Protein Alignment CCNB2 and CycB

DIOPT Version :10

• Sequence 1: NP_004692.1
• Gene: CCNB2 / 9133
• HGNCID: 1580
• Length: 398
• Species: Homo sapiens
• Sequence 2: NP_726244.1
• Gene: CycB / 37618
• FlyBaseID: FBgn0000405
• Length: 530
• Species: Drosophila melanogaster
• Alignment Length: 449
• Identity: 157/449 - (34%)
• Similarity: 226/449 - (50%)
• Gaps: 96/449 - (21%)

Human    19 GVNSKVKSHVTIRRTVLEEIGNRVTTRAAQVAKKAQNTKVPVQPTKTTNVNKQLKPT-------- 75
            ||::.::|:         .:.|||.|:..     .:.|||.|:.:.:.|||   :||
  Fly   106 GVSAFLRSN---------SVRNRVPTKTT-----VEPTKVTVKSSSSENVN---EPTLKREDSNL 153

Human    76 ----------ASVKPVQMEKLAPKGPSPTPEDVSMKE----ENLCQAFSDAL------------- 113
                      |..|||    :...|....|..||.||    :.|.:...|:|
  Fly   154 SKKSLTKLRAALAKPV----MGVSGIRREPVAVSRKEAETKKELPETKKDSLEVKKDATRMPLIR 214

Human   114 ----------------------LCKIEDIDNEDWENPQLCSDYVKDIYQYLRQLEVLQSINPHFL 156
                                  |..|||||..|.||..|.|:||.|||.||.|:|:.|.|:...|
  Fly   215 GNSAVTTTTSTMPTTMSLSSKRLAGIEDIDANDKENLVLVSEYVNDIYDYLYQVELEQPIHKDHL 279

Human   157 DG-RDINGRMRAILVDWLVQVHSKFRLLQETLYMCVGIMDRFLQ-VQPVSRKKLQLVGITALLLA 219
            .| ::::.:|||:|:||:.:||.:|.|..||..:.|.|:||:|| |:...|..|||||:|||.:|
  Fly   280 AGQKEVSHKMRAVLIDWINEVHLQFHLAAETFQLAVAIIDRYLQVVKDTKRTYLQLVGVTALFIA 344

Human   220 SKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFELGRPLPLHFLRRASKAGEVDVEQH 284
            :||||:|.|.|.|||:|||:.||:.|||:||..|.|.:...|.||||:|||||.|||...:.|.|
  Fly   345 TKYEELFPPAIGDFVFITDDTYTARQIRQMELQIFKAIDCNLSRPLPIHFLRRYSKAAGAEDEHH 409

Human   285 TLAKYLMELTLIDYDMVHYHPSKVAAAASCLSQKVL------GQG----KWNLKQQYYTGYTENE 339
            |::||.:||..:||:|..|.||::|||:..||..:|      |.|    .|.....:|:.|:...
  Fly   410 TMSKYFIELASVDYEMATYRPSEIAAASLFLSLHLLNGNHRAGTGFNDRHWTPTLTFYSRYSAAH 474

Human   340 VLEVMQHMAKNVVKVNENLTKFIAIKNKYASSKLLKISMIPQLNSKAVKDLASPLIGRS 398
            :..:.:.:||  :..:....|..||.|||..||..||::..:|...    |...::|:|
  Fly   475 LRPITRLIAK--LARDAPQAKLKAIYNKYQGSKFQKIALRTELTGA----LMDSIVGQS 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCNB2	NP_004692.1	CYCLIN_CCNB2_rpt1	127..259	CDD:410269	67/133 (50%)
		CYCLIN_CCNB2_rpt2	264..382	CDD:410273	47/127 (37%)
CycB	NP_726244.1	CYCLIN_CCNB1-like_rpt1	254..384	CDD:410211	65/129 (50%)
		CYCLIN_CCNB1-like_rpt2	389..509	CDD:410213	45/121 (37%)