Protein Alignment SLC16A4 and CG8468

DIOPT Version :10

• Sequence 1: NP_004687.1
• Gene: SLC16A4 / 9122
• HGNCID: 10925
• Length: 487
• Species: Homo sapiens
• Sequence 2: NP_610940.1
• Gene: CG8468 / 36577
• FlyBaseID: FBgn0033913
• Length: 678
• Species: Drosophila melanogaster
• Alignment Length: 628
• Identity: 140/628 - (22%)
• Similarity: 235/628 - (37%)
• Gaps: 167/628 - (26%)

Human    16 DGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGSIMSSLRFCAGPLVAII 80
            |.||.|::::..||....:.|:.....:.......||..:...:.::.|::|.....|||.|:.:
  Fly    45 DSGWAWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAM 109

Human    81 CDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFKKRLA 145
            .:..|.:..:|.||......:.:|.:|||:.:|.:..|:|.|:|...:|..|.|:...||:|..|
  Fly   110 ANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRA 174

Human   146 LSTAIARSGMGL-TFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPIH---IKSENNS 206
            |:|.:|..|.|: ||:.||.||.|:. ..|...|.:.|.|.|:.....:..|||.   :...|..
  Fly   175 LATGVAMCGSGVGTFVFAPLTKILLK-SGWRYTLAIQGIIVLSCALFGLAFRPIQPITLSVTNEE 238

Human   207 GIKDKGSSLSAHG------PEAH---------------------------ATETHCHETEESTIK 238
            |.:.:...|:.||      |:.|                           |::.:.:.|.:...|
  Fly   239 GDEQEKKKLNGHGNTVAPTPQLHQAAFTKPLPEGRFAYSMPNSAHNTYMGASQRNHYPTAQEIFK 303

Human   239 DSTTQK---------AGLPSKNL------------------------TVSQNQSE---------- 260
            ....::         .|...|.|                        ||.:|:.|
  Fly   304 GMNLERRPSGTAQGSKGTELKQLRKSQPTTPNGDPQQLTFNLHKELTTVGENEEEAENDNLLETE 368

Human   261 ------------------------------EFYNGPNRN-------------------------- 269
                                          |.::|.:.:
  Fly   369 AKPVTIQARRHTVSGRRPQDIGKRSAAAAHEAHHGQSHSSSRPMYRDDIFFSGSLTRIPQYQSQT 433

Human   270 ---------RLLLKSDEESDK---------VISWSCKQLFDISLFRNPFFYIFTWSFLLSQLAYF 316
                     ||..|.|...|:         .:..:...:.|.:|.::|.|....:|..|:.:.:|
  Fly   434 SLAYHMSVTRLPTKQDMLEDRQKGCRICPEAVRRTLSTMLDTTLLKSPAFMCLAFSGFLTMMGFF 498

Human   317 IPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYLILCGITNL 381
            :|...||.|||..|:|...|..::|..|::.|.::|:.|.::....:|....:...|...||..:
  Fly   499 VPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLNNFALTAGGIATI 563

Human   382 LAPL----ATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRNSTVNRFLGLASFFAGMAVLSGP 442
            .:.:    ||.:...:.:.||.|.|:    ||...:.|:|.....:....|....|.|:|...|.
  Fly   564 CSGIVINTATQWTFALFFGICIACFS----ALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGS 624

Human   443 PIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPL--AERWK 483
            ||||.||..|.:||.:|||:|...|||  :|...||  ..||:
  Fly   625 PIAGGLYVMTGSYNAAFYFAGGLILLS--AFLCYPLTWVSRWE 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A4	NP_004687.1	MFS_MCT5	20..481	CDD:340979	135/620 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..250		10/85 (12%)
CG8468	NP_610940.1	MFS_MCT_SLC16	49..>225	CDD:340910	49/176 (28%)
		MFS	<477..658	CDD:475125	56/186 (30%)