DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARHGEF1 and Exn

DIOPT Version :9

Sequence 1:	NP_945353.1	Gene:	ARHGEF1 / 9138	HGNCID:	681	Length:	927	Species:	Homo sapiens
Sequence 2:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster

Alignment Length:	832	Identity:	177/832 - (21%)
Similarity:	277/832 - (33%)	Gaps:	270/832 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   126 RVPVPP---NVAFELDRTRADLIS------------------------------EDVQRR--FVQ 155
            |:|.||   |..:|..|...|.||                              |||...  |..
  Fly  1190 RLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKLYENTPASTLFYVECSKRTEDVYENTDFGP 1254

Human   156 E---------VVQSQQVAV-------GRQLEDFRSKRLMGMTPWEQELAQLEA-----WVGRDRA 199
            |         .|..:|..|       |:.|.....|.|:|.:...::|:.|..     :|.....
  Fly  1255 ERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEG 1319

Human   200 SYEA----RERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFF 260
            |..|    .|.|.:..|.....:...|...:..|.:.|            .|....:.|:.|
  Fly  1320 SLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTV------------ARKAKKEAKANR--- 1369

Human   261 RKKVMGNRRSD--EPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMP 323
            |:..:|.|.:|  .|.....|..|.||..|                |:|||:..:...:.||...
  Fly  1370 RRTTIGLRPNDPPPPPPPMTGNKSPLDPER----------------ELDAEQTTSWYAECGVFKQ 1418

Human   324 SRDRNIGAPGQD--TPGVSLH----------------PLSLDSPDREPGADAPLE--LGDSSPQG 368
            :.:..:...|.:  ||..|.|                .:|:.|.....|.....|  |||.....
  Fly  1419 ATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSE 1483

Human   369 PMSLESLAPPESTDEGAETES------------------------PEPGDEGEPGRSGLEL-EPE 408
            |.||.|..|.......|:.||                        |||..:..|  :.|:| ||:
  Fly  1484 PHSLFSNEPLYQMYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRP--TALQLVEPK 1546

Human   409 EPPG---WRELVPPDTLHS-----LPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECL 465
            ..|.   |.|:  |:.:||     |...:...||...|::.:||::::.|.:|...|..
  Fly  1547 NGPSRTLWSEI--PEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMN------ 1603

Human   466 FFPLEELQNIFPSLDELIEVHSLFLDRLM----KRRQESGYL--IEEIGDVLLARFDGAEGSW-- 522
                                |:.|||..:    .|:....|:  :.|..:.||...   |..|
  Fly  1604 --------------------HNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTEL---EACWQD 1645

Human   523 ----------FQKISSR-------FC---SRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRL 567
                      ..:|:.|       ||   .|....|.:|| :.::...|...::..|:.|.|..|
  Fly  1646 NIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLK-ESKESLAFQQHLERLEASPSCCGL 1709

Human   568 QLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVE---LAAECCREILHHVNQAVRDMEDLLR 629
            .|...:...|||:|:.|||:.:: .:.|.|..||:.|   |.....::::...|:|....|....
  Fly  1710 NLHSFLMLPMQRITRLPLLIDAV-FSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFE 1773

Human   630 LKDYQRRLDL-SHLRQSS-----DPMLSEFKNLDITKKKLVH------EGPLTW--RVTKDKAVE 680
            |:...|:|:. ||:|..:     .|.........:.:.:|.|      :..||:  |:||   :.
  Fly  1774 LERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTK---IS 1835

Human   681 VHVLLLDDLLLLLQRQDER-------------LLLKSHSRTLTPTPD-----GKTMLRPVLRLTS 727
            ::..|..|||||.:|:.|.             .|....|....||.|     ||.::
  Fly  1836 IYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLI-------- 1892

Human   728 AMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALI----TETAG 775
            .||           :|...|::.....|...:||:::.|...:    .||.|
  Fly  1893 LMT-----------LLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPG 1933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARHGEF1	NP_945353.1	RGS_p115RhoGEF	67..259	CDD:188709	37/192 (19%)
		Trypan_PARP	<330..425	CDD:114603	34/147 (23%)
		RhoGEF	435..619	CDD:214619	44/214 (21%)
		PH_p115RhoGEF	653..777	CDD:275429	33/153 (22%)
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	44/212 (21%)
		PH_ephexin	1805..1931	CDD:269929	30/147 (20%)
		SH3_ephexin1_like	1944..1998	CDD:212727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810