DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCARF2 and F55H12.3

DIOPT Version :9

Sequence 1:	NP_699165.3	Gene:	SCARF2 / 91179	HGNCID:	19869	Length:	871	Species:	Homo sapiens
Sequence 2:	NP_492397.4	Gene:	F55H12.3 / 172702	WormBaseID:	WBGene00010134	Length:	2957	Species:	Caenorhabditis elegans

Alignment Length:	759	Identity:	175/759 - (23%)
Similarity:	233/759 - (30%)	Gaps:	260/759 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    72 GDECGIA--VCEG--------NSTCSENEVCVRPGECRCRHGYFGANCD-----------TKCPR 115
            |.|..||  :||.        |:.|.:|.....|...||...|.|.||:           ..|.:
Worm  1465 GIENAIATNLCESLDTLYAVPNTFCVQNPTSTTPSIHRCDFCYGGENCEFLNPPYQGGAWCICAQ 1529

Human   116 QFWGPDC--KELC--------SCHPHGQCEDVTGQCTCHARRWGARCEHA-----C-----QCQH 160
            .::|..|  .:.|        .|...|:|......|.|.:...||.||.|     |     .|..
Worm  1530 DWYGRQCDVSKFCFNGTNDNYICQNGGRCNKDLRLCECLSSFTGAFCETAIDESNCALDEKDCVF 1594

Human   161 GTCHPRSGA---CRCEPGWWG---AQCASAC-YCSATSRCDPQTGAC---------LC---HAGW 206
            |.|. |..|   |.|..|:..   ..|..|. .||..:.|. |.|.|         :|   .:||
Worm  1595 GLCR-RENAQVYCNCYDGYMKDSLGNCTLAWDMCSLNNPCQ-QNGYCNFNQNIGDEICDCTSSGW 1657

Human   207 WGRSC------NNQCAC-NSSPCEQ---QSGRCQCRERTFGARC-DRYCQCFRGRCHPVDGTCA- 259
            .|..|      :|...| ||..|..   ...||||.....|..| |....||...|.. .|||:
Worm  1658 LGDHCEIQPKLDNCLYCQNSVKCFDTFTNYSRCQCAPGFSGDYCSDLIDDCFFEPCFN-GGTCSI 1721

Human   260 -----------------CEPGYRGKYCRE----------------------------PCPAGFYG 279
                             |:.||.|..|..                            .|...|||
Worm  1722 FNYNTTTKVSIESYNCTCQTGYFGTNCESRIHPSCTDLITCQNGGTCQLTSFDTAVCQCTDQFYG 1786

Human   280 LGCRRRCG-QCKGQQPCTVAEGRCLTCE--PGWNGTKCDQPCATGFYGEGCSHRCPPCRDGHACN 341
            :.|.:.|. ||.....|..:....:.||  .|:..|:||:.|      :.|......|::...||
Worm  1787 IYCEKSCSEQCVHSSGCKQSSNGTVFCECYDGFTSTRCDEVC------DVCKANILLCQNSGTCN 1845

Human   342 HVTGKC--------TRCNAGWIGDRCETK---CSNGTYGEDCAFVCADCGSGHCDFQSGRCLCSP 395
            ..|..|        |.|...  .:.|||.   |.||               |.|:.::|.|:|.|
Worm  1846 STTQSCDCIDYFSGTYCERN--ENLCETNLVVCKNG---------------GTCNPKTGLCVCLP 1893

Human   396 GVHGPHC---------------------NVTCP--PGLHGADC---AQACSCH--EDTCDPVTGA 432
            ...|.:|                     |.||.  ||..|..|   .|.|:.:  ..|..|.
Worm  1894 DYTGDYCDNQIHSCSDINCFNGGTCIDYNATCACLPGTTGDRCQYLGQPCTIYLPNGTATPY--- 1955

Human   433 CHLETNQRKGVMGAGALLVLLVCLLLSLLGCCCACRGKDPTRRPRPRRELSL---------GRKK 488
            |   .|:.|             ||.|. .|..|.|.|.:...|   |.|.|.         |...
Worm  1956 C---LNEGK-------------CLDLP-NGAACDCSGTNFIGR---RCETSSSFNFNLVFNGMSY 2000

Human   489 APHRLCGRFSRISMKLPRIPLRRQKLPKVVVAHHDLDNTLNCSFLE--------PPSGLEQPSPS 545
            .|..:.|.||.:                 ::|...:     |||::        .||..::..|.
Worm  2001 TPDIVTGLFSNL-----------------IIAQFTV-----CSFIQYNHPTIDSNPSPADEILPP 2043

Human   546 WSSRASFSS------FDTTDEGPVYCVPHEEAPAESRDPEVPTVPAEAPAPSPVPLTTPASA--- 601
            |.|...:.|      ||  :.|...|....:. ..|......|.|..|.......|.:||:|
Worm  2044 WLSIRGYGSNSQQIVFD--NNGFFICDVGRQC-NRSVQNNFKTTPITANTWHHFCLVSPANAISP 2105

Human   602 EEAIPLPASSDSERSASSVEGPGGALYARVARREARPARARGEI 645
            ...:.|......|:.|.:. .||...:..:|..:..|:|..|.|
Worm  2106 SYTVYLDGLLVWEQYAETF-NPGEYAHLLLAPADLTPSRFVGMI 2148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCARF2	NP_699165.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		PHA03247	<534..871	CDD:223021	28/129 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..871		18/79 (23%)
F55H12.3	NP_492397.4	LDLa	185..217	CDD:238060
		CCP	604..651	CDD:214478
		EGF_CA	851..884	CDD:214542
		CCP	<1066..1110	CDD:153056
		EGF_2	1831..1862	CDD:285248	7/30 (23%)
		EGF_2	1869..1900	CDD:285248	13/45 (29%)
		HYR	2235..2315	CDD:280629
		TNFRSF	2510..2657	CDD:304602
		GCC2_GCC3	2517..2567	CDD:285001
		CRD2	2530..2590	CDD:276900
		GCC2_GCC3	<2640..2676	CDD:285001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910