Protein Alignment LATS1 and lats1

DIOPT Version :10

• Sequence 1: XP_016866963.1
• Gene: LATS1 / 9113
• HGNCID: 6514
• Length: 1163
• Species: Homo sapiens
• Sequence 2: NP_001018346.1
• Gene: lats1 / 553164
• ZFINID: ZDB-GENE-050523-2
• Length: 1068
• Species: Danio rerio
• Alignment Length: 1183
• Identity: 717/1183 - (60%)
• Similarity: 843/1183 - (71%)
• Gaps: 135/1183 - (11%)

Human     1 MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTEDPRQV 65
            |:|:||||||||||||||||||.:.:|:||||||||||||||..|:|:|.|.:..|...::.||.
Zfish     1 MRRAEKPEGYRQMRPKTFPASNNSGNSQQMLQEIRESLRNLSPSSNASKPEQSSGKGPPDESRQQ 65

Human    66 --RNPPKFGTHHKALQEIRNSLLPFANETNSS--RSTSEVNPQMLQDLQAAGFDEDMVIQALQKT 126
              ...|:...||:||||||.||.|||::::||  .|:::.:...|| .|..||||:::
Zfish    66 GRSTNPRNSHHHRALQEIRKSLQPFAHDSSSSGDNSSADSSKHTLQ-TQEPGFDEELM------- 122

Human   127 NNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMK---PGNVQQSVNRKQSWKGSKESLVPQ 188
                       ::::::|:..|||:  .:|||:|.::|   |..:||.:.|:||||||||||.||
Zfish   123 -----------VNRINFQEAVREQI--PSARPVNTAIKQAGPPQIQQPLLRRQSWKGSKESLAPQ 174

Human   189 RHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQ--AHPSNGQRVNPPPPPQVRSVTPPPPP 251
            ||...:.:.:.|...||..|:|:.||      :.|.|  |..|:|||||.|...||||:
Zfish   175 RHSALINDVLIYRPSSPGPQSDLSRP------ATFPQNLASASSGQRVNAPLSRQVRSI------ 227

Human   252 RGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQG 316
                      ||||.||:.|..|||||||::|::.||||||.|...:||         :||.:|.
Zfish   228 ----------TPPPSSWDSNPSTKRYSGNLDYLVPRISPVPQGPRGDGY---------INPQSQN 273

Human   317 QRGISSVPVGRQPIIMQ--SSSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLT 379
            |||:..|||||||||||  :|:|||||...|  |||:.|.::|    .:.:| ..:.|||||.:.
Zfish   274 QRGLRPVPVGRQPIIMQNSNSNKFNFPPSWP--QNGSMQNEYM----GMNSG-ARQPPPPPYSMH 331

Human   380 AANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISV--PGLQTNWPQSSSAPAQ 442
            ..|.|||:|.|...||..:.....|:||||:||||||||:::||:.|  |.:|    |:.:.|.|
Zfish   332 QTNRQSPTAQQMQSSALTAPPNGASLPQSMLVPNRNSHNLDMYNLGVIRPPVQ----QAQTPPGQ 392

Human   443 SSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPE 507
            .:.||      |..::|.|||||.:...|| ....|||.||||||.:|.|||.||||||||.|||
Zfish   393 DTSSS------WTHSVPGRSNSFTSAPNNR-RQCPNSQLSATTVTTVTQAPILQPVKSMRVQKPE 450

Human   508 LQTALAPTHPSWI-PQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQNPSVP 571
            |.||:||.||.|: |.|....|..|.|..         |.||.|:|||||||||||||.|....|
Zfish   451 LHTAVAPAHPPWLQPPPPTAYQEPPTPPA---------PAAEVPSYQGPPPPYPKHLLQQQQPPP 506

Human   572 PYES--ISKPSKEDQPSLPKEDESEK--SYENVDSGDKEKKQITTSPITVRKNKKDEERR-ESRI 631
            .|:|  ..||..::..:...|::::.  |.|..:..::|||||||||:.||::|:||||: |||:
Zfish   507 GYDSSPALKPCSKEGDAADNENDTDSTCSSERAEGSEEEKKQITTSPVPVRRHKRDEERKGESRL 571

Human   632 QSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLK 696
            ..||||||||||||||||:||:||||:.||||||:||.|||||.|||:|||.||.||||||||||
Zfish   572 PMYSPQAFKFFMEQHVENILKNHQQRMRRKKQLESEMQRVGLSGDAQEQMRMMLSQKESNYIRLK 636

Human   697 RAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEAD 761
            ||||||.||.|||||||||||||||||||||.||||.||||||||||||||||||||||||||||
Zfish   637 RAKMDKCMFEKIKTLGIGAFGEVCLARKVDTGALYAMKTLRKKDVLLRNQVAHVKAERDILAEAD 701

Human   762 NEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIH 826
            |||||||||||||||||||||||||||||||||||||||.|.||:||||||.|||||||||||||
Zfish   702 NEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFQEDLAQFYIAELICAVESVHKMGFIH 766

Human   827 RDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRL 891
            |||||||||||||||||||||||||||||||||||||||||.||||||||.||.|.::|||||||
Zfish   767 RDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHVRQDSMDFSMEWEDSANCRCGDRL 831

Human   892 KPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPL 956
            |||||||||||||||||||||||||||||||||||||||||||||||||:||:||||||||.|||
Zfish   832 KPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILYEMVVGQPPFLATTPL 896

Human   957 ETQMKPGMVAHTCNPSALEGHSRKNTGTQEFEIGLGNIVINWQTSLHIPPQAKLSPEASDLIIKL 1021
            |||||                                 ||.||||||||.||||||||:|||:||
Zfish   897 ETQMK---------------------------------VIRWQTSLHIPLQAKLSPEATDLILKL 928

Human  1022 CRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQ-SASYIPKITHPTDTSNFDPVDPDKLWSDDN 1085
            ||||:||||:||||||||.|||:|||.|.||||| .|.|||||||.||||||||||||||||:|
Zfish   929 CRGPDDRLGRNGADEIKAQPFFRTIDLSKDLRQQHQAPYIPKITHSTDTSNFDPVDPDKLWSED- 992

Human  1086 EEENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQN 1150
            .:.|.||||..|:|||||||||||||||||||||:|:||:.|||||.|  .....|...:||:.:
Zfish   993 ADGNHNDTLTRWFKNGKHPEHAFYEFTFRRFFDDSGHPYSCPKPIESE--EEDEDEDYVEEDEPS 1055

Human  1151 TGSEIKNRDLVYV 1163
            .....::||||||
Zfish  1056 QRPMEQSRDLVYV 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LATS1	XP_016866963.1	UBA_LATS1	103..143	CDD:270580	7/39 (18%)
		PRK10263	<448..>596	CDD:236669	70/152 (46%)
		MobB_LATS1	629..704	CDD:439273	61/74 (82%)
		Protein Kinases, catalytic domain	703..1117	CDD:473864	341/414 (82%)
lats1	NP_001018346.1	PHA03247	<137..516	CDD:223021	201/436 (46%)
		MobB_LATS1	569..644	CDD:439273	61/74 (82%)
		Protein Kinases, catalytic domain	644..1024	CDD:473864	341/413 (83%)