Protein Alignment SLC16A4 and chk

DIOPT Version :10

• Sequence 1: NP_004687.1
• Gene: SLC16A4 / 9122
• HGNCID: 10925
• Length: 487
• Species: Homo sapiens
• Sequence 2: NP_610230.3
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Alignment Length: 754
• Identity: 152/754 - (20%)
• Similarity: 250/754 - (33%)
• Gaps: 295/754 - (39%)

Human    13 KTLDGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGSIMSSLRFCAGPLV 77
            |..|||:||::|....:|::...|::.:|.:..|...|.|..::.:..||.|:..|:....||:.
  Fly   131 KMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKTAWISSLFFSVPLLMGPIW 195

Human    78 AIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFKK 142
            :.:.|..|.:..:|||..|...|:.:||:..||..|.||.|::.|||....|..|.|....:|.|
  Fly   196 SNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWFDK 260

Human   143 RLALSTAIARSGMGL-TFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLR---------- 196
            :...:|.|..||.|: ||:.|..|.:||:.|.|.||.::.|...||......|:|
  Fly   261 KRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRDPDWLIEENR 325

Human   197 ----------------------------------------------------PI----------- 198
                                                                |:
  Fly   326 LESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPLDSALKRYRSEI 390

Human   199 ---------------HIKSENNSGIKDK--------------GSSLSAHGP-------------- 220
                           .:||.:...::.|              .|...|:.|
  Fly   391 FLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPSTAVIGSPDDTLMG 455

Human   221 ----------------------------------------------EAHAT-------------- 225
                                                          :.||:
  Fly   456 GIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHASSRYSLNENIFMAKH 520

Human   226 -----------------------ETHCH------------------------ETEESTIKDSTTQ 243
                                   :.||:                        |.|:|...:..|:
  Fly   521 TTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPEQEQSVNSELATR 585

Human   244 KAGLPS---------------------KNLTVSQ---------NQSEEFYNG------------- 265
            :|.|.|                     :|:::..         :::...|.|
  Fly   586 RARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYRGAMLNTHRYRLRAS 650

Human   266 --PN--RNRLLLKSDEESDKVISW------SCKQLFDISLFRNPFFYIFTWSFLLSQLAYFIPTF 320
              ||  ||.:...:.||.|   :|      :.|.:||.|||.:..|.:|..|.|...:.:.||..
  Fly   651 SCPNIYRNSMTTIAKEEED---TWYDNFVDTMKSIFDFSLFLDMKFALFNLSTLFLFIWFIIPYL 712

Human   321 HLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYLILCGITNLLAP- 384
            :|....|....|:..::.|:|..||.:||..|..|::.|.:|:.....:...:::||.:....|
  Fly   713 YLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGDLSWMNINICYSLCMLVCGASVFFMPL 777

Human   385 LATTFPLLMTYTICFAI-FAG--GYLALILPVLVDL----CRNSTVNRFLGLASFFAGMAVLSGP 442
            |.|.:..||...:.|.. ||.  .:...||..:|||    |.       .||.....|:.:::||
  Fly   778 LITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCA-------YGLVLLVQGVGMIAGP 835

Human   443 PIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAER 481
            ||||.:|:||..::.:||::||...||.|..:.:...|:
  Fly   836 PIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLIEFCEK 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A4	NP_004687.1	MFS_MCT5	20..481	CDD:340979	147/745 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..250		15/199 (8%)
chk	NP_610230.3	MFS_MCT_SLC16	138..>315	CDD:340910	57/176 (32%)
		MFS	<687..869	CDD:475125	56/188 (30%)