Protein Alignment SLC16A4 and Targ

DIOPT Version :10

• Sequence 1: NP_004687.1
• Gene: SLC16A4 / 9122
• HGNCID: 10925
• Length: 487
• Species: Homo sapiens
• Sequence 2: NP_001286425.1
• Gene: Targ / 36630
• FlyBaseID: FBgn0033955
• Length: 859
• Species: Drosophila melanogaster
• Alignment Length: 570
• Identity: 115/570 - (20%)
• Similarity: 211/570 - (37%)
• Gaps: 111/570 - (19%)

Human    16 DGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGSIMSSLRFCAGPLVAII 80
            |||:||:|::..||..:.:.|:..|..:......::.:.:...:.::.|:.....|.:|...|::
  Fly   300 DGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVL 364

Human    81 CDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLP---GLGSAFLYQVAAVVTTKYFKK 142
            .:..|.:..:|.|........|.|||:.|:..|.....:|.   |:..:.::..:.::...||::
  Fly   365 INRFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVLACAGGITLSMIWASSQLIVGYYFER 429

Human   143 RLALSTAIARSGMGLTFLLAPF-TKFLIDLYDWTG---------ALILFGAIA-LNLVPSSMLLR 196
            ...::...:.||.|...:|..| ..:|:.:..|..         .|||...:| :.:.|:.:.:
  Fly   430 YRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQAGLIMLILLMVVAYVEVAPTQVGM- 493

Human   197 PIHIKSENNSGIKDKGSSLSAHGPEAHATETHCHETEESTIKDSTTQKA---GLPS------KNL 252
             .|:...:::...:...:...|.....:..|....:..||.:....:|.   ..||      :..
  Fly   494 -YHLPGSSDTSSDEYYGNFYVHDYLRQSAMTAKSRSILSTYEPRPKKKGCAKFCPSCSNCCWRRR 557

Human   253 TVSQNQSEE--------------FYNGP-------------NRNRLLLKSDEESDKV-------- 282
            ..|||..|:              ||.||             .:..||:.||:.:.:|
  Fly   558 KKSQNADEQNLLIRPAPLEREDLFYTGPAEYEKPHSKENVDGKEFLLMGSDKNTQQVNYGIKNIR 622

Human   283 -------IS-------W---------SCK---------QLFDISLFRNPFFYIFTWSFLLSQLAY 315
                   ||       |         ||:         :|||..|.:...|.|...|..|..:.:
  Fly   623 VDDEPDRISRVHRERRWSNENQKKQNSCRNSRFMLTVLKLFDYRLLKQFEFKILVASAFLFPMGF 687

Human   316 FIPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYLILCGITN 380
            .||..:..||..   |.:..|..:..:.||...|.:.|.|.:|       |......|.|||...
  Fly   688 NIPFVYSSARTT---IPVEYARMIGPIIGISNLVMRNILGILA-------YKRRSWTLGLCGCGL 742

Human   381 LLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRNSTVNRFLGLA---------SFFAGM 436
            :...::..........:.:..|..|:...:.|.:....|.....::|||:         |...||
  Fly   743 IFGGVSVLISAFYGENLIWFQFLYGFSYAVAPAVYSTLRGLIYVKYLGLSKLTNAFGITSLAMGM 807

Human   437 AVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAERWKNSL 486
            ....|..|||.|...|..|:.:|.|:|:|.::|......:||..:.:|.:
  Fly   808 GAFIGTTIAGKLIGITGNYSAAFCFAGLCLIVSGFLKLLLPLLIKCRNRM 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A4	NP_004687.1	MFS_MCT5	20..481	CDD:340979	111/559 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..250		7/52 (13%)
Targ	NP_001286425.1	MFS_MCT_SLC16	304..842	CDD:340910	109/549 (20%)