DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DYRK1B and Hipk

DIOPT Version :9

Sequence 1:	NP_004705.1	Gene:	DYRK1B / 9149	HGNCID:	3092	Length:	629	Species:	Homo sapiens
Sequence 2:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster

Alignment Length:	666	Identity:	195/666 - (29%)
Similarity:	282/666 - (42%)	Gaps:	174/666 - (26%)

- Green bases have known domain annotations that are detailed below.

Human     4 PPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKK 68
            |.|.||.|..  ...||:|                 |||.             .|.|
  Fly   137 PDGIGPISSL--KTAHTKV-----------------ATSG-------------GHAN-------- 161

Human    69 RRAQQAPPQDSSNKKEKKVLNHGYDDD----NHDYIVR-SGERWLERYEIDSLIGKGSFGQVVKA 128
               .|.|.:.||:         |.|.|    .|:.:.. |.|     ||:...:|:|:||||||.
  Fly   162 ---TQPPSKRSSS---------GADGDYQLVQHEVLYSLSAE-----YEVLEFLGRGTFGQVVKC 209

Human   129 YDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELL 193
            :...|.|:|||||:||..::..|.|||:.:|..::|.:.: ::..|.....|..:||.|||||:|
  Fly   210 WKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEML 273

Human   194 SYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRS--AIK 256
            ..||||.|:...|..:.|...|.:.:|:.||||.|  .:|.:||.|||||||:|.:|.|.  .:|
  Fly   274 EQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKL--KQLGLIHADLKPENIMLVDPVRQPYRVK 336

Human   257 IVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVD 320
            ::||||:..:.:.:.. |:|||:||:||::||.|:..|||||||||::.|:..|.||:.||:|.|
  Fly   337 VIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFD 401

Human   321 QMNRIVEVLGIPPAAMLDQAPKARKYFER-----LPGGGWTLRRTKELRKDYQGPGTRRLQEV-- 378
            |:..|.:..|:|...||:.|.|..|:|.|     .|  .|.|:.|:|    ::.....:.:|.
  Fly   402 QIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYP--FWRLKTTEE----HEAETNTKSKEARK 460

Human   379 -----------LGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFR 432
                       :.|.|...||:...|    ..|...|.||:.|||..:...|::|..||.|.|.|
  Fly   461 YIFNCLDDIGQVNVPTDLEGGQLLAE----KTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTR 521

Human   433 RT--ADEATNTGPAGSSASTSPAPLDTC---------PSSSTASSISSSGGSSGSSSDNRTYRYS 486
            .|  .|..     ..::...|...::.|         |:|:..::...      ||::|.|:..:
  Fly   522 LTHLVDYV-----YCNNVKASVQMMEVCRRGDFHTVQPASTLVTNFVP------SSTENMTFTIN 575

Human   487 NRYCG------GPGPPIT-----------DCEMNSPQV---------------PPSQPLRPWAGG 519
            |:...      ..|.|:.           ......||.               |||....|
  Fly   576 NQLTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMP---- 636

Human   520 DVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCS-------- 576
             .|.| |....||:..|  ..|:||| :|: ..|.|.|...|......|:......|
  Fly   637 -SPTK-HVVVGSATMQP--PLQVPPQ-QYV-NVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTG 695

Human   577 ------PPHPAPAPQH 586
                  |..|..||.|
  Fly   696 RQMALVPSWPQQAPAH 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DYRK1B	NP_004705.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..89		4/21 (19%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	69..86		4/16 (25%)
		PKc_DYRK1	97..436	CDD:271128	135/362 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..399		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..629		40/206 (19%)
		Interaction with RANBP9. /evidence=ECO:0000269\|PubMed:14500717	480..520		11/71 (15%)
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	129/340 (38%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840