Protein Alignment SLC6A5 and NAAT1

DIOPT Version :10

• Sequence 1: NP_004202.4
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_572219.1
• Gene: NAAT1 / 31457
• FlyBaseID: FBgn0029762
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 638
• Identity: 241/638 - (37%)
• Similarity: 363/638 - (56%)
• Gaps: 55/638 - (8%)

Human   172 GSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMM 236
            |:....:|::.:.......|.||.:.|:|::|.:..:||||||||||:.|::||||||||||:::
  Fly    19 GATNAASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIV 83

Human   237 LALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFAS 301
            |.|.|.|:::||:.:|||.|||.|.:|..:|...|.|......::.|..||:.::..||:|||.|
  Fly    84 LFLIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFGTICIISYYSSLLALTLYYLFVS 148

Human   302 FVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQ---- 362
            |.|.|||..|.:.|.             :|| :..|:..:.|      ....|::.|.:::
  Fly   149 FQSELPWSYCRDEWT-------------NCV-NSRPQEYVDN------LLTGVSLANESARNLSG 193

Human   363 --AN---KTFVSGSEEYFKYFVLK----ISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTS 418
              ||   :...|.||.||...|:|    ||.|:   |:..|.|.|.||:|||:::..:.:|:|:|
  Fly   194 IVANDETEKLQSSSELYFLNVVIKEKLDISDGV---GDPDWKLTLALFVAWVVIFLVIMRGVKSS 255

Human   419 GKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWG 483
            ||..||.|.||||||.:||||.|||.||..||.:|:.|:|.:|.:.||||:|..|.||||:...|
  Fly   256 GKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGSG 320

Human   484 GLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKV-NIENVADQGPGIAF 547
            .:|..:|||:|.:..|||.:|||..::.||:..|..||:::|.:|:..:: ||.:|...|.|:||
  Fly   321 PIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAF 385

Human   548 VVYPEALTRLPLSP-FWAIIFFLMLLTLGLDTMFATIETIVTSISDEFP--KYLRTHKPVFTLGC 609
            :.||:|:::....| .::::||.||..||:.::.|...||||.|.|:|.  ||.:.     .|..
  Fly   386 ISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQFKGWKYWKV-----ALTT 445

Human   610 CICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPN 674
            .:|.|:||...:|.||.::..|||.|..:|.:.|:|||||.||.:|||||.||:|||.|...:.:
  Fly   446 SVCGFLMGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVWVYGLQNFCDDIEFMCNRRVS 510

Human   675 IFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPI--MFVIKM 737
            ::|:|||:|.||.::..|..:|....||:.|....:|..:.:.|||:.|......|:  ::.|..
  Fly   511 LYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELYFPEAANIAGWLLFAIGAAQFPLWGLWYISR 575

Human   738 HLAPGRFIERLKLVCSPQPDWGPFLAQHRGE--RYKNM-----IDPLGTSSLG 783
            | ..|.:.:.||....|...|||...:.|.|  .:||.     .....||.||
  Fly   576 H-PQGTYWKSLKASLKPSDRWGPANPEIRREWVIFKNQKAAQRATQKDTSKLG 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118
		SLC6sbd_GlyT2	191..787	CDD:271389	239/619 (39%)
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	211/520 (41%)