DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ4 and KCNQ

DIOPT Version :9

Sequence 1:	NP_004691.2	Gene:	KCNQ4 / 9132	HGNCID:	6298	Length:	695	Species:	Homo sapiens
Sequence 2:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster

Alignment Length:	811	Identity:	310/811 - (38%)
Similarity:	413/811 - (50%)	Gaps:	191/811 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    19 PRAELVALTAVQSEQGEA--GGGGSPR----RLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAH 77
            |..::.|...::..:|:.  |...|.|    |:.|||.||.                ..|.:...
  Fly     3 PDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMSLLGKPLN----------------YNRGTRRD 51

Human    78 KRYRRLQNWVYNVLERPRG-WAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIV 141
            .||||||:.:||.|||||| .|..|||.:||:||:||.|||.|||:|::|.|...|..:|.::::
  Fly    52 VRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYILFRMEILVVI 116

Human   142 VFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSM 206
            .|.:|:..|:||:||..||:|..||.:|.::|||:||.:..:||:.|:..||.|.:|||||||.:
  Fly   117 WFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGL 181

Human   207 RFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYA 271
            ||.|||||||||||||||||||||||||.:||||..|||||.|||||||||:.|||.|..||::|
  Fly   182 RFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNFA 246

Human   272 DSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFE 336
            .:||||.|||.|:||||..|.||.|:::|:..||||||||||||||||||||||||:|.||||..
  Fly   247 QALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMI 311

Human   337 KRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPS--FRELALLFEH----------VQRA 389
            :||.|||.||||.||.|:.| ..:...|||..:...|||  ....:..|:|          ::|.
  Fly   312 RRRQPAATLIQAVWRCYAAD-EHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRH 375

Human   390 RN------GGLRPLEVRRAPVPDGAPSRYPPV-------------------------------AT 417
            ::      ||.....|.:.|....|.:||...                               .|
  Fly   376 KSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLEVVQNGKSMNPSFSEDSVAETT 440

Human   418 C---------HRPGSTSFCPGESS---------RMGIKDRIRMG---------SSQRRTGPSKQH 455
            |         .:|.:.:.|...||         |...:|:.|.|         ..|.:.|.|:::
  Fly   441 CLKNIKNSDASQPATLANCKLSSSAGSLAQFPDRNRDRDQDRRGHGEGEGDQAEEQAKAGGSRRN 505

Human   456 LAPPTM-------------------PTSPSSEQVGEA-TSPTKVQKSWSFNDRTRFRASLRLKPR 500
            |..|.:                   ..:|::::..|| ....:|.|.......|   ..|.:||
  Fly   506 LTIPVVLYGFLHGNFLGSTLSLRNPRVAPANDRDLEAGRDEDEVHKDTCQRSNT---LPLPVKP- 566

Human   501 TSAEDAPSE-----------------------------EVAEEKSYQCELTVDDIMPAVKTVIRS 536
                |:||.                             :||.|:.   |.....:....||.||.
  Fly   567 ----DSPSGSPGSGRTGRFFAAASHFLETGFSSPNPIIDVANEED---EPRCTQLTNRHKTAIRF 624

Human   537 IRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGD 601
            ||.||:.||:|||||.|:|||||||:|||:|||:|:|||:|.|..|:|||:|:         :|.
  Fly   625 IRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQILGK---------QGS 680

Human   602 KGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFY----SRCLRSGTSASLGAVQVPLFDP 662
            |...  ....:||:..||||||:||..||.|||:|:..|    .|.|         |:.:|. .|
  Fly   681 KAKD--VYASKISLASRVVKVERQVADIEEKLDILIKAYMEDRDRFL---------ALPLPA-KP 733

Human   663 DI--TSDYHSPVDHED----ISVSAQTLSIS 687
            .|  .|..|.|:.|..    |.|..:|.::|
  Fly   734 KIHSISPSHKPLHHAHNLAMIDVWKRTAALS 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ4	NP_004691.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		1/1 (100%)
		MIG-14_Wnt-bd	<92..190	CDD:284153	47/98 (48%)
		Ion_trans	126..330	CDD:278921	128/203 (63%)
		Ion_trans_2	246..320	CDD:285168	50/73 (68%)
		Selectivity filter. /evidence=ECO:0000250	283..288		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..480		22/157 (14%)
		KCNQ_channel	474..653	CDD:281513	74/211 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..515		7/47 (15%)
		A-domain (Tetramerization)	546..650		51/107 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..606		3/18 (17%)
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	128/204 (63%)
		Ion_trans_2	221..295	CDD:285168	50/73 (68%)
		KCNQ_channel	<619..719	CDD:281513	59/110 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1392
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	521	1.000	Inparanoid score	I1271
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168835at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40696
orthoMCL	1	0.900	-	-		OOG6_102886
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4953
SonicParanoid	1	1.000	-	-		X604
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860