Protein Alignment LATS1 and Lats1

DIOPT Version :10

• Sequence 1: XP_016866963.1
• Gene: LATS1 / 9113
• HGNCID: 6514
• Length: 1163
• Species: Homo sapiens
• Sequence 2: NP_001128015.2
• Gene: Lats1 / 308265
• RGDID: 1564085
• Length: 1130
• Species: Rattus norvegicus
• Alignment Length: 1163
• Identity: 1057/1163 - (90%)
• Similarity: 1096/1163 - (94%)
• Gaps: 33/1163 - (2%)

Human     1 MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTEDPRQV 65
            |||.|||||||||||||||||||:.||||||||||||||||||||||||||||::||||||||||
  Rat     1 MKRGEKPEGYRQMRPKTFPASNYSGSSRQMLQEIRESLRNLSKPSDAAKAEHNLNKMSTEDPRQV 65

Human    66 RNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVIQALQKTNNRS 130
            |||||||||||||||||||||||||||:|||..|||||||.||||||||||||||||||||||||
  Rat    66 RNPPKFGTHHKALQEIRNSLLPFANETSSSRIPSEVNPQMFQDLQAAGFDEDMVIQALQKTNNRS 130

Human   131 IEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLG 195
            ||||:||||||||||||||||||||||||||:|||||||.|::|||||||||||||||||||.||
  Rat   131 IEAAVEFISKMSYQDPRREQMAAAAARPINATMKPGNVQHSISRKQSWKGSKESLVPQRHGPSLG 195

Human   196 ESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRG 260
            |:|.|.|||||||.|||||||||||:||.||||||||||||||||||||||||||||||||||||
  Rat   196 ENVVYRSESPNSQADVGRPLSGSGITAFAQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRG 260

Human   261 TTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPV 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 TTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPV 325

Human   326 GRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQ 390
            |||||||||:|||||..||||:|||.|||||::||||||.|.||||||||||||.||||||||||
  Rat   326 GRQPIIMQSTSKFNFTPGRPGVQNGGGQTDFIMHQNVVPTGAVNRQPPPPYPLTPANGQSPSALQ 390

Human   391 TGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQ 455
            .||.|||.|::||::|.:||||||||||||||||:||||||.||||||||.||||||||||||||
  Rat   391 AGGPAAPPSFSNGNVPPTMMVPNRNSHNMELYNINVPGLQTTWPQSSSAPVQSSPSSGHEIPTWQ 455

Human   456 PNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWI 520
            |||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||:
  Rat   456 PNIPVRSNSFNNPLGSRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWM 520

Human   521 PQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQP 585
            |||:||||||||.||.||||.|:|||||||:|||||||||||||||.||||||||.|||.|:|||
  Rat   521 PQPVQTVQPSPFSEGAASNVPVIPPVAEAPSYQGPPPPYPKHLLHQTPSVPPYESASKPCKDDQP 585

Human   586 SLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENV 650
            |..||::||||.::|||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   586 SSAKEEDSEKSLDSVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENV 650

Human   651 LKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGA 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   651 LKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGA 715

Human   716 FGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYF 780
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   716 FGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYF 780

Human   781 VMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLT 845
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
  Rat   781 VMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLT 845

Human   846 DFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSL 910
            |||||||||||||||||||||||||||||||:||||||:||||||||||||||||||||||||||
  Rat   846 DFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSSEWGDPSNCRCGDRLKPLERRAARQHQRCLAHSL 910

Human   911 VGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKPGMVAHTCNPSALE 975
            |||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   911 VGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMK-------------- 961

Human   976 GHSRKNTGTQEFEIGLGNIVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAH 1040
                               ||||||||||||||||||||||||||||||||||||||||||||||
  Rat   962 -------------------VINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAH 1007

Human  1041 PFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPE 1105
            |||||||||||||||||||||||||||||||||||||||||||.|||||:|||||||||||||||
  Rat  1008 PFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDGNEEENINDTLNGWYKNGKHPE 1072

Human  1106 HAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV 1163
            |||||||||||||||||||||||||||||::|||||||||||||:|||::.|||||||
  Rat  1073 HAFYEFTFRRFFDDNGYPYNYPKPIEYEYVSSQGSEQQSDEDDQHTGSDVNNRDLVYV 1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LATS1	XP_016866963.1	UBA_LATS1	103..143	CDD:270580	37/39 (95%)
		PRK10263	<448..>596	CDD:236669	131/147 (89%)
		MobB_LATS1	629..704	CDD:439273	74/74 (100%)
		Protein Kinases, catalytic domain	703..1117	CDD:473864	375/413 (91%)
Lats1	NP_001128015.2	UBA_like_SF	103..143	CDD:473871	37/39 (95%)
		PHA03247	<183..590	CDD:223021	363/406 (89%)
		MobB_LATS1	629..704	CDD:439273	74/74 (100%)
		STKc_LATS1	703..1084	CDD:270775	375/413 (91%)