DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LATS1 and ppk18

DIOPT Version :9

Sequence 1:	XP_016866963.1	Gene:	LATS1 / 9113	HGNCID:	6514	Length:	1163	Species:	Homo sapiens
Sequence 2:	NP_001018270.2	Gene:	ppk18 / 3361535	PomBaseID:	SPAPB18E9.02c	Length:	1318	Species:	Schizosaccharomyces pombe

Alignment Length:	925	Identity:	236/925 - (25%)
Similarity:	345/925 - (37%)	Gaps:	319/925 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   424 ISVPGLQTNWPQS--SSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQ------ 480
            :.|| |....|.|  |||.:.|..|...:|          .|..:|.|.:..|::.:..
pombe   247 LGVP-LAAVLPSSITSSAKSNSRSSLSQKI----------RNYISNMLFDAISYTDSCLAIHLPF 300

Human   481 -PSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSW------------------------- 519
             |.:||      ....||...:|:|.|..:...|.| .||
pombe   301 IPESTT------REDNQPFSEIRLLSPASEVFNAKT-LSWCLPHIDDPGLQLMFENTDALVKKKL 358

Human   520 -------------------IPQPIQT-----VQPSPFPEGTASNV-TVMPPVAEAPNYQGPPPPY 559
                               |...:||     :|...:.|..::.. |::.|:.|.
pombe   359 DAINRLSNIIYYSERVRCEIEDQVQTIIEQSIQVDGYDEPLSTTTPTLIEPIQET---------- 413

Human   560 PKHLLHQNPSV--PPYESISKPS--------------KEDQPSLPKEDESEKSYENVDSGDKEKK 608
               |:.|:|.:  .|:.:: |||              :.|.|......:|..|:....|......
pombe   414 ---LMTQSPIIECEPFNTV-KPSVSPEEVHDISQFNHRNDPPITAASVDSSNSFSVHRSSTNHSS 474

Human   609 QITTSPITVRKNK---KDEERRESRI---------QSYSPQAFKFF-----MEQHVENVLKSHQQ 656
            ..:.||...|:|.   ....||:|..         .||:.::|.|.     :|::.....:|.:.
pombe   475 TNSGSPNLSRRNNLAIPIASRRKSVSAVNTLYGVGSSYTSESFPFSKLTVPVERNSFRETESPKP 539

Human   657 RLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSM--FVKIKTLGIGAFGEV 719
            .|.|         ::|:|            ...||   :...|...|:  :..||.:..|.||.|
pombe   540 FLSR---------QIGIS------------TLSSN---ISSGKGTPSIQDYEIIKPISKGTFGTV 580

Human   720 CLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDIL-AEADNEWVVRLYYSFQDKDNLYFVMD 783
            .|:||..|..:||.|.|||.|::.:||||:|||||.:| |:.::.:|.:|||:||.:|.||.||:
pombe   581 YLSRKNTTGEIYAIKVLRKVDMISKNQVANVKAERAVLMAQEESAFVAKLYYAFQSRDYLYLVME 645

Human   784 YIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFG 848
            ::.|||..|||..:...|||.|:.||||:...:|.:|::|.|||||||||||:...||:||.|||
pombe   646 FMNGGDCASLLKSLYTIPESWAKIYIAEVALGLEHLHRLGIIHRDIKPDNILMSITGHLKLADFG 710

Human   849 LCTGFRWTHDSKYYQSGDHPRQ-------------DSMDFSNEWGDPSSCRCGDRL--KPL---- 894
            |.            |.|...||             .|.......|||     ||.:  .||
pombe   711 LS------------QLGLTTRQLRLQKGKNNILSPPSFQSPTALGDP-----GDNIASSPLILPT 758

Human   895 -------ERRAARQ--------------------------------------------------- 901
                   :.::.:|
pombe   759 SVSAFSYDEKSQKQKTELATFTTYKEDDTTTTTRTSIDSISSKYLESPVDSQKVNRTPNLQSVPF 823

Human   902 -HQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKPGMV 965
             .|.......||||:|:|||.|..:....:.|||::|.:|||.|.|.|||.|:||
pombe   824 FRQPDAPKRFVGTPDYLAPETLRGSTQDDMVDWWALGCVLFEFLFGYPPFHAETP---------- 878

Human   966 AHTCNPSALEGHSRKNTGTQEFEIGLGNIVIN---WQTSLHIPPQAKLSP---EASDLIIKLCR- 1023
                              .:.||    ||:.|   |       |..::.|   ||.|||....:
pombe   879 ------------------EKVFE----NILANNIAW-------PDLEMYPCSEEALDLINGFLQP 914

Human  1024 GPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFD-------------PV 1075
            .||.|||.:..:|||.||||..|:: .|:....|.:||....|.||:.||             .|
pombe   915 NPERRLGFSDINEIKEHPFFNGINW-DDIFSHEAPFIPAPETPLDTAYFDSRGAGAAESNMSSSV 978

Human  1076 DPDKLWSDDNEEENVNDTLNGWY---KNGKHPEHAFYEFTFRRF------FDDNGYPYNYPKPIE 1131
            :..:..|.||   ||:......:   .:|:..|.:......|||      ||:.| |::|.....
pombe   979 NSGEEVSKDN---NVSQERGSQFLRSSHGRSRERSTSARRSRRFSEANSEFDEFG-PFSYKNLSV 1039

Human  1132 YEYINSQGSEQQSDE 1146
            .|..|....|:...|
pombe  1040 LERANRNAIEKIRSE 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LATS1	XP_016866963.1	UBA_LATS1	103..143	CDD:270580
		FtsK	<448..>596	CDD:332908	35/220 (16%)
		PKc_like	703..1117	CDD:328722	160/523 (31%)
ppk18	NP_001018270.2	S_TKc	566..934	CDD:214567	136/423 (32%)
ppk18	NP_001018270.2	PKc_like	569..940	CDD:304357	139/427 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910