DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LATS1 and Lats1

DIOPT Version :9

Sequence 1:	XP_016866963.1	Gene:	LATS1 / 9113	HGNCID:	6514	Length:	1163	Species:	Homo sapiens
Sequence 2:	NP_034820.1	Gene:	Lats1 / 16798	MGIID:	1333883	Length:	1129	Species:	Mus musculus

Alignment Length:	1163	Identity:	1052/1163 - (90%)
Similarity:	1095/1163 - (94%)	Gaps:	34/1163 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTEDPRQV 65
            |||.|||||||||||||||||||..||||||||||||||||||||||:|||||::||||||||||
Mouse     1 MKRGEKPEGYRQMRPKTFPASNYPGSSRQMLQEIRESLRNLSKPSDASKAEHNLNKMSTEDPRQV 65

Human    66 RNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVIQALQKTNNRS 130
            |||||||||||||||||||||||||||:||||.|||||||.||||||||||||||||||||||||
Mouse    66 RNPPKFGTHHKALQEIRNSLLPFANETSSSRSPSEVNPQMFQDLQAAGFDEDMVIQALQKTNNRS 130

Human   131 IEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLG 195
            ||||:||||||||||||||||:|||||||||:|||||||.|:||||||||||||||||||||.||
Mouse   131 IEAAVEFISKMSYQDPRREQMSAAAARPINATMKPGNVQHSINRKQSWKGSKESLVPQRHGPSLG 195

Human   196 ESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRG 260
            |:|.|.|||||||.|||||||||||:||.||||||||||||||||||||||||||||||||||||
Mouse   196 ENVVYRSESPNSQADVGRPLSGSGIAAFAQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRG 260

Human   261 TTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPV 325
            ||||||||||:||||||||||||||||||||||||||||||||||.|||||||:|.||.||||||
Mouse   261 TTPPPPSWEPSSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLTTSPMNPPSQAQRAISSVPV 325

Human   326 GRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQ 390
            |||||||||:|||||..||||:|||.||:||::||| ||.|:|.||||||||||.||||||||||
Mouse   326 GRQPIIMQSTSKFNFTPGRPGVQNGGGQSDFIVHQN-VPTGSVTRQPPPPYPLTPANGQSPSALQ 389

Human   391 TGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQ 455
            ||.||||.|:.||::|||||||||||||||||||:||||||.||||||||||||||.||||||||
Mouse   390 TGASAAPPSFANGNVPQSMMVPNRNSHNMELYNINVPGLQTAWPQSSSAPAQSSPSGGHEIPTWQ 454

Human   456 PNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWI 520
            |||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||:
Mouse   455 PNIPVRSNSFNNPLGSRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWM 519

Human   521 PQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQP 585
            |||:|||||:||.|||||:|.|:|||||||:||||||||||||||||||||||||:|||.|::||
Mouse   520 PQPVQTVQPTPFSEGTASSVPVIPPVAEAPSYQGPPPPYPKHLLHQNPSVPPYESVSKPCKDEQP 584

Human   586 SLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENV 650
            ||||||:||||.::.||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   585 SLPKEDDSEKSADSGDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENV 649

Human   651 LKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGA 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   650 LKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGA 714

Human   716 FGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYF 780
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   715 FGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYF 779

Human   781 VMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLT 845
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Mouse   780 VMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLT 844

Human   846 DFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSL 910
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
Mouse   845 DFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSNCRCGDRLKPLERRAARQHQRCLAHSL 909

Human   911 VGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKPGMVAHTCNPSALE 975
            |||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   910 VGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMK-------------- 960

Human   976 GHSRKNTGTQEFEIGLGNIVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAH 1040
                               ||||||||||||||||||||||||||||||||||||||||||||||
Mouse   961 -------------------VINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAH 1006

Human  1041 PFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPE 1105
            |||||||||||||||||||||||||||||||||||||||||||.:||||::||||||||||||||
Mouse  1007 PFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDGSEEENISDTLNGWYKNGKHPE 1071

Human  1106 HAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV 1163
            ||||||||||||||||||||||||||||||:|||||||||||||:|.|:..|||||||
Mouse  1072 HAFYEFTFRRFFDDNGYPYNYPKPIEYEYIHSQGSEQQSDEDDQHTSSDGNNRDLVYV 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LATS1	XP_016866963.1	UBA_LATS1	103..143	CDD:270580	37/39 (95%)
		FtsK	<448..>596	CDD:332908	133/147 (90%)
		PKc_like	703..1117	CDD:328722	374/413 (91%)
Lats1	NP_034820.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		63/69 (91%)
		UBA_like_SF	103..143	CDD:304366	37/39 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..216		58/67 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..276		46/47 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..317		22/24 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..407		33/43 (77%)
		PPxY motif 1	372..375		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	432..492		57/59 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..630		99/116 (85%)
		Interaction with YAP1. /evidence=ECO:0000250	525..654		113/128 (88%)
		PPxY motif 2	555..558		2/2 (100%)
		STKc_LATS1	702..1083	CDD:270775	374/413 (91%)
		S_TKc	704..1009	CDD:214567	302/337 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1104..1129		19/24 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83952361
Domainoid	1	1.000	1070	1.000	Domainoid score	I1431
eggNOG	1	0.900	-	-		E1_KOG0608
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55843
Inparanoid	1	1.050	2188	1.000	Inparanoid score	I1292
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40066
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	1	1.000	-	-		oto119975
orthoMCL	1	0.900	-	-		OOG6_105652
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4821
SonicParanoid	1	1.000	-	-		X2473
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.300