DRSC/TRiP Functional Genomics Resources

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Protein Alignment FAM50A and CG12259

DIOPT Version :10

Sequence 1:NP_004690.1 Gene:FAM50A / 9130 HGNCID:18786 Length:339 Species:Homo sapiens
Sequence 2:NP_651595.1 Gene:CG12259 / 43347 FlyBaseID:FBgn0039557 Length:359 Species:Drosophila melanogaster


Alignment Length:355 Identity:221/355 - (62%)
Similarity:286/355 - (80%) Gaps:19/355 - (5%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAQYKGAASEAGRAMHLMKKREKQREQMEQMKQRIAEENIMKSNIDKKFSAHYDAVEAELKSSTV 65
            ||.|||||||||||..||||||.|::::|..|::| ||.:....|:.||:.||||||.:|||||:
  Fly     1 MAHYKGAASEAGRAAQLMKKREIQQQEIEFRKKKI-EEELKLDKIENKFATHYDAVEQQLKSSTI 64

Human    66 GLVTLNDMKAKQEALVKEREKQLAKK--EQSKELQMKLEKLREKERKKEAKRKISSLSFTLEEEE 128
            |||||::||||||.:|:||||:||:|  |:.:|.|..||.::.::.|:  ||:|.:|||.|:::|
  Fly    65 GLVTLDEMKAKQEDIVREREKKLAQKKDEKDREKQRALEAIQAEKNKQ--KRQIQALSFNLDDDE 127

Human   129 EGGEEEEE------AAMYEE--------EMEREEITTKKRKLGKNPDVDTSFLPDRDREEEENRL 179
            |..||::|      ..:.:|        |::.:.:..||:|:.|||||||||||||:|||:||||
  Fly   128 EEEEEDDEDHDKKQLKIKQEDQPKPKWTEIKEDILPIKKKKICKNPDVDTSFLPDREREEQENRL 192

Human   180 REELRQEWEAKQEKIKSEEIEITFSYWDGSGHRRTVKMRKGNTMQQFLQKALEILRKDFSELRSA 244
            ||:|||||..:|.::|.|:|.|||||||||||||.|.|:|||::.|||||.||:|||:|.||::.
  Fly   193 REQLRQEWVMQQAELKDEDISITFSYWDGSGHRRNVLMKKGNSIYQFLQKCLELLRKEFIELKTV 257

Human   245 GVEQLMYIKEDLIIPHHHSFYDFIVTKARGKSGPLFNFDVHDDVRLLSDATVEKDESHAGKVVLR 309
            ..:||||:|||||:|||:||||||||||||||||||.||||||||::|||:|||:|||||||:||
  Fly   258 MADQLMYVKEDLILPHHYSFYDFIVTKARGKSGPLFQFDVHDDVRMISDASVEKEESHAGKVLLR 322

Human   310 SWYEKNKHIFPASRWEPYDPEKKWDKYTIR 339
            ||||:|||||||||||||||.|.:|||||:
  Fly   323 SWYERNKHIFPASRWEPYDPTKSYDKYTIK 352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FAM50ANP_004690.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31 21/29 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 121..177 29/69 (42%)
XAP5 <152..338 CDD:461480 141/185 (76%)
Nuclear localization signal. /evidence=ECO:0000255 152..155 2/2 (100%)
CG12259NP_651595.1 PTZ00121 <5..>199 CDD:173412 102/196 (52%)
XAP5 110..351 CDD:461480 156/242 (64%)

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