Protein Alignment SLC6A5 and CG33296

DIOPT Version :9

• Sequence 1: NP_004202.4
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_001285711.1
• Gene: CG33296 / 2768941
• FlyBaseID: FBgn0053296
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 623
• Identity: 164/623 - (26%)
• Similarity: 274/623 - (43%)
• Gaps: 101/623 - (16%)

Human   191 RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFA 255
            ||.|....|::.:..|.|:.| :::...|..|.|.|...::||.:.:.:..:||..:...:|||:
  Fly    20 RGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQFS 83

Human   256 SQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCN--NPWNTP 318
            |.|.::.::..|..:|.|...:.::....|||::.:...|.:|..||...||| ||.  ..|:
  Fly    84 SSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWH-- 145

Human   319 ECKDKTKLLLDSCVISDHPKI--QIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYF---KYF 378
               ::|......|    ||.|  |.:|.|..:.| |:....::..|          :||   |.|
  Fly   146 ---NRTDEYPTLC----HPTIYKQHENYTLGVEA-PSRLYFDYIRQ----------DYFNTDKRF 192

Human   379 VLKISAGIEYPGEIRWPLALCLFLAWVIV------YASLAKGIKTSGKVVYFTATFPYVVLVILL 437
                        :|..||.....|:|.::      ::..||    .||.:.:......|::|:..
  Fly   193 ------------DISRPLIGLFTLSWALIAIIFYHFSEPAK----FGKCIRYMVITTMVLVVVCF 241

Human   438 IRGVTLPGAGAGIWYFITPKWEKLTDATVWKD--AATQIFFSLSAAWGGLITLSSYNKFHNNCYR 500
            :|.:.|||:...:|.:|||..:..::. ::..  .|.|.|   .|.||.:|.|||:|.|..:...
  Fly   242 VRFLFLPGSHKLLWMYITPNTKDFSEG-IYSTFIMALQAF---GAGWGSVIALSSFNGFKTDIMS 302

Human   501 DTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD-------QGPGIAFVVYPEALTRLP 558
            .:.|:    |...||. :::|.::.||..:   ..::::|       ....:.|:....||..|.
  Fly   303 YSWII----SFGQIFI-YIMFGLVSFMLEQ---YYKDISDTIVFHRIMNFWVLFLSSASALNTLG 359

Human   559 LSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQ 623
            ....|..|::.|||...|..:...:.|::.|:.|||.| |:..|...|.|......|..|...|:
  Fly   360 WPNLWTFIYYSMLLLASLTVIATQLFTVLQSLFDEFEK-LKERKQEVTFGIICGLAICSFFFCTE 423

Human   624 GGIYMFQL--VDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTP 686
            .|.:.|.:  :|...|...|.::.   |:.:.::||.:||..|||.|:| ||...|||.....|.
  Fly   424 HGSFYFAILGIDVILAHSLLHLLL---LLVVLWIYGQKRFQRDIEFMLG-QPFASWKVFILRYTA 484

Human   687 TILTFILCFSFYQWEPMTYG-------SYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRF 744
            .|: |::|        |..|       .:.:....:|||.:::....:.||......:..:||.|
  Fly   485 PIV-FLIC--------MILGIIECIRVHFFFKEVFLVLGIILVVLPFLAIPGYGFYYLRQSPGTF 540

Human   745 IERLKLVCSPQPDWGPFLAQHR---GERYKN--MIDPL 777
            :||||..|.| .||.|...:||   |:|..|  |.|.|
  Fly   541 LERLKRSCRP-TDWYPVEMKHRQHYGDRVGNIEMTDHL 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118
		SLC6sbd_GlyT2	191..787	CDD:271389	164/623 (26%)
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	135/532 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810