DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCARF2 and drpr

DIOPT Version :9

Sequence 1:	NP_699165.3	Gene:	SCARF2 / 91179	HGNCID:	19869	Length:	871	Species:	Homo sapiens
Sequence 2:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	169/546 - (30%)
Similarity:	219/546 - (40%)	Gaps:	160/546 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    64 CCAGWRQQGDECGIAVCEGNSTCSENEVCVRP--GECRCRHGYFGANCDTKCPRQFWGPDCKELC 126
            |..||  .|..|.:. |:    |..|.|| .|  |:|.|..||.||.|...||..|:|.:|.|.|
  Fly   132 CPPGW--YGRNCSMQ-CD----CLNNAVC-EPFSGDCECAKGYTGARCADICPEGFFGANCSEKC 188

Human   127 SCHPHGQCEDVTGQCTCHA-------------RRWGARCEHACQCQH-GTCHPRSGACRCEPGW- 176
            .|...|:|..|:|:|.|..             .:.||:|:..|.||: |.|.|.:|||.|.|||
  Fly   189 RCENGGKCHHVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWT 253

Human   177 -------------------------------------------------------WGAQCASACY 186
                                                                   :|..|:..|.
  Fly   254 GDVCANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCD 318

Human   187 CSATSRCDPQTGACLCHAGW--------------WGRSCNNQCAC---NSSPCEQQSGRCQC--- 231
            |:..:.||...|.|:|:.||              :|..||..|.|   ::..|..::|.|||
  Fly   319 CANDAMCDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIG 383

Human   232 -------RERTF---GARCDRYCQCFRG-RCHPVDGTCACEPGYRGKYCREPCPAGFYGLGCRRR 285
                   |..||   |..|:..|.|..| :|.||:|||.|.||:||..|.|.|..|.:|..|..|
  Fly   384 WSSAQCTRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALR 448

Human   286 CGQCKGQQPCTVAEGRCLTCEPGWNGTKCDQPCATGFYGEGCSHRCPPCRDGHACNHVTGKCTRC 350
            | .|:....|....|:|| |..||...|||:||....:|:.|:..| .|.:..|||...|.|| |
  Fly   449 C-DCQNGAKCEPETGQCL-CTAGWKNIKCDRPCDLNHFGQDCAKVC-DCHNNAACNPQNGSCT-C 509

Human   351 NAGWIGDRCETKCSNGTYGEDCAFVCADC---GSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHG 412
            .|||.|:|||.||..|.:|.|||..| .|   .|..||..:|||:|.....|.||...|..|.:|
  Fly   510 AAGWTGERCERKCDTGKFGHDCAQKC-QCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYG 573

Human   413 ADCAQACSC-HEDTCDPVTGACHLETNQRKGVMGAGALLVLLVCLLLSLLGCCCA---------- 466
            .:|.:.|.| :..:|||.:|.|         :..||            ..|..||
  Fly   574 ENCDKVCRCLNNSSCDPDSGNC---------ICSAG------------WTGADCAEPCPPGFYGM 617

Human   467 -CRGKDPTRRPRPRRELSLGRKKAPH 491
             |:.:.|        |:..|.|...|
  Fly   618 ECKERCP--------EILHGNKSCDH 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCARF2	NP_699165.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		PHA03247	<534..871	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..871
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	3/44 (7%)
		DSL	<479..518	CDD:302925	16/40 (40%)
		DSL	<567..606	CDD:302925	14/59 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810