Protein Alignment LATS1 and trc

DIOPT Version :10

• Sequence 1: XP_016866963.1
• Gene: LATS1 / 9113
• HGNCID: 6514
• Length: 1163
• Species: Homo sapiens
• Sequence 2: NP_001262071.1
• Gene: trc / 40165
• FlyBaseID: FBgn0003744
• Length: 463
• Species: Drosophila melanogaster
• Alignment Length: 482
• Identity: 189/482 - (39%)
• Similarity: 281/482 - (58%)
• Gaps: 57/482 - (11%)

Human   640 KFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSM 704
            |..:|.:..|::..:.:|..|..:||.::....||:..:.:.|....|||:.|:||||.::....
  Fly    28 KVTLENYYSNLVTQYGERKQRLAKLEAQLKDESLSEAQRQEKRLQHAQKETEYLRLKRLRLGVED 92

Human   705 FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLY 769
            |..:|.:|.||||||.|.:|.||..:||.|.|||.|:|.:.|||||:||||:|.|||::|||::|
  Fly    93 FEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEADHQWVVKMY 157

Human   770 YSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNI 834
            |||||..|||.:|:::||||||:||::.....|...:|||:|...|::|:||:|||||||||||:
  Fly   158 YSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIHRDIKPDNL 222

Human   835 LIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLE--RR 897
            |:|..||:||:|||||||.:.:|.:.:|:  |..:....||.   |..:|..|    .|::  ||
  Fly   223 LLDARGHLKLSDFGLCTGLKKSHRTDFYR--DLSQAKPSDFI---GTCASLSC----SPMDSKRR 278

Human   898 AA--RQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQM 960
            |.  ::::|.||:|.||||:||||||.|:|||...|||||:|||::|||:|.|||.:..|.:|..
  Fly   279 AESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTYR 343

Human   961 KPGMVAHTCNPSALEGHSRKNTGTQEFEIGLGNIVINWQTSLHIPPQAKLSPEASDLIIKLCRGP 1025
            |                                 |:||:.:|..||:..:|.||.:.||..|...
  Fly   344 K---------------------------------VMNWRETLIFPPEIPISEEAKETIINFCCEA 375

Human  1026 EDRLG-KNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEEN 1089
            :.||| :.|.:::|:.|||:.:|: ..:|::.|:...::....||||||......|.........
  Fly   376 DRRLGSQRGLEDLKSVPFFRGVDW-EHIRERPAAIPVEVRSIDDTSNFDEFPDVSLEIPSAPIPQ 439

Human  1090 VNDTLNGWYKNGKHPEHAFYEFTFRRF 1116
            ..:....|         .|..:|::||
  Fly   440 GGEIAKDW---------VFINYTYKRF 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LATS1	XP_016866963.1	UBA_LATS1	103..143	CDD:270580
		PRK10263	<448..>596	CDD:236669
		MobB_LATS1	629..704	CDD:439273	18/63 (29%)
		Protein Kinases, catalytic domain	703..1117	CDD:473864	171/419 (41%)
trc	NP_001262071.1	MobB_Trc-like	24..88	CDD:439274	18/59 (31%)
		STKc_NDR_like	91..455	CDD:270750	169/415 (41%)