Protein Alignment LATS1 and lats1

DIOPT Version :10

• Sequence 1: XP_016866963.1
• Gene: LATS1 / 9113
• HGNCID: 6514
• Length: 1163
• Species: Homo sapiens
• Sequence 2: XP_017949762.1
• Gene: lats1 / 100145677
• XenbaseID: XB-GENE-959763
• Length: 1117
• Species: Xenopus tropicalis
• Alignment Length: 1177
• Identity: 847/1177 - (71%)
• Similarity: 954/1177 - (81%)
• Gaps: 74/1177 - (6%)

Human     1 MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTEDPRQV 65
            |||.||||||||||||||||||||.||||||.|||||||:|.||||.||.|...:|  .||.||.
 Frog     1 MKRGEKPEGYRQMRPKTFPASNYTGSSRQMLLEIRESLRHLPKPSDVAKNEQLSAK--AEDSRQG 63

Human    66 RNPPKFGTHHKALQEIRNSLLPFANETNSS-RSTSEVNPQMLQDLQAAGFDEDMVIQALQKTNNR 129
            |:..||||:||||.|||||||||||.:.|| |..||:|.||..|||.|||||||||:|||:||:|
 Frog    64 RSTTKFGTYHKALAEIRNSLLPFANVSGSSPRGNSEINRQMFHDLQQAGFDEDMVIRALQQTNSR 128

Human   130 SIEAAIEFISKMSYQDPRREQMAAAAARPINASMK-PGNVQQSVNRKQSWKGSKESLVPQRHGPP 193
            |||||||:||:|:|  |...|....|||.:|||:| |||:|..|||:||||||||||:|||...|
 Frog   129 SIEAAIEYISRMNY--PEMYQEPHIAARTLNASIKPPGNMQNPVNRRQSWKGSKESLIPQRLVSP 191

Human   194 LGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPPQVRSVT-PPPPPRGQTPP 257
            |.::|.|.||:.:|||::||||||||:|||.||.|.||||||||||||:|||| |||||||||||
 Frog   192 LSDNVVYASENSSSQTEMGRPLSGSGLSAFAQALPVNGQRVNPPPPPQMRSVTPPPPPPRGQTPP 256

Human   258 PRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISS 322
            |:||||||.||||  |.||||||||::|.|::.:|.|:.|||:|     .|.:|..:||||.|:|
 Frog   257 PKGTTPPPTSWEP--QPKRYSGNMEFLIPRMNSIPSGSRQEGFP-----VSSVNTQSQGQRAINS 314

Human   323 VPVGRQPIIMQSS--SKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTV-NRQPPPPYPLTAANGQ 384
            |||||||||||:|  |||.: |||.|||||.|.::|:.:|.   .|.: .|||||||.:  .||.
 Frog   315 VPVGRQPIIMQTSNNSKFAY-SGRSGMQNGNGSSEFITNQG---GGNIGGRQPPPPYSI--PNGP 373

Human   385 SPSALQ----TGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSP 445
            :.:.||    :||..:.::|.|.::|.||:|.||||||:|:||||:||..|:|||:||  .||:|
 Frog   374 NTTTLQVQSGSGGPLSSNAYNNSNVPPSMLVSNRNSHNLEMYNISLPGHPTSWPQASS--TQSAP 436

Human   446 SSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQT 510
            .|.|::.:||.||||||||||||:.:..:.|.|:|.|||||||:||:||||||||:|||||||||
 Frog   437 GSNHDMLSWQTNIPVRSNSFNNPVASWQALSTNTQTSATTVTAVTPSPIQQPVKSIRVLKPELQT 501

Human   511 ALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYES 575
            |||||||:|:   ...|||.||.||.:.|.:..  :||||||||||||||||||.||.:|  ||.
 Frog   502 ALAPTHPTWM---TPNVQPGPFQEGVSHNTSAQ--LAEAPNYQGPPPPYPKHLLQQNTTV--YEP 559

Human   576 ISKPSKEDQP--SLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQA 638
            ..|.||||..  |...::|.||:.|.. :|..|||||||||:.||:||:|||||||:||||||||
 Frog   560 GLKSSKEDAAGVSTCTQEEMEKNTEPT-TGITEKKQITTSPVPVRRNKRDEERRESQIQSYSPQA 623

Human   639 FKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKS 703
            |||||||||||:||||.||||||||||||||||||||:||||||||||||||||||||||||:||
 Frog   624 FKFFMEQHVENILKSHHQRLHRKKQLENEMMRVGLSQEAQDQMRKMLCQKESNYIRLKRAKMEKS 688

Human   704 MFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRL 768
            |||||||||||||||||||||.||.||||.|||||||||||||||||||||||||||||||||||
 Frog   689 MFVKIKTLGIGAFGEVCLARKTDTNALYAMKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRL 753

Human   769 YYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDN 833
            ||||||||||||||||||||||||||||||:|||.|||||||||||||||||||.||||||||||
 Frog   754 YYSFQDKDNLYFVMDYIPGGDMMSLLIRMGVFPEDLARFYIAELTCAVESVHKMDFIHRDIKPDN 818

Human   834 ILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRA 898
            ||||||||||||||||||||||||||||||||||.||||||||||||||::|||||||||||.||
 Frog   819 ILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHLRQDSMDFSNEWGDPANCRCGDRLKPLEWRA 883

Human   899 ARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKPG 963
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||:|:|||||
 Frog   884 ARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILYEMLVGQPPFLAQSPVETQMK-- 946

Human   964 MVAHTCNPSALEGHSRKNTGTQEFEIGLGNIVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDR 1028
                                           ||.|||:||||.||||||||||||:|||||||||
 Frog   947 -------------------------------VIKWQTTLHIPAQAKLSPEASDLIVKLCRGPEDR 980

Human  1029 LGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDT 1093
            |||||.||||.|||||.||||||||||.|.|.|.|||||||||||||||:|||:|::::.|.|||
 Frog   981 LGKNGVDEIKVHPFFKNIDFSSDLRQQPAPYTPTITHPTDTSNFDPVDPEKLWNDEDKDGNKNDT 1045

Human  1094 LNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQ--GSEQQSDEDDQNTGSEIK 1156
            ||||||||||||||||||||||||||||:|||||||..|:|.::|  |.|....|:.:..|:...
 Frog  1046 LNGWYKNGKHPEHAFYEFTFRRFFDDNGHPYNYPKPFRYDYDDTQDMGGEDSDAEESEQDGNRPP 1110

Human  1157 NRDLVYV 1163
            |||||||
 Frog  1111 NRDLVYV 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LATS1	XP_016866963.1	UBA_LATS1	103..143	CDD:270580	30/39 (77%)
		PRK10263	<448..>596	CDD:236669	91/149 (61%)
		MobB_LATS1	629..704	CDD:439273	69/74 (93%)
		Protein Kinases, catalytic domain	703..1117	CDD:473864	348/413 (84%)
lats1	XP_017949762.1	UBA_LATS1	102..142	CDD:270580	30/39 (77%)
		MobB_LATS1	614..689	CDD:439273	69/74 (93%)
		STKc_LATS1	688..1069	CDD:270775	348/413 (84%)