Protein Alignment LATS1 and CBK1

DIOPT Version :10

• Sequence 1: XP_016866963.1
• Gene: LATS1 / 9113
• HGNCID: 6514
• Length: 1163
• Species: Homo sapiens
• Sequence 2: NP_014238.3
• Gene: CBK1 / 855561
• SGDID: S000005105
• Length: 756
• Species: Saccharomyces cerevisiae
• Alignment Length: 872
• Identity: 269/872 - (30%)
• Similarity: 404/872 - (46%)
• Gaps: 228/872 - (26%)

Human   310 MNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQN---------GTGQTDFMIHQNVVPA 365
            |||..|         :.|.|....||:..........:|.         |:|.||       |||
Yeast    39 MNPYQQ---------IPRPPAAGFSSNYMKEQGSHQSLQEHLQRETGNLGSGFTD-------VPA 87

Human   366 GTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPG-- 428
            ......|||.....|:|    ..:.|...:....|.:.:..|||:.....|.|.:|..:| ||
Yeast    88 LNYPATPPPHNNYAASN----QMINTPPPSMGGLYRHNNNSQSMVQNGNGSGNAQLPQLS-PGQY 147

Human   429 -LQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSN-SFNNPLGNRASHSANSQPSATTVTAITP 491
             :::.:.|:.:..:.|||.  |:..|      :||| |:::.|
Yeast   148 SIESEYNQNLNGSSSSSPF--HQPQT------LRSNGSYSSGL---------------------- 182

Human   492 APIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPP 556
                :.|||.:.|:.|.:                             ||.|...:::|.
Yeast   183 ----RSVKSFQRLQQEQE-----------------------------NVQVQQQLSQAQ------ 208

Human   557 PPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYE------NVDSGDKEKKQITTSPI 615
                    .||            |::.|..|..:.:.::..:      ......::::|.:.||:
Yeast   209 --------QQN------------SRQQQQQLQYQQQQQQQQQQQHMQIQQQQQQQQQQQQSQSPV 253

Human   616 -------TVRKNKKDEERRESRIQSYSPQ---AFKFFMEQHVENVLKSHQQRLHRKKQLENEMMR 670
                   |: .|....|||...:...:..   |.|..:|...::.:|...:|..|:.:||.|:..
Yeast   254 QSGFNNGTI-SNYMYFERRPDLLTKGTQDKAAAVKLKIENFYQSSVKYAIERNERRVELETELTS 317

Human   671 VGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKT 735
            ...|::.:.:....|.:|||.::||:|.::....|..:|.:|.||||||.|.:|.||..:||.||
Yeast   318 HNWSEERKSRQLSSLGKKESQFLRLRRTRLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKT 382

Human   736 LRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIF 800
            |.|.::..::|:||||||||:||.:|:.|||.|||||||...||.:|:::||||:|::|||..:|
Yeast   383 LLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLF 447

Human   801 PESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQS- 864
            .|.:.|||:||...|:|::||:|||||||||||||||..|||||:||||.|||..||||.||:.
Yeast   448 TEDVTRFYMAECILAIETIHKLGFIHRDIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKL 512

Human   865 -------------GDHPRQDSMDFSNEWG----DPSSCRCGDRLKPLERRAARQHQRCLAHSLVG 912
                         |.: ..::.|.:|:..    |..|....:|   .:.:..|:.:|.:|:|.||
Yeast   513 LQQDEATNGISKPGTY-NANTTDTANKRQTMVVDSISLTMSNR---QQIQTWRKSRRLMAYSTVG 573

Human   913 TPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKPGMVAHTCNPSALEGH 977
            ||:|||||:.|..||.|.|||||:|.|::|.|:|.|||.::||.||..|
Yeast   574 TPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRK---------------- 622

Human   978 SRKNTGTQEFEIGLGNIVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKN-GADEIKAHP 1041
                             ::|::.:|..|....:|.||.|||.:|....:.|||:: ||||||:||
Yeast   623 -----------------IMNFEQTLQFPDDIHISYEAEDLIRRLLTHADQRLGRHGGADEIKSHP 670

Human  1042 FFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVND-------------- 1092
            ||:.:|::: :||..|.||||::..||| .|.|.|         |.|||.|
Yeast   671 FFRGVDWNT-IRQVEAPYIPKLSSITDT-RFFPTD---------ELENVPDSPAMAQAAKQREQM 724

Human  1093 TLNGWYKNGKHP---EHAFYEFTFRRF 1116
            |..|    |..|   :..|..:|:.||
Yeast   725 TKQG----GSAPVKEDLPFIGYTYSRF 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LATS1	XP_016866963.1	UBA_LATS1	103..143	CDD:270580
		PRK10263	<448..>596	CDD:236669	21/148 (14%)
		MobB_LATS1	629..704	CDD:439273	17/77 (22%)
		Protein Kinases, catalytic domain	703..1117	CDD:473864	187/450 (42%)
CBK1	NP_014238.3	MobB_CBK1	269..341	CDD:439268	17/71 (24%)
		STKc_NDR_like_fungal	350..748	CDD:270778	187/450 (42%)