLQAPN 243

Human   108 P---------PGSSG-----PGNALHCKIPFLRGPEGDANVSVG-----KGTLERNNTPVVGWVN 153
            |         .|||.     .||.::..:..:|..   |::.:|     |..:.|..|......:
  Fly   244 PLYMQPQASLSGSSYHFHELAGNQIYSDVTSVRSL---ASIGIGSTDGRKLVIRRVPTTANELFD 305

Human   154 M--SQSTVVLATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWR 216
            |  .|:...|..|...|.|..|        ||.......:.:|::|:.|:|:.:||:||||||||
  Fly   306 MVNPQTPPPLGVDDDDSYLDMS--------DETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWR 362

Human   217 FPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPV-SVWKAIPALQGCGIAMLIIS 280
            |||:.:::|||.||:||.::|.:..:|:.|:|:|:||:..:||: ::.:..|..:|.|:|.:::|
  Fly   363 FPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVS 427

Human   281 VLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNST 345
            .|::.||:|||.|:::|.|.||.:.:||..|||.||||:|
  Fly   428 FLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDC------------------------- 467

Human   346 FCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYAS 410
                ..|....:|  :.|..|..:.|||:|:..||:||.|:||||.:||.|..||..||::||.:
  Fly   468 ----WVPQRKGIN--ASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFA 526

Human   411 LAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIF 475
            ..|.||:|.||.|||||||:|:::||::|.|||.||..|:.:|..|||.:|.:|.||.:||:|.|
  Fly   527 TWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNF 591

Human   476 FSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD 540
            .||...:|.:|:.:||||::||..|||:.|:..|..||:..|...||.:|.:|.|:..|:.:|..
  Fly   592 NSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIG 656

Human   541 QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTH---K 602
            .|||:.|||||:|:.::|.:..||::||.|||.|||::.||.:|.:||||.|.||::::.|   .
  Fly   657 DGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYH 721

Human   603 PVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEM 667
            .:..|..|:...:.|.|.|.|||||.|||:|.||||..::.:|..:::.|::.||..|..::::.
  Fly   722 EIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQ 786

Human   668 MIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTY--GSYRYPNWSMVLGWLMLACSVIWIP 730
            |.|..|:.:.:.||..:.|.:|..|...|...:...||  |.|.||:|:..:||:..:.|:|.||
  Fly   787 MTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIP 851

Human   731 IMFVIKMHLAPG-RFIERLKLVCSPQ----------------PDWGPF-LAQHRGERYKNMIDPL 777
            ...||....:.| .|.||::....|.                |:...| |||.....||.....|
  Fly   852 GYAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHHCEHDYPEQEQFMLAQEMATVYKPTNPHL 916

Human   778 GTSSLGLKLPVKDLELGTQC 797
                         |.||.:|
  Fly   917 -------------LNLGQKC 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..118		29/153 (19%)
SLC6A5	NP_004202.4	SLC6sbd_GlyT2	191..787	CDD:271389	236/619 (38%)
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	227/569 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820