DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment L3MBTL4 and l(3)mbt

DIOPT Version :9

Sequence 1:	XP_011524059.1	Gene:	L3MBTL4 / 91133	HGNCID:	26677	Length:	651	Species:	Homo sapiens
Sequence 2:	NP_733209.1	Gene:	l(3)mbt / 43288	FlyBaseID:	FBgn0002441	Length:	1477	Species:	Drosophila melanogaster

Alignment Length:	722	Identity:	225/722 - (31%)
Similarity:	323/722 - (44%)	Gaps:	144/722 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     2 KQPNRKRKLNMDS-KERLDQDGRLEQAEEEKKPKDSTTPLSHVPSAAAQGAWSWEWYLKEQ-KAV 64
            :|.|.|...::.: :|:|.|    .|.::.:||                  :.|..|||.: |.|
  Fly   790 RQTNYKPHKSLSAIQEQLQQ----RQKDKPRKP------------------FRWSEYLKSKGKDV 832

Human    65 AAPVELFSKDQSFPEHENGFQIGMRLEGIDPRHPSVFCVLSVAEVCGYRLRLHFDGYLSCYDFWT 129
            |||:.||.  ..||...|.|:|||:||.|||.:.|:|||.|:.||.||||:|.||||.|.||||.
  Fly   833 AAPIHLFL--NPFPISPNCFEIGMKLEAIDPENCSLFCVCSIVEVRGYRLKLSFDGYSSMYDFWV 895

Human   130 NAGSPDIHPVGWCEKTKHELHIPKGYRKDKFVWMDYLKACKLQNAPKKLF--RNRSPNGPMSKEF 192
            ||.|.||.|.|||::|...|..||.|..::|.|..||.....:.||:.||  .|......:...|
  Fly   896 NADSQDIFPPGWCDETARVLQAPKDYNSERFSWSRYLVKTGGKAAPRALFGHLNMQQQMDVRNGF 960

Human   193 QVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYVQPVGWCQENGRTL 257
            .|||.|||.|..:...:||||:.||:::|:.||||.|||.||.|..:.|||:.|.|| .|..:.|
  Fly   961 AVGMHLEAEDLNDTGKICVATVTDILDERIRVHFDGWDDCYDLWVHITSPYIHPCGW-HEGRQQL 1024

Human   258 IAPQGYPNPENFSWTEYLEATQTNAVPAKVFKMRLPHGFLPNMKLEVVDKRNPRLIRVATIVDVD 322
            |.|..| ....|.|.:|:......|...::|..|.|..:...|||||||:|||.|||.||:|...
  Fly  1025 IVPPDY-QKSAFIWDDYISEVGGMAASKELFTPRQPMEYQERMKLEVVDQRNPCLIRPATVVTRK 1088

Human   323 DQRVKVHFDGWDHKYDYWVEADSPDIHPIGWCDVTGHPLEVPQRTNDLK-ILPGQAVCPTPGCRG 386
            ..||::|.|.|..:|.:|:|.||||:||||||:.|.|.||.|......| ::|    |...||||
  Fly  1089 GYRVQLHLDCWPTEYYFWLEDDSPDLHPIGWCEATSHELETPPGYLQPKSVMP----CDVEGCRG 1149

Human   387 IGHIRGPRYSGHHSAFGCPYSDMNLKKEATLHDRLREQTQANLESDSSHSKSKSLCS-----LNF 446
            .|:.:....:.|.....|||:..|.::..:...:.......|:....: .|:|..||     :..
  Fly  1150 FGNAKRFNLNVHALRECCPYAPENWRQWRSKTVKPPRVAPENIRRGWA-KKTKRACSEAKQAIKE 1213

Human   447 NGKHEKVNSQPRLVQQAK-----CLK--IKGKEDIDLDNLFRVLVLHPRGLEYSVEQAQQVLHQ- 503
            :.:.|.|..:...|.|||     |.:  :|.::.:..:                 |.|:||..:
  Fly  1214 DSQQEIVYPKVAEVVQAKRKTSPCEEKVVKKQKQMQKE-----------------EDAEQVPDER 1261

Human   504 --SVSMSTVSAHPFRDLPLGREQHCKLLPGVADIRASQVARWTVDEVAEFVQSLLGCEEHAKCF- 565
              :::.|.|..:..:.||..|.........:.|:|.:.: .||..:|.|:::..|...:.||..
  Fly  1262 SLAIARSFVKDYGPQFLPNYRLWQLNSAFKLDDVRTNPL-HWTSWDVCEYIERALDSTDIAKVIF 1325

Human   566 -------------KKE-------------------------------------ESSEPGCVNQRR 580
                         :||                                     ||:..|.: ||.
  Fly  1326 EQDIDGRALLMLGRKELDTYLKLKVGPAVKLYSLILNLRIAVVCKFDSKNIELESNTAGPI-QRE 1389

Human   581 CSSPWSC-------AEVTG--------ASRSWGKQPTRWPLPSSDRWQSLPAS--------DTDG 622
            ..:|.|.       ::..|        .|.|.........:..||.:.|:..|        |.||
  Fly  1390 MDTPVSAIKQLPEQSQTNGYKTDHDQELSESGDDDDDEDVMLDSDDFLSVKPSCLVIDEDADGDG 1454

Human   623 HCQSDED 629
            .|:||.|
  Fly  1455 DCESDGD 1461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
L3MBTL4	XP_011524059.1	MBT	57..149	CDD:214723	53/92 (58%)
		MBT	164..260	CDD:214723	41/97 (42%)
		MBT	273..364	CDD:214723	43/90 (48%)
		zf-C2HC	379..405	CDD:279824	7/25 (28%)
		SAM_superfamily	540..>569	CDD:301707	9/79 (11%)
l(3)mbt	NP_733209.1	MBT	822..918	CDD:214723	54/97 (56%)
		MBT	929..1028	CDD:214723	41/99 (41%)
		MBT	1038..1130	CDD:214723	43/91 (47%)
		SAM_PNT	1279..1366	CDD:280377	13/87 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149831
Domainoid	1	1.000	97	1.000	Domainoid score	I7260
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002225
OrthoInspector	1	1.000	-	-		otm41370
orthoMCL	1	0.900	-	-		OOG6_104389
Panther	1	1.100	-	-	LDO	PTHR12247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5341
SonicParanoid	1	1.000	-	-		X1471
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.870