Protein Alignment MTMR4 and mtm

DIOPT Version :10

• Sequence 1: NP_001364996.1
• Gene: MTMR4 / 9110
• HGNCID: 7452
• Length: 1209
• Species: Homo sapiens
• Sequence 2: NP_523489.1
• Gene: mtm / 33845
• FlyBaseID: FBgn0025742
• Length: 619
• Species: Drosophila melanogaster
• Alignment Length: 585
• Identity: 202/585 - (34%)
• Similarity: 296/585 - (50%)
• Gaps: 114/585 - (19%)

Human    47 PFTVLQGEGVE-----------FLGRAADALIAISNYRLHIK---FKDS----VINVPLRMIDSV 93
            ||..|:||..:           :.|....|| .|:||||:.:   .:|.    |::|||.:|..|
  Fly    46 PFGYLEGEEDQDQKNDVTYVCPYRGPVFGAL-TITNYRLYFRSLPLRDQEPPVVVDVPLGVIARV 109

Human    94 E--------SRDMFQLHISCKDSKVVRCHFSTFKQCQEWLSRLS-----RATARPAKPED-LFAF 144
            |        ..:.:.:.|.|||.:.:|     |...|:..||.:     :|.|.|..... ||||
  Fly   110 EKIGGATSRGENSYGIEIFCKDMRNLR-----FAHKQQNHSRRTVFEKLQANAFPLSYSGRLFAF 169

Human   145 AYHA------------WCLGLTEEDQHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHINSNY 197
            |:.|            |.           :.:|        .|||.|:|.. .::||.:.:|.:|
  Fly   170 AHAAANSVNGNGGWDGWA-----------VYEP--------LAELRRLGVP-NDMWRATKLNESY 214

Human   198 KLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADD 262
            .:|.|||....||...:|..|..||.|||..|:||:.:.:.|..|.|.|||||.:...|.||:||
  Fly   215 AICDSYPAVWAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDD 279

Human   263 EYLVTSIAKACALDPGTRATGGSLSTGNNDTSEACDADFDSSLTACSGVESTAAPQKLLILDARS 327
            |..::.|                                         :|:.|...||.|:|||.
  Fly   280 EAYLSFI-----------------------------------------MEANAQSDKLTIMDARP 303

Human   328 YTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKW 392
            ...|:||:|||||.|.|:.|.|.|:.|:.:.|||.:|.|.:.::..|....|.|.|.:|:::|.|
  Fly   304 SANAIANKAKGGGYESEDAYKNVEINFLDIHNIHVMRESLRKVKEACFPTTDDSKWQTAIDNTLW 368

Human   393 LQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDW 457
            |:|:..:|..||.:.:.|:.....|:||||||||||.|:.||:.:||||:|||:.||:||:|.:|
  Fly   369 LKHIRCILAGAVRIVDKVETMSTSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEW 433

Human   458 LDFGHKFGDRCGHQENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYG 522
            |.|||||..|.||.:|.....::.|||||::|||.|:.:||...|||||.||:.:|.|.|||.:|
  Fly   434 LSFGHKFQQRIGHGDNKHSDADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFG 498

Human   523 TFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFL---YTPSSDMVLHPVCHVRALHLWTAVY 584
            |||.|...||...::..:|.|:|..:.:....:.|.|   :|..:::||.|:..||::.||..:|
  Fly   499 TFLCNTEAERVAEDLKHKTTSLWTHINSSLDQYLNPLFPSFTHGAELVLRPIASVRSVRLWKGLY 563

Human   585  584
              Fly   564  563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTMR4	NP_001364996.1	PH-GRAM_MTMR4	37..150	CDD:270150	39/146 (27%)
		PTP-MTMR4	186..493	CDD:350435	120/306 (39%)
		FYVE_MTMR4	1125..1184	CDD:277272
mtm	NP_523489.1	PH-GRAM_MTMR2_insect-like	57..159	CDD:270164	27/107 (25%)
		Myotub-related	184..509	CDD:461958	148/385 (38%)