Protein Alignment SLC16A4 and Mct1

DIOPT Version :10

• Sequence 1: NP_004687.1
• Gene: SLC16A4 / 9122
• HGNCID: 10925
• Length: 487
• Species: Homo sapiens
• Sequence 2: NP_477334.2
• Gene: Mct1 / 31198
• FlyBaseID: FBgn0023549
• Length: 626
• Species: Drosophila melanogaster
• Alignment Length: 580
• Identity: 150/580 - (25%)
• Similarity: 254/580 - (43%)
• Gaps: 115/580 - (19%)

Human    16 DGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGSIMSSLRFCAGPLVAII 80
            ||||||::|...|::::...|||.:|.||:..|.:.|........||.|||..:.|.:||:.:..
  Fly    30 DGGWGWVVVFGSFMIHIVTDGMTYSFGIFYNEFLDYFNEGKGYTAWIASIMVGVTFSSGPISSSF 94

Human    81 CDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFKKRLA 145
            .:..|.:..:|.|:.:.....::|.:|.::..|.:|:|...|||...:|..|.|..|:||:.:.:
  Fly    95 VNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGTGLGFGLIYLPAIVSVTQYFEAKRS 159

Human   146 LSTAIARSGMGL-TFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPI----------- 198
            |:|.||..|.|. ||:.||.|:|||..|.|.||:::.|.|.||.:....:.||:
  Fly   160 LATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGAMLIIGGIVLNCIIFGAMFRPLELEAPPQTPPN 224

Human   199 --------------------------------------------------------------HIK 201
                                                                          ::.
  Fly   225 TPSTPKLAKKSAIIDQNTTAAELEPLKVLPKDQYLQLPQRTDTAVSGGALCRSNSVGHNLKPNLN 289

Human   202 SENNSGIKDKGSSLSAHGPEAHATET-------HCHETEEST-IKDSTTQKA------------- 245
            :.:|..:..:|.:| ...|:|....|       .||...:.| ::|:..:::
  Fly   290 NNSNGAVNGQGPTL-VTPPQAVVKSTSNDDIARKCHSQLQLTPLRDAHRERSASGTMYRPDALYQ 353

Human   246 ----GLP----SKN-LTVSQNQSE--EFYNGPNRNRLLLKSDEESDKVISWSCK--------QLF 291
                .||    |:| |:.|.:.|.  :.|....::..:.:|.||:......:|.        ::.
  Fly   354 GSLHNLPDYVSSRNDLSRSMSGSGVIKRYGSLRQSNNVSQSQEEAKCCGCITCSKETRDTFAEMM 418

Human   292 DISLFRNPFFYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGW 356
            :.||.::..|.||:.|...:.:.:.:|..::||.|:||.:...|||||:|..|:..||.:||.|:
  Fly   419 NFSLLKDMVFVIFSVSNFCTSIGFNVPYLYVVAYAETLKLTKTDASYLISTIGVANTVGRIILGY 483

Human   357 VADQNWIKKYHYHKSYLILCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRNS 421
            ::|:.|:.:...:...|..||::..:.||...|..|..|...|....|.|:.|...:||||....
  Fly   484 ISDKPWVNRLLVYNVCLTACGVSTAMVPLCHDFQSLAFYCCVFGFTIGAYVGLTSVILVDLLGLD 548

Human   422 TVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAER 481
            .:....||...|.|:|...||||.||:||.|.:|..:|..:|:...:|.:..|.:|..:|
  Fly   549 KLTNAFGLLLLFQGIASFIGPPIGGWMYDLTDSYAPAFLMAGLMIAISGLVMFAIPPLQR 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A4	NP_004687.1	MFS_MCT5	20..481	CDD:340979	145/574 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..250		11/72 (15%)
Mct1	NP_477334.2	MFS_MCT_SLC16	34..604	CDD:340910	144/570 (25%)