Protein Alignment SLC16A4 and CG13907

DIOPT Version :10

• Sequence 1: NP_004687.1
• Gene: SLC16A4 / 9122
• HGNCID: 10925
• Length: 487
• Species: Homo sapiens
• Sequence 2: NP_612069.1
• Gene: CG13907 / 38104
• FlyBaseID: FBgn0035173
• Length: 816
• Species: Drosophila melanogaster
• Alignment Length: 683
• Identity: 158/683 - (23%)
• Similarity: 253/683 - (37%)
• Gaps: 220/683 - (32%)

Human    16 DGGWGWMIVIHFFLVNVFVMGMTKTFAIF---FVVFQEEFEGTSEQIGWIGSIMSSLRFCAGPLV 77
            |||:||:|....|:.|:.|.|:..||.||   ||.:..|.:||   :.|:||::|.:...|||:|
  Fly    73 DGGYGWVICFASFMCNMIVDGIAYTFGIFLEEFVAYFHEGKGT---VAWVGSLLSGVYLSAGPIV 134

Human    78 AIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFKK 142
            :.:.:..|.:...|.|:.:....:::|:::|::..|..|.|.:.|.|...:|..|.|....||:.
  Fly   135 SALANKYGCRAVCIAGSIIACIAFVLSTFSTNVSMLMATYGFMGGFGFGMIYLPAVVAVGYYFET 199

Human   143 RLALSTAIARSGMGL-TFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPI-HIKSENN 205
            :.:|:|.||..|.|. ||..||...:|::.|.|..||::|..:.||......::||: :.|.:..
  Fly   200 KRSLATGIAVCGSGFGTFAFAPLATYLLEEYGWKNALLIFAGLILNCAIFGAMMRPLTYPKKKKQ 264

Human   206 SGIK-----------DKGSSLSAH--------------------GPEAHA--------------- 224
            ..:.           ::||...:|                    .|..|:
  Fly   265 KPLMQRMYEEKQLQLERGSFAGSHFMVQLPDGTIERKLKMPLNADPGVHSSLNLELLAQQAGGGG 329

Human   225 ----------TETHC----------------------------------HETEEST-----IKDS 240
                      ||:..                                  |...||.     .:|:
  Fly   330 LHPVSTLPTITESKVVDVHRQNGAQSPPNGDSNGQLSARSAAGAVGRRPHRNSESENSPYHSQDA 394

Human   241 TTQKAGLP--------------------------------------------------------S 249
            .|:.|..|                                                        |
  Fly   395 MTRNASQPAFLAGDHQSLPKNGSVPAFNTRVRKTSASERFQPSLAAIRATSRGDLEAGAGGDFAS 459

Human   250 KNLTVSQNQ-----------------SEEFYNG-----PN----------RNRLLL--------- 273
            ..|::||.|                 .:.||:|     |.          ||.:|.
  Fly   460 SKLSLSQRQGGSQTGSSGRMVRPMSRKDIFYSGSVTNLPQYQSQKSLANYRNSVLSLTKYEKSMQ 524

Human   274 ------------KSDEESDKV----ISWSCKQ----LFDISLFRNPFFYIFTWSFLLSQLAYFIP 318
                        |..||.|..    |..|.|.    :.|:||.::|.|.:...|.:......::|
  Fly   525 SVAKLDPLAEAEKHREEYDLCPCLGIPDSVKSVVNTMLDVSLLKDPVFMLIGVSNIFGMAGLYVP 589

Human   319 TFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYLILCGITNLLA 383
            ..:||..||...|...||:.|:|:.||..||.::..|||||...:.....:...|::..|...|.
  Fly   590 FVYLVDAAKEHDIPKNDAAMLLSIIGITNTVGRVFCGWVADLPQVNSLLLNNCCLLVSTIAVTLT 654

Human   384 PLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRNSTVNRFLGLASFFAGMAVLSGPPIAGWL 448
            ||..::...:|.:|.|.:...||::|...:||||.....:....||...|.|.|.|.|.|:||.:
  Fly   655 PLCYSYAAYITMSIFFGLAISGYISLTSIILVDLLGLDKLTNAFGLLILFRGFAALIGTPLAGAI 719

Human   449 YDYTQTYNGSFYFSGICYLLSSVSFFFVPLAER 481
            ||.|.||:..||.:|..:.:|:::.|..|..:|
  Fly   720 YDMTHTYDLPFYMAGALFGISTITSFLAPCLKR 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A4	NP_004687.1	MFS_MCT5	20..481	CDD:340979	154/677 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..250		14/194 (7%)
CG13907	NP_612069.1	MFS_MCT_SLC16	77..>260	CDD:340910	59/185 (32%)
		MFS	<566..748	CDD:475125	58/181 (32%)