Protein Alignment SLC16A4 and CG8034

DIOPT Version :10

• Sequence 1: NP_004687.1
• Gene: SLC16A4 / 9122
• HGNCID: 10925
• Length: 487
• Species: Homo sapiens
• Sequence 2: NP_573376.2
• Gene: CG8034 / 32924
• FlyBaseID: FBgn0031011
• Length: 647
• Species: Drosophila melanogaster
• Alignment Length: 627
• Identity: 122/627 - (19%)
• Similarity: 223/627 - (35%)
• Gaps: 166/627 - (26%)

Human     3 KREGKVQPYTKTLDGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGS--I 65
            |:..||.|     ||||||:......|||:....:..:|.:.|....:|.     .:|..|:  |
  Fly     4 KQPRKVAP-----DGGWGWVACFGVSLVNLATRSIEPSFGLLFGDTLKEL-----NVGTTGAAVI 58

Human    66 MSSLRFC---AGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAF 127
            :|:|..|   :|..|..:......:..:|.|:.:...|..::|.|||:..:..|..::.|:|...
  Fly    59 ISALDVCMNFSGLFVGPLLKEFSYRKVAIAGSLLCGLGLALTSPATSMAHILSTYSVINGIGVGL 123

Human   128 LYQVAAVVTTKYFKKRLALSTAIARSGMGLTFLLAP-FTKFLIDLYDWTGALILFGAIALNLVPS 191
            ....|.|....|||.:...:..::.:|..:..|:.| ..:.|::.||:.||::|...:|||....
  Fly   124 STSAAFVALNHYFKHKRGQAVGLSMAGTAMGMLIMPQLVRILLEAYDFRGAVLLLAGVALNATVG 188

Human   192 SMLLRPI--HIKSE---------------------NNSG------------IKDKGSSLSA---- 217
            |:||:|:  |:|.|                     ..:|            ||:.|:...|
  Fly   189 SVLLQPVKWHMKEEFDDEELMCISALPTPQPQLTVGGAGGAASAGAPVFKVIKEDGNEEDALPEM 253

Human   218 --------HGPEAHATETHCHETEESTIKDSTTQKAGLPSK------------------------ 250
                    | |..|:...:..|...:|:..|   :.|:|.:
  Fly   254 NTLLFHKPH-PHQHSMRKNYSEMAMNTMNGS---RLGIPKRPTFPRIMSLAGVQSAAHGAGGDSG 314

Human   251 --------NLT--------VSQNQS-----------------EEFYN-----------------G 265
                    |.|        |:.|.|                 :||..                 |
  Fly   315 GYTSQAEVNATQLRCRKASVTSNLSYMDFTGSILQVHLNTGDDEFEQNDRELRRVGTATGSIVLG 379

Human   266 PNRNRLLLKSDEESDK------VISWSCKQ-------------LFDISLFRNPFF--YIFTWS-F 308
            .:|:..:.....|.||      .:....|:             |.||.:.::..|  .:|..| |
  Fly   380 GHRDSFIKMKPTELDKQAEAAAALDEEAKKKAKKPGFWRRFADLLDIDMLKDKMFLNLLFGLSIF 444

Human   309 LLSQLAYFIPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYL 373
            .::::.:.:.|....|   .||....|.::.:|:..|.:..::|:...:.|:..|||.......:
  Fly   445 YVAEMNFKMVTPFFFA---NLGYQKTDVAFCLSITAITDIAARIVLPPIFDRTTIKKRTIFLVSI 506

Human   374 ILCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRNSTVNRFLGLASFFAGMAV 438
            |...:|..:....|.:..||.:......|.|..|:.....:.:.|....:....|.......:.|
  Fly   507 IFVALTRSIMAEQTEWTQLMIWLSICGFFRGSALSNFTLTVSEYCSLEKLPSAFGWHLVGKALFV 571

Human   439 LSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAE 480
            ::..|:.|.:.|.|.:|....:...:|.::.:.::....|.|
  Fly   572 ITFGPLIGLIRDVTDSYPICIHTQSVCIMICATAWGIEYLVE 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A4	NP_004687.1	MFS_MCT5	20..481	CDD:340979	114/610 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..250		13/67 (19%)
CG8034	NP_573376.2	MFS	16..>193	CDD:475125	45/181 (25%)
		MFS	<428..609	CDD:475125	33/183 (18%)