Protein Alignment NEMF and Clbn

DIOPT Version :10

• Sequence 1: NP_004704.3
• Gene: NEMF / 9147
• HGNCID: 10663
• Length: 1076
• Species: Homo sapiens
• Sequence 2: NP_651341.2
• Gene: Clbn / 43018
• FlyBaseID: FBgn0259152
• Length: 992
• Species: Drosophila melanogaster
• Alignment Length: 1118
• Identity: 506/1118 - (45%)
• Similarity: 684/1118 - (61%)
• Gaps: 179/1118 - (16%)

Human     1 MKSRFSTIDLRAVLAELNASLLGMRVNNVYDVDNKTYLIRLQKPDF--KATLLLESGIRIHTTEF 63
            ||:||:|.|:...:|||. .|:|.|||.:|||||||||.|:|....  |.|||:|||.|.|||.|
  Fly     1 MKTRFNTFDIICGVAELQ-KLVGWRVNQIYDVDNKTYLFRMQGTGAVEKVTLLIESGTRFHTTRF 64

Human    64 EWPKNMMPSSFAMKCRKHLKSRRLVSAKQLGVDRIVDFQFGSDEAAYHLIIELYDRGNIVLTDYE 128
            ||||||.||.|:||.|||||::||...:|:|.|||||||||:.:||||:|:|||||||::|||||
  Fly    65 EWPKNMAPSGFSMKLRKHLKNKRLEKVQQMGSDRIVDFQFGTGDAAYHVILELYDRGNVILTDYE 129

Human   129 YVILNILRFRTDEADDVKFAVRERYPLDHARAAEPLLTLERLTEIVASAPKGELLKRVLNPLLPY 193
            ...|.|||..| |.::::||:||:||::.|:.....|.||.|.:::.:|..|:.|:::|.|.|..
  Fly   130 LTTLYILRPHT-EGENLRFAMREKYPVERAKQPTKELELEALVKLLENARNGDYLRQILTPNLDC 193

Human   194 GPALIEHCLLENGFSGNV--------------------------KVDEKLETKDIEKV--LVSLQ 230
            |||:|||.||.:|...:|                          :.:.|||.|..:.|  |..||
  Fly   194 GPAVIEHVLLSHGLDNHVIKKETTEETPEAEDKPEKGGKKQRKKQQNTKLEQKPFDMVNDLPILQ 258

Human   231 K----AEDYMKTTSNFSGKGYIIQKREIKPSLEADKPVEDILTYEEFHPFLFSQHSQCPYIEFES 291
            :    |::.:...::...||||||.:|.||:  .:..||......||||:||.|........|||
  Fly   259 QAVKDAQELIAEGNSGKSKGYIIQVKEEKPT--ENGTVEFFFRNIEFHPYLFIQFKNFEKATFES 321

Human   292 FDKAVDEFYSKIEGQKIDLKALQQEKQALKKLDNVRKDHENRLEALQQAQEIDKLKGELIEMNLQ 356
            |.:|||||||..|.||||:|.||||::|||||.||:.||..|||.|.:.|::|:.|.|||..|..
  Fly   322 FMEAVDEFYSTQESQKIDMKTLQQEREALKKLSNVKNDHAKRLEELTKVQDVDRKKAELITSNQS 386

Human   357 IVDRAIQVVRSALANQIDWTEIGLIVKEAQAQGDPVASAIKELKLQTNHVTMLLRNPYLLSEEED 421
            :||.||:.|:||:|:|:.|.:|..:||||||.||.|||:||:|||:|||::::|.:||  ..:||
  Fly   387 LVDNAIRAVQSAIASQLSWPDIHELVKEAQANGDAVASSIKQLKLETNHISLMLSDPY--DNDED 449

Human   422 DDV-DGDVNVEKNETEPPKGKKKKQKNKQLQKPQKNKPLLVDVDLSLSAYANAKKYYDHKRYAAK 485
            ||: |.:|.|                              |||||:|||:|||::|||.||.||:
  Fly   450 DDLKDPEVTV------------------------------VDVDLALSAWANARRYYDMKRSAAQ 484

Human   486 KTQKTVEAAEKAFKSAEKKTKQTLKEVQTVTSIQKARKVYWFEKFLWFISSENYLIIGGRDQQQN 550
            |.:|||:|::||.||||:||:||||||:|:::|.|||||:|||||.|||||||||:|||||.|||
  Fly   485 KEKKTVDASQKALKSAERKTQQTLKEVRTISNIVKARKVFWFEKFYWFISSENYLVIGGRDAQQN 549

Human   551 EIIVKRYLTPGDIYVHADLHGATSCVIKNPTGEPIPPRTLTEAGTMALCYSAAWDARVITSAWWV 615
            |:|||||:.|.||||||::.||:|.:|:|||||.|||:||.|||:||:.||.||||:|:|:::||
  Fly   550 ELIVKRYMRPKDIYVHAEIQGASSVIIQNPTGEEIPPKTLLEAGSMAISYSVAWDAKVVTNSYWV 614

Human   616 YHHQVSKTAPTGEYLTTGSFMIRGKKNFLPPSYLMMGFSFLFKVDESCVWRHQGERKVRVQDEDM 680
            ...||||||||||||.||||||||||||||..:|.||.|.|||:::|.:.||.||||||..::|
  Fly   615 TSDQVSKTAPTGEYLATGSFMIRGKKNFLPSCHLTMGLSLLFKLEDSFIERHLGERKVRSLEDD- 678

Human   681 ETLASCTSELISEEMEQ---LDGGDTSSDEDKEEHETPVEV------ELMTQVDQEDITLQSGRD 736
                .....:...|:|.   .|..|..|:.:..|..:..|:      |:..:.|...|.::|  |
  Fly   679 ----QIDPNVKENEVEHDLLSDNEDADSNINLSEPSSNTEITAFPNTEVKIEHDTGRIIVRS--D 737

Human   737 ELNEELIQEESSEDEGEYEEVRKDQDSVGEMKDEGEETLNYPDTTIDLSHLQPQRSIQKLASKEE 801
            .:|.|:  ||:.|.|...:::.|..|      ||        :|||.|:....::.:....:||:
  Fly   738 SVNPEI--EETKESEVVLDKILKKTD------DE--------ETTIILAGPSRKKQVSAKKTKED 786

Human   802 SSNSSDSKSQSRRHLSAKERREMKKKKLPSDSGDLEALEGKDKEKESTVHIETHQNTSKNVAAVQ 866
                           .|:.::|..|:::|..|.:                       .||.:.|
  Fly   787 ---------------KARAKQEAAKQEVPPVSSE-----------------------PKNPSQV- 812

Human   867 PMKRGQKSKMKKMKEKYKDQDEEDRELIMKLLGSAGSNKEEKG--KKGKKGKTKDEPVKKQPQKP 929
              |||||.|:||||:||||||:|:||:.|.:|.|:|..|.:..  |..:|.::..|.||  |:|.
  Fly   813 --KRGQKGKLKKMKQKYKDQDDEEREIRMMILKSSGKEKPQASADKVVEKSESTKEYVK--PEKS 873

Human   930 RGGQRVSDNIKKETPFLEVITHELQDFAVDDPHDDKEEQDLDQ--QGNEENLFDSLTGQPHPEDV 992
            ..                             |.:..|..|.|:  .|.:.::.:|||||||..|.
  Fly   874 AA-----------------------------PKNPVELDDADEVPVGGDVDVLNSLTGQPHEGDE 909

Human   993 LLFAIPICAPYTTMTNYKYKVKLTPGVQKKGKAAKTALNSFMHSKEATAREKDLFRSVKDTDLSR 1057
            ||||||:.|||..:.|||:|||||||..|:|||||.|||.|...|..:||||||.:|:|:..|:|
  Fly   910 LLFAIPVVAPYQALQNYKFKVKLTPGTGKRGKAAKLALNIFAKEKSCSAREKDLLKSIKEESLAR 974

Human  1058 NIPGKVKVSAPNL 1070
            |||||||:|||.|
  Fly   975 NIPGKVKLSAPQL 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEMF	NP_004704.3	RqcH_arch	6..644	CDD:469043	351/672 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..453		7/33 (21%)
		COG5137	<658..776	CDD:227466	33/126 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	691..715		6/26 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	742..972		56/231 (24%)
		NFACT-C	975..1066	CDD:432191	55/90 (61%)
Clbn	NP_651341.2	RqcH_arch	8..643	CDD:469043	350/670 (52%)
		PTZ00341	<654..>814	CDD:173534	49/223 (22%)
		NFACT-C	893..983	CDD:432191	55/89 (62%)