Protein Alignment RNF185 and sordd1

DIOPT Version :10

• Sequence 1: NP_689480.2
• Gene: RNF185 / 91445
• HGNCID: 26783
• Length: 192
• Species: Homo sapiens
• Sequence 2: NP_573076.1
• Gene: sordd1 / 32532
• FlyBaseID: FBgn0030693
• Length: 277
• Species: Drosophila melanogaster
• Alignment Length: 223
• Identity: 118/223 - (52%)
• Similarity: 137/223 - (61%)
• Gaps: 37/223 - (16%)

Human     6 PSASASPENSSA------------------GGPSGSSNGAGESGG------------------QD 34
            |..::.|.||:|                  ||......|....||                  .|
  Fly    56 PLGTSIPTNSTASELKKSNTSYSFTGDYLSGGNKADLKGGYPFGGTDTDTKANEKDKEKEHTADD 120

Human    35 STFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQ 99
            |.:|||||||||||||:|:||||||||||||||.|||||::||||||.:.:|||||||||.||.|
  Fly   121 SLYECNICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQ 185

Human   100 QDPREKTPPRPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG 164
            :|||.|.||||.|||.||:...||.|||||| ||.|||||||||||...:..|..:.|||.|..|
  Fly   186 EDPRNKVPPRPAGQRTEPDPVPGFPGFGFGD-GFHMSFGIGAFPFGFITSTLNFGEPRPPAANRG 249

Human   165 TPQYVDEQFLSRLFLFVALVIMFWLLIA 192
            |.||.|||.||:||.::|:|.:.||..|
  Fly   250 TRQYEDEQTLSKLFSYLAVVWILWLFYA 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF185	NP_689480.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		8/41 (20%)
		Required for ubiquitin ligase activity and protection against ER stress-induced cell death. /evidence=ECO:0000269|PubMed:27485036	29..80		40/68 (59%)
		RING-HC_RNF185	37..93	CDD:438402	45/55 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..123		21/32 (66%)
sordd1	NP_573076.1	RING-HC_RNF185	123..179	CDD:438402	45/55 (82%)