DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCARF2 and T01D3.1

DIOPT Version :9

Sequence 1:	NP_699165.3	Gene:	SCARF2 / 91179	HGNCID:	19869	Length:	871	Species:	Homo sapiens
Sequence 2:	NP_001256538.1	Gene:	T01D3.1 / 179859	WormBaseID:	WBGene00011326	Length:	3226	Species:	Caenorhabditis elegans

Alignment Length:	688	Identity:	149/688 - (21%)
Similarity:	221/688 - (32%)	Gaps:	224/688 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    33 LLWMLPDTVAPQELNPR--------GRNVCRAPGSQVPTCCAGWRQQGDECGIAV---CEGNSTC 86
            |..::|.|| |..||.:        .|..|:   ..:..|..|:  .|.:|.|.:   |.||..|
Worm  1091 LTTVVPVTV-PDSLNIKCAHLAYCSRRGTCK---EGICICPHGY--TGFDCSIPLFCNCSGNGLC 1149

Human    87 SENEVCVRPGECRCRHGYFGANCDTKCPRQFWGPDCKELCSCHPHGQCEDVTGQCTCHARRWGAR 151
            :...:|:      |..|:.|::|..        |.|  |.:|..||:|.. ...|.|.|...|..
Worm  1150 NLLNICL------CNDGWSGSDCSI--------PRC--LTNCTGHGKCIQ-PNSCECDAGWMGET 1197

Human   152 CE-HAC---QCQHGTCHPRSGACRCEPGWWGAQC-ASAC-YCSATSRCDPQTGACLCHAGWWGRS 210
            |. .:|   ||.||.| ..:|.|:||.||.|::| ...| .||....| .:.|.|.|...:.|..
Worm  1198 CSVTSCIDSQCTHGHC-GTNGLCKCEDGWQGSRCQIPLCNSCSLNGIC-TRPGFCSCFEDYGGSD 1260

Human   211 CNNQCACNSSPCEQQSGRCQCRERTFGARCDRYCQCFRGRCHPVDGTCACEPGYRGKYCREPCPA 275
            |:.   |....||               .||  ..|..|.|.|:..||:|..|:.|..| :.|
Worm  1261 CSK---CVGDSCE---------------ACD--FDCNHGICEPLTKTCSCAKGWMGGAC-DVC-- 1302

Human   276 GFYGLGCRRRCGQCKGQ------QPCTV------------AEGRCLTCEPGWNGTKC--DQPCAT 320
                     ..|:|:..      ||.|.            .||..:|..   |...|  .:...|
Worm  1303 ---------SIGKCENSSQIYYIQPPTAELEDVNTVVNVFGEGFPITNN---NSYICTFGRTSVT 1355

Human   321 GFYGEGCSHRCPPCRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAFVCADCGSGHCD 385
            |........|||...:.....||.|.........||: .|.|..:.|..:.|.
Worm  1356 GHRVSSALIRCPIPSNLTLGRHVFGVSQPGLLSAIGN-SEPKPIHFTLYDGCE------------ 1407

Human   386 FQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACSCHEDTCD--PVTGACHLETNQRKGVMGAGA 448
                ..||.....||.|  .||.|..|..|        |..:  |......|| :|:......|.
Worm  1408 ----PSLCQGSCVGPLC--ICPQGKTGIFC--------DVIEVLPTIDKRFLE-HQKANTAYEGV 1457

Human   449 LLVLLVCLL-------------LSLLGCCCACRGKDPTRRPRPRRELSL---------------- 484
            ..||::..:             |:.:.........:|...|.| .|:|:
Worm  1458 PYVLMLPTMASSVLRVNSSIPNLNFIASKGIVAWPEPIGSPDP-YEVSVTAFSPAGETTISWNIT 1521

Human   485 ----------------GRKKAPHRLCGRFSRISMKLP-RIPLRRQKLPKVVVAHHDLDNTLNCSF 532
                            |:.|...:|.|..:..|.|.| .|.:||..:...::|..|....:|..:
Worm  1522 VQPEYAVEVQNVTVDGGKAKLKGKLIGPAAASSRKNPVVIRVRRDDIVDEILAESDTFGDVNFEY 1586

Human   533 LEPPSGLEQPSPSWSSRASFSSFDTTDEGPVYCVPHEEAPAESRDPEVPTVPAEAPAPSPVPLTT 597
            :....|:               ::.|       :.|...|.:|..|...|:|
Worm  1587 IPMLPGI---------------YEVT-------MAHPNVPTDSIQPIRFTIP------------- 1616

Human   598 PASAEEAIPLPASSDSERSASSVEGPGGALYARVARRE 635
                  .:.||...:|..|:.:::         :::||
Worm  1617 ------DLNLPIIGESSNSSLTLD---------ISQRE 1639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCARF2	NP_699165.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		PHA03247	<534..871	CDD:223021	14/102 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..871		11/66 (17%)
T01D3.1	NP_001256538.1	Beta_helix	276..417	CDD:289971
		Beta_helix	392..544	CDD:289971
		Beta_helix	<739..848	CDD:289971
		Beta_helix	819..1004	CDD:289971
		EGF_2	<1143..1166	CDD:285248	8/28 (29%)
		EGF_2	<1175..1198	CDD:285248	8/23 (35%)
		DSL	<1188..1230	CDD:302925	17/42 (40%)
		EGF_2	1269..1299	CDD:285248	13/46 (28%)
		Cadherin_repeat	2692..2776	CDD:206637
		DUF4758	2952..3130	CDD:292572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910