DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF185 and CG32581

DIOPT Version :9

Sequence 1:	NP_689480.2	Gene:	RNF185 / 91445	HGNCID:	26783	Length:	192	Species:	Homo sapiens
Sequence 2:	NP_001096988.2	Gene:	CG32581 / 318098	FlyBaseID:	FBgn0052581	Length:	283	Species:	Drosophila melanogaster

Alignment Length:	223	Identity:	109/223 - (48%)
Similarity:	132/223 - (59%)	Gaps:	40/223 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     6 PSASASPENSSA------------------GGPSGSSNGAGESGG------------------QD 34
            |..::.|.||:|                  ||......|....||                  .|
  Fly    56 PLGTSIPTNSTASELKKSNTSYSFTGDYLSGGNKADLKGGYPFGGTDTDTKANEKDKEKEHTADD 120

Human    35 STFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQ 99
            |.:|||||||||||||:|:||||||||||||||.|||||::||||||.:.:|||||||||.||.|
  Fly   121 SLYECNICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQ 185

Human   100 QDPREKTPPRPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG 164
            :|||.|.||||.|||.||:...||.|||||| ||.|||||||||||...:..|..:.|||..:
  Fly   186 EDPRNKVPPRPAGQRTEPDPVPGFPGFGFGD-GFHMSFGIGAFPFGFITSRLNFFEPRPPADI-- 247

Human   165 TPQYVDEQF-LSRLFLFVALVIMFWLLI 191
            ...:.||.: ||:||....:.:::.||:
  Fly   248 RRLHEDEPWALSKLFWHFVVFVIYGLLV 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF185	NP_689480.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		8/41 (20%)
		Required for ubiquitin ligase activity and protection against ER stress-induced cell death. /evidence=ECO:0000269\|PubMed:27485036	29..80		40/68 (59%)
		RING-HC_RNF185	38..80	CDD:319658	36/41 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..123		21/32 (66%)
CG32581	NP_001096988.2	RING	124..169	CDD:238093	39/44 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152552
Domainoid	1	1.000	138	1.000	Domainoid score	I4857
eggNOG	1	0.900	-	-		E1_COG5574
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34298
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3357
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1510545at2759
OrthoFinder	1	1.000	-	-		FOG0000717
OrthoInspector	1	1.000	-	-		otm42177
orthoMCL	1	0.900	-	-		OOG6_102074
Panther	1	1.100	-	-	O	PTHR12313
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R146
SonicParanoid	1	1.000	-	-		X682
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790