Protein Alignment SMC3 and smc-3

DIOPT Version :10

• Sequence 1: NP_005436.1
• Gene: SMC3 / 9126
• HGNCID: 2468
• Length: 1217
• Species: Homo sapiens
• Sequence 2: NP_001255118.1
• Gene: smc-3 / 176559
• WormBaseID: WBGene00004873
• Length: 1205
• Species: Caenorhabditis elegans
• Alignment Length: 1249
• Identity: 503/1249 - (40%)
• Similarity: 767/1249 - (61%)
• Gaps: 76/1249 - (6%)

Human     1 MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALL 65
            |.||:|.|.|||||:|.|.|..||.:.||:||||||||||||:|||||||||::||:.||||.||
 Worm     1 MKIKEVRITGFRSYKDNTNVSGFSPRSNVVVGRNGSGKSNFFHAIQFVLSDEYAHLKEEQRLGLL 65

Human    66 HEGTGPRVISAFVEIIFDNSDNRL-PIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAG 129
            ||.|||:|..|.|||.||||:.|| ..:..||.:.|.:|.|||||::|.|||.:.:|:||:||||
 Worm    66 HESTGPKVAHARVEITFDNSEKRLMAFENSEVKIVRQVGKKKDQYYIDNKMVPRAEVVNLMESAG 130

Human   130 FSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLK 194
            ||||||||||||||||::||:||:.:||||||||||||||||||||:.::|||:.|.|||..|||
 Worm   131 FSRSNPYYIVKQGKINELATSPDAYKLKLLREVAGTRVYDERKEESLKILKETKMKTEKIQGLLK 195

Human   195 YIEERLHTLEEEKEELAQYQKWDKMRRALEYTIY---NQELNETRAKLDELSAKRETSGEKSRQL 256
            ||:|||.|||.|||:|.:|||.||.:|::|||:|   |:|..:.:.|||          |:..:|
 Worm   196 YIDERLQTLENEKEDLKEYQKLDKTKRSVEYTMYDNTNKEAIKEKTKLD----------EQKVEL 250

Human   257 RDAQQDARDKMEDIERQVRELKT---KISA----MKEEKEQLSAERQEQIKQRTKLELKAKDLQD 314
            .....:.:.::.|:..::.:|||   |:.:    ::|:||.|.||..:.::::..|:|:...|.:
 Worm   251 NQKDNNVKSQLNDVIAEMAKLKTDKKKLESLGRGLREDKETLQAEETKMVEEKMTLKLEIDSLNE 315

Human   315 ELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQ 379
            |.....:.|:......|.:.::|.:.::||...:|::..:.|:|.|....:........::.|||
 Worm   316 ENTRERQGRQNAEHSLQGVGDEIFKNEEELDTIKPEYAKLLEEESRLKTDIRIDESRAKEILAKQ 380

Human   380 GRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEV 444
            |:.|||:|.::|||:::.|::.:...|.|.|.:...|.|:|.|.|...||...:...:.:.::|.
 Worm   381 GQRSQFSSVDDRDKFLRNEIRRISGLIADNKEREETIQKELADVEREDEKLNNEIQSISRTIDEN 445

Human   445 KARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGI 509
            :..::....|...:|.:.|.....:....|||.|.:..:....:|:......||....:.:.|||
 Worm   446 RYEMDTFAAKSTSLKQEYDAAYVAQQTAAREEKAIRDKIGNTEQDISAANDQLRRIVARPVYNGI 510

Human   510 DSINKVLDHFR---RKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTK 571
            ..:.||::.|:   |.|.:..|.|||:|.|:...|....|.|.|||.|.||||||:|::|.::||
 Worm   511 TGVRKVIEEFKHDNRNGQHDDVINGYYGTVIELAEVPDMFRTAVEVIAQNRLFYHVVETDRIATK 575

Human   572 ILMEFNKMNLPGEVTFLPLNKLDV-RDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRS 635
            ||.:||:|.||||:.|.|:|::.. |.......::|.||...:.|..::||.||.:....:|.|:
 Worm   576 ILRKFNEMQLPGEINFFPMNRVSAPRQRDLSNNSNARPMSDVIDYEVQYDKVFKSITANVIIVRT 640

Human   636 MEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENL 700
            ::.:.:..|....|.::::|||:|.:|.:|||:.|.::|:|||.....:..:||.||:..|.|..
 Worm   641 LDQAARDLRNEGFDVVSVDGDQMSKKGVMTGGFIDKKRSKLELHTQKDRFTKELAELQKSLAEAE 705

Human   701 RRNIERINNEIDQLMNQMQQIETQ-------QRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQR 758
            :...|| ..|.:::.|:|||.|.|       .|:...::::|..:..|:...::       ||:.
 Worm   706 KMVRER-TQEAEKIRNRMQQHENQIGDFHRKHRELTEAKNAISQQFYMVTSTKE-------PKKD 762

Human   759 SLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQ-------KRVDALNDEIRQLQQENRQLLN 816
            .|..::..|..:.:.:|:.:.|:|:::.|||:.:::       |:||.:..::..:.:....|::
 Worm   763 QLLGIKNHLRELLAQKENFEQEIGSNMSSQLTSDEEQTVKKLRKKVDEMTKQLATVSRRRMDLMH 827

Human   817 ERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSE 881
            .:..:|.::|:......|:|..|:|.:.......:.......||:..:.:|:..|::...::..:
 Worm   828 RKNAIENLLTKKLYKTKESLTARVDDISDNERRHKLENANAQLTSLLTRMESTRKQLATAISELQ 892

Human   882 DLDNSIDKTEAGIKELQKSMERWKNMEKEHMD-AINHDTKELEKMTNRQGMLLKKKEECMKKIRE 945
            |.:.   |.:|....:...:|:.:::||:..| .:.:|     |:|.::..:.:|:|:.:||:|.
 Worm   893 DYET---KEKALQINIDNVLEQQRDLEKQQADFQLQYD-----KITAKEDEVKQKREDSLKKMRL 949

Human   946 LGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRG 1010
            ||:||.:.|.|:|.:..::|.:||.:|..|||||.:||||||||::..|.|||:|.||..|..:.
 Worm   950 LGALPTDTFSKWQNVKPRELEKKLLECVNELKKYENVNKKALDQYMTASSQKEELTKRMAEQKKS 1014

Human  1011 YKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSG 1075
            ..||.||:.|||.||||||.||||||.|||.:||::|||.|:..:.|:     ..:.:|:.||
 Worm  1015 EDSIEELLKVLENRKYEAIDLTFKQVKKNFEQVFKQLVPHGRGKMQMR-----AREQRDDEEG-- 1072

Human  1076 ESERGSGSQSSVPSVDQFTGVGIRVSFTGKQG--EMREMQQLSGGQKSLVALALIFAIQKCDPAP 1138
                       :.||:.:.|:.:.|||....|  |.|||.|||||||||||||:||:||||||||
 Worm  1073 -----------INSVELYEGISVLVSFVSDDGDSETREMTQLSGGQKSLVALAIIFSIQKCDPAP 1126

Human  1139 FYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFRNKVSHIDVITA 1203
            ||||||||.||||||||:|:|||..|:..|||:|||||||||.:|:|||||:|||||||||.:|.
 Worm  1127 FYLFDEIDAALDAQHRKSVADMIQSLSDQAQFVTTTFRPELLATAEKFYGVRFRNKVSHIDSVTR 1191

Human  1204 EMAKDFVEDDTTHG 1217
            |.|.||||||||||
 Worm  1192 EQAYDFVEDDTTHG 1205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC3	NP_005436.1	SMC_N	2..1197	CDD:426784	485/1226 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..268		2/25 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1059..1090		3/30 (10%)
smc-3	NP_001255118.1	SMC_N	2..1185	CDD:481474	485/1226 (40%)