DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment L3MBTL4 and l3mbtl1b

DIOPT Version :9

Sequence 1:	XP_011524059.1	Gene:	L3MBTL4 / 91133	HGNCID:	26677	Length:	651	Species:	Homo sapiens
Sequence 2:	XP_009290632.1	Gene:	l3mbtl1b / 559572	ZFINID:	ZDB-GENE-100922-38	Length:	786	Species:	Danio rerio

Alignment Length:	609	Identity:	273/609 - (44%)
Similarity:	371/609 - (60%)	Gaps:	85/609 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     2 KQPNRKRKLNMDSKERLDQDGRLEQAEEEKKPKDS------------TTPLSHVPSAAAQGAWSW 54
            |:..:|:|:.|:|::  :::..:|  |||::.|.|            |.||      ..:..|||
Zfish   181 KRVRKKKKMFMESED--EEEENIE--EEEERVKSSKGRRAAKVARLVTAPL------VKKKTWSW 235

Human    55 EWYLKEQKAVAAPVELFSKDQSFPEHENGFQIGMRLEGIDPRHPSVFCVLSVAEVCGYRLRLHFD 119
            ..||:|::|.|||::||.:.||||:..|||::||:|||:||.||::||||:||||.|||:|||||
Zfish   236 SVYLEEERAAAAPLKLFKEHQSFPQSRNGFKVGMKLEGLDPCHPALFCVLTVAEVQGYRIRLHFD 300

Human   120 GYLSCYDFWTNAGSPDIHPVGWCEKTKHELHIPKGYRKDKFVWMDYLKACKLQNAPKKLFRNR-- 182
            ||..|||||.||.|.|:.|.||||||..:|.:|||.|..:|.|..|:|.|:.|.|||.||::.
Zfish   301 GYPECYDFWVNADSWDVKPPGWCEKTSLKLLLPKGCRDGEFNWNTYVKNCRGQLAPKHLFKSLNT 365

Human   183 --SPNGPMSKEFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYVQ 245
              :|:|     |:.|||||||||||.|.:||||||..|::|||:|.|:.||::|||||.:|||:.
Zfish   366 SVTPSG-----FRAGMKLEAVDRKNLSDICVATIAAAVDNRLLIHIDHCDDTHDYWCDASSPYIH 425

Human   246 PVGWCQENGRTLIAPQGYPNPENFSWTEYLEATQTNAVPAKVFKMRLPHGFLPNMKLEVVDKRNP 310
            |||:|:|...||..|..|.:.:.|||.:|||.|.|.|.||:.||.|.||||...:|||.||||||
Zfish   426 PVGYCEEVKLTLTTPAEYKHLKGFSWEKYLEETGTQAAPARAFKQRPPHGFQVGVKLEAVDKRNP 490

Human   311 RLIRVATIVDVDDQRVKVHFDGWDHKYDYWVEADSPDIHPIGWCDVTGHPLEVPQRTNDLKILPG 375
            .|||||||.|.::.|:|:|||||..:||||::||||::||:|||..|||||:.|..|.|..:.||
Zfish   491 MLIRVATISDTEEHRIKIHFDGWSDEYDYWLDADSPELHPVGWCQKTGHPLQHPNGTRDSPVPPG 555

Human   376 QAVCPTPGCRGIGHIRGPRYSGHHSAFGCPYSDMNLKKEATLHDRLREQTQANLESDSSHSKSKS 440
            |. ||||||.|:||||||||..|::|..|||||:|..|:..:.|||..:....:.....|.::::
Zfish   556 QG-CPTPGCNGVGHIRGPRYGTHYTAVSCPYSDLNFNKDGLVPDRLSGERPVTISGPPRHRRAET 619

Human   441 LCSLNFNGKHEKVNS---------------QPRLVQQ-------AKCLK---IKGKEDIDLDNLF 480
            |..     .|:..:|               |.|.|::       .||:|   :|.:.|
Zfish   620 LTQ-----THQPTSSASTPEPPDTTTDACPQARPVREHVVTAAAPKCVKAPQVKQEGD------- 672

Human   481 RVLVLHPRGLEYSVEQAQQVLHQSVSMSTVSAHPFRDLPLGREQHCKLLPGVADIRASQVARWTV 545
                        ..:..||.||:||........    ..|..|:|.||||....:.|.:|::|..
Zfish   673 ------------GKDSLQQFLHESVFCGWEQPR----FQLCWEKHGKLLPEALGLTAKRVSKWNT 721

Human   546 DEVAEFVQSLLGCEEHAKCFKKEE 569
            :|||.||:.|.||.|||..|:||:
Zfish   722 EEVASFVRGLPGCREHAPTFRKEQ 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
L3MBTL4	XP_011524059.1	MBT	57..149	CDD:214723	59/91 (65%)
		MBT	164..260	CDD:214723	53/99 (54%)
		MBT	273..364	CDD:214723	57/90 (63%)
		zf-C2HC	379..405	CDD:279824	17/25 (68%)
		SAM_superfamily	540..>569	CDD:301707	15/28 (54%)
l3mbtl1b	XP_009290632.1	MBT	238..333	CDD:214723	60/94 (64%)
		MBT	346..440	CDD:214723	53/98 (54%)
		MBT	452..544	CDD:214723	57/91 (63%)
		zf-C2HC	557..584	CDD:279824	17/27 (63%)
		SAM_Scm-like-3MBT3,4	716..781	CDD:188981	16/30 (53%)
		SAM	716..781	CDD:197735	16/30 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I25137
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG43823
OrthoDB	1	1.010	-	-		D40962at33208
OrthoFinder	1	1.000	-	-		FOG0002225
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104389
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1471
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.730