Protein Alignment MTMR4 and CG3632

DIOPT Version :9

• Sequence 1: NP_001364996.1
• Gene: MTMR4 / 9110
• HGNCID: 7452
• Length: 1209
• Species: Homo sapiens
• Sequence 2: NP_001096996.1
• Gene: CG3632 / 32589
• FlyBaseID: FBgn0030735
• Length: 1250
• Species: Drosophila melanogaster
• Alignment Length: 1364
• Identity: 449/1364 - (32%)
• Similarity: 624/1364 - (45%)
• Gaps: 351/1364 - (25%)

Human    20 PPSLEYIQAKDLFPPKELVKEEENLQVPFTVLQGEGVEFLGRAADALIAISNYRLHIKFKDSV-- 82
            |||:.:|:|.:.:|..::.||:..|.|||..|.||.:::|||..|.::|:||||:.:. |.|.
  Fly    16 PPSICFIRAAESYPKSQMEKEDSQLFVPFQELAGESIKYLGRTDDGILALSNYRIFLS-KQSTGY 79

Human    83 -INVPLRMIDSVESRDMFQLHISCKDSKVVRCHFSTFKQCQEWLSRLSRATARPAKPEDLFAFAY 146
             ..|||.:|:||:.||:|||.::|||:..|||.|.:.:||.:|..|:......|...|.||||.:
  Fly    80 ETYVPLGLIESVQVRDLFQLIVNCKDASTVRCSFPSAEQCSDWQRRIHLMIGVPESLETLFAFPF 144

Human   147 HAWCL-------------------GLTEEDQ----HTHLCQPGEHIRC----------------- 171
            ::|..                   ||..:|:    |..|.:|..::..
  Fly   145 YSWTCDVLGSGNGSGIVSAQANGNGLIAKDRCLTLHNGLAKPTANVTASNPLPDPASETISAAMS 209

Human   172 -------RQEA----ELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFR 225
                   |.|:    |:||:||||:..||:|..|:::|||||||.|||||..|||:.|.|||:||
  Fly   210 NRLQRSVRYESDFKNEVARLGFDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFR 274

Human   226 SWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRA--------- 281
            ..:|:|.||:||.::||.:|||||||:.|.||||..||.|:.::|.|||.|.|..|
  Fly   275 GSRRLPAVVWRHQKSGAILARCSQPEVGWLGWRNTRDEQLLKALADACAFDRGEHARHSTCANAK 339

Human   282 ---TGGSLST-GNNDTSEACDADFDSSLTACSGVESTAAP-QKLLILDARSYTAAVANRAKGGGC 341
               |.||..| |.:..|.......|.|    |..|.|... :|:||:||||||:||.|||:||||
  Fly   340 AQPTKGSKETNGQSGLSGKSSPSLDDS----SHEELTLDEIKKILIVDARSYTSAVTNRARGGGC 400

Human   342 ECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLV 406
            ||.||||..|:.||.:.||||||.||..:|.:|:..||..||...||.|.|:||||.:|.|.:.|
  Fly   401 ECIEYYPCAEIEFMNLGNIHAIRKSFHAVRQLCASSPDDPNWYGQLEKTMWMQHLSGLLGATMTV 465

Human   407 ANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQ 471
            .:|:::.||||||||||||||||||||.|::.|||||||:|||:||||.:||:|||||.||.|:.
  Fly   466 VHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGFRVLVEREWLNFGHKFADRSGNG 530

Human   472 ENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRN 536
            .|.::.||:|||||||||.|||:.:|:||.|||:.::|:||.||:.|||:||||.|:..||.:.:
  Fly   531 PNSDEVNERCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSLSCLFGTFLCNSLRERIENS 595

Human   537 IYKRTCSVWALLRAGNKNFHNFLYTPSSDMVLHPVCHVRALHLWTAVYLPASSPCTLGEEN-MDL 600
            ::.||.|||..|  ....:.|.||...::.||.|...||.|:.|:.|||.     :||.:| .||
  Fly   596 VFDRTFSVWPFL--AETMYRNPLYKHETEKVLWPAHSVRFLYFWSDVYLG-----SLGNKNGTDL 653

Human   601 YLSPVAQSQEFSGRSLDRLPKTRSMDDLLSACDTSSPLTRTSSDPNL-------------NNHCQ 652
               |:..::..||.: ..:.||||.:||.:.....|.::|.||||||             :|...
  Fly   654 ---PLLSNERQSGHN-GLMAKTRSSEDLTTNELGQSTISRRSSDPNLTVESIVTDCFNANSNSMF 714

Human   653 EVRVGLEPWHSNPEGSETSFVDSGVGGPQQT----VGEVGLP-PPLP--------SSQKDYLSNK 704
            ::|  .|..:|..|..:.|..||.......|    ||..|.. .|:|        :|::|.|..:
  Fly   715 DIR--SEANNSVSENVQESVKDSKEVELDVTDATEVGPCGRSNNPIPDFHNDQSTASKRDILEVE 777

Human   705 --------------------------------PFKSHKSCSPSYKL--------------LNTAV 723
                                            |.:|.:|.:.|.||              .|...
  Fly   778 SQTQRRSSLESSQLIPGSVFIFGSSENDKNAVPSESEESLATSQKLNSESGRPFFIFGSSENDQS 842

Human   724 PREMKS---------------NTSDPEIKVLEETKGPAPDPSAQDELGRTLDGIGEPPEHCPETE 773
            |..:||               .||...:...|..:.|..|.|::|.:            ..|..|
  Fly   843 PVPLKSEDTSDISRALWHGAIETSTDTLIPAEPVQKPNSDNSSRDHI------------TSPTME 895

Human   774 AVSALSKVISNKCDGVCNFPESSQNSPTGTPQQAQPDSMLGVPSKCVLDHSLSTVCNPPSAACQT 838
            .||...|:.|..........:|..|.|                         .....|.:..|..
  Fly   896 LVSGDRKLESTSTVQASKISQSYNNLP-------------------------KVHIRPNAVICPQ 935

Human   839 PLDPSTDFLNQDPSGSVASISHQEQLSSVPDLTHGEED------IGKRGN---NRNGQLLEN--- 891
            .:|               :..|...| .||..|.|..|      :.|..|   |.||.||.:
  Fly   936 RVD---------------AFPHHLDL-QVPRETTGNPDRCKPEKLAKDANANANANGSLLASDGY 984

Human   892 ------------PRF-GKMPLE-------LVRKPISQSQISEFSFLGSNWDSFQGMVTSFPSGEA 936
                        .|| |:.|.:       :.|.....|...:..|...|     |....|||.
  Fly   985 NGEESLFISPDLQRFVGQSPFDAPSTGGRIRRNTFGSSYSRDMKFTAEN-----GSAHQFPSS-- 1042

Human   937 TPRRLLSYGCCSKRPNSKQMRATGPCFGGQWAQREGVKSPVCSSHSNGHCTGPGGKNQMWLSSHP 1001
                    |..|..|...|.||
  Fly  1043 --------GIISLPPTPFQERA------------------------------------------- 1056

Human  1002 KQVSSTKPVPLNCPSPVPPLYLDDDGLPFPTDVIQHRLRQIEAGYKQEVEQLRRQVRELQMRLDI 1066
                   ...::||          |||.........||.||...:|...|.|.|::..:::.|..
  Fly  1057 -------QFTISCP----------DGLAHGLSEQNIRLHQIVQEHKLREEMLLREIHGMRLALLE 1104

Human  1067 RHC--CAPPAEPPMDYEDDFTCLKESDGSDTEDFGSDHSEDCLSE----ASWEP--VDKKETEVT 1123
            :.|  |.......|::|         :|||..:..|..|.:.:.|    ||:.|  :.:|:....
  Fly  1105 KGCPSCNSIVSTNMEHE---------NGSDIVENASTCSWEAVEERSGPASYAPSSIQEKKASSV 1160

Human  1124 RWVPDHMASHCYNCDCEFWLAKRRHHCRNCGNVFCAGCCHLKLPIPDQQLYDPVLVCNSCYEHI 1187
            .|||||..|.|.:|..||||.:|:||||:||.:|||.|.....|:|:::|::||.:|.|||..:
  Fly  1161 LWVPDHAVSRCSSCQTEFWLGRRKHHCRSCGEIFCADCSEFWAPLPNEKLFNPVRLCGSCYTSV 1224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTMR4	NP_001364996.1	PH-GRAM_MTMR4	37..150	CDD:270150	48/115 (42%)
		PTP-MTMR4	186..493	CDD:350435	177/320 (55%)
		FYVE_MTMR4	1125..1184	CDD:277272	30/58 (52%)
CG3632	NP_001096996.1	PH-like	35..147	CDD:302622	48/112 (43%)
		Myotub-related	221..590	CDD:284109	205/372 (55%)
		FYVE_MTMR4	1162..1221	CDD:277272	30/58 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155566
Domainoid	1	1.000	454	1.000	Domainoid score	I506
eggNOG	1	0.900	-	-		E1_KOG4471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	675	1.000	Inparanoid score	I728
Isobase	1	0.950	-	0	Normalized mean entropy	S3513
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191120at33208
OrthoFinder	1	1.000	-	-		FOG0004824
OrthoInspector	1	1.000	-	-		otm40420
orthoMCL	1	0.900	-	-		OOG6_105196
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2890
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.710