Protein Alignment MTMR4 and CG14411

DIOPT Version :10

• Sequence 1: NP_001364996.1
• Gene: MTMR4 / 9110
• HGNCID: 7452
• Length: 1209
• Species: Homo sapiens
• Sequence 2: NP_572972.1
• Gene: CG14411 / 32408
• FlyBaseID: FBgn0030582
• Length: 843
• Species: Drosophila melanogaster
• Alignment Length: 783
• Identity: 174/783 - (22%)
• Similarity: 276/783 - (35%)
• Gaps: 262/783 - (33%)

Human    30 DLFPPKELVKEEE----NLQVPFTVLQGEGVEFLGRAADALIAISNYRLHIKFKDSVINVPLRMI 90
            ||:.....:...|    |:...:|:.:      |||||.||.|......|..........|.:.
  Fly   143 DLYQENTYLGRNEITLNNIDHIYTITE------LGRAASALQAARGMASHAGMSRRKKLEPFKQ- 200

Human    91 DSVESRDMFQLHISCKDSKVVRCHFSTFKQCQEWLSRLSRAT-------------ARPAKPEDLF 142
            .::..| :..|||.||:.::::..|      |:..|::..|:             |.|.:.:..|
  Fly   201 QNISGR-IAALHIVCKNFRLLKFAF------QQQDSKMFGASDQGKLIASALVRFAYPMRHDLSF 258

Human   143 AFAYHAWCLGLTEEDQHTHLCQPGEHIRCRQE---AELARMGFDLQNVWRVSHINS--------- 195
            |:|:        .|..::.|...|..:...:.   .||.|.|   ...|:|....|
  Fly   259 AYAH--------REPYYSTLGASGTSMYATKNDWARELIRCG---ATEWQVVSCASVQLLQNPLQ 312

Human   196 --NYKLCPSY--PQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCS--QPEISW 254
              .|.:.|.:  |:...|     |:.|:...:|.. .|....||.: .:.||:.|.:  ||...
  Fly   313 AGKYTVPPHFVIPKSCSV-----DRFLDLSRAFCD-SRAAFWVYSY-GSSAALVRLAELQPAAQ- 369

Human   255 WGWRNADDEYLVTSIAKACALDPGTRATGGSLSTGNNDTSEACDADFDSSLTACSGVESTAAPQK 319
               ::...|.::..:.:.|  |.|.:.                                     |
  Fly   370 ---QDTKSENVMLELVRKC--DAGRQL-------------------------------------K 392

Human   320 LLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQ------MP 378
            ||.|..|                              :.:|..:..::|.||.:|:.      |.
  Fly   393 LLQLTDR------------------------------LPSIQDVLRAYQKLRRLCTPETPEKFML 427

Human   379 DPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYY 443
            ....:|..||.|.||.::|:.|:.|...:.|: |.|...::..|:|.|....|.:||::||||::
  Fly   428 QDDKYLGLLEKTNWLFYVSLCLRYASEASATL-RSGVTCVLQESNGRDLCCVISSLAQLLLDPHF 491

Human   444 RTLEGFQVLVESDWLDFGHKFGDRCGHQENVED--------QNEQCPVFLQWLDSVHQLLKQFPC 500
            ||::|||.||:.:|:...|.|..|.||....:.        .:||.||||.:||.|.|||:|||.
  Fly   492 RTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNAELFDSEQSPVFLLFLDCVWQLLQQFPD 556

Human   501 LFEFNEAFLVKLVQHTYSCLYGTF-----------------------------------LANNPC 530
            .|||.:.:|..|....:..::.||                                   ..:||.
  Fly   557 EFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVLRPVWDWGEQFSDKDKMFFSNPL 621

Human   531 EREKRN---------IYKRTCSVWALLRAGNKNFHNFL--YTPS----------------SDMVL 568
            .:.:|.         .::|:.:|      |:|..|...  .|||                .|..|
  Fly   622 YQRQRGDLGAQAAAVAHRRSLAV------GSKGAHGAASGVTPSRNTINPQLFATASSVPQDRYL 680

Human   569 HPVCHVRALHLWTAVY---LPASSPCTLGEENMDLY----LSPVAQSQEFSGRSLDRLPKTRSMD 626
            .|...:..|.:|...|   ||.......|:..:|||    ||.:|:.|    |.||    .::.|
  Fly   681 QPAHRIFDLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIAKVQ----RCLD----YQNFD 737

Human   627 DLLSA----CDTSSPLTRTSSDPNLNNHCQEVRVGLEPWHSNPEGSETSFVDSGVGGPQQTVGEV 687
            ||..|    ...|.|          |.|..|     :|    .:..|..||| ||...::...:.
  Fly   738 DLPDAYYEFAGESRP----------NQHKDE-----KP----DKEDEAEFVD-GVERRRKPTAKA 782

Human   688 GLP 690
            ..|
  Fly   783 ATP 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTMR4	NP_001364996.1	PH-GRAM_MTMR4	37..150	CDD:270150	28/129 (22%)
		PTP-MTMR4	186..493	CDD:350435	77/335 (23%)
		FYVE_MTMR4	1125..1184	CDD:277272
CG14411	NP_572972.1	PH-like	<114..225	CDD:473070	22/95 (23%)
		PTP-MTMR10-like	343..549	CDD:350385	67/280 (24%)