Protein Alignment MTMR4 and mtm-3

DIOPT Version :9

• Sequence 1: NP_001364996.1
• Gene: MTMR4 / 9110
• HGNCID: 7452
• Length: 1209
• Species: Homo sapiens
• Sequence 2: NP_001022794.2
• Gene: mtm-3 / 175490
• WormBaseID: WBGene00003476
• Length: 1006
• Species: Caenorhabditis elegans
• Alignment Length: 1230
• Identity: 269/1230 - (21%)
• Similarity: 431/1230 - (35%)
• Gaps: 503/1230 - (40%)

Human    33 PPKELVKEEENL----QVPFTVLQGEGVEFLGRAAD-----ALIAISNYRLHIKFKDSVINVPLR 88
            ||  :.:|.||:    :....:|.||....:.:..:     ..:.::|:|:.:..||..:...||
 Worm    77 PP--VTEESENMPQNYETVVELLPGEERAPINKLTEFPIEGGSLFVTNFRIVVILKDKEVEEALR 139

Human    89 M----IDSVESRDM----FQLHISCKDSKVVRCHFSTFKQC------------------------ 121
            .    :..:|..|:    | :|:|.|..::....|.|.:..
 Worm   140 FLVFPLQDIEQIDLAIPAF-IHLSLKIGRMFTICFKTAEDAALVHKILYTAFQRLNRPISSIYTS 203

Human   122 --QEWLSRLSRATARPAKPEDLFAFAYHAWCLGLTEEDQHTHLCQPGEHIRCRQEA-ELARMGFD 183
              |:|   .|:.|..|.:..:.||:.:..   .:.|.|:...|  |...:|....| |:..:.|:
 Worm   204 RPQDW---TSKNTDNPMQSLNAFAWKFSE---AVDELDRDGKL--PSWLLRADSVAQEITHIDFN 260

Human   184 ---LQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIA 245
               :...:::|.:|.|:::||:||:|::||..|||.::...|.:||..|.|.|::|..:..|.:.
 Worm   261 RLGMSEHFQISSVNENFEVCPTYPEKIIVPKGITDDDIRKGAPYRSIGRFPAVIWRCRKTRAVLM 325

Human   246 RCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRATGGSLSTGNNDTSEACDADFDSSLTACSG 310
            |.|||::....|||..||.::....||..::                                 |
 Worm   326 RSSQPQVGILSWRNPTDEKIIEEAVKASRIE---------------------------------G 357

Human   311 VESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCS 375
            .|.    ::.:|:|||.||:|.||||:.||.|..|||...::.|:|:.||||:|.||..:|.:..
 Worm   358 EEK----KQFIIMDARGYTSAFANRARSGGFENTEYYQQAKLEFLGLPNIHAVRGSFNNVRTMLH 418

Human   376 QMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDR--EGRPVLVHCSDGWDRTPQIVALAKIL 438
            .:......|::|::|.||.:||.:|   |..||..|.  :|..||||||||||||.|:..||||:
 Worm   419 NLGPNEQLLTSLQTTGWLLNLSNLL---VNAANCADHLSKGHSVLVHCSDGWDRTTQVTTLAKIM 480

Human   439 LDPYYRTLEGFQVLVESDWLDFGHKFGDR----CGHQENVEDQNEQCPVFLQWLDSVHQLLKQFP 499
            ||.||||::||:.|:..||:.||||..||    .|   |....:|:.|||||:|::|..|.::.|
 Worm   481 LDEYYRTVKGFEELIRRDWIAFGHKLYDRQLVAFG---NWGTSDERSPVFLQFLEAVRHLQREQP 542

Human   500 CLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTC-----SVWALLRAGNKNFHNFL 559
            .||:|..|:|:||.:|.||.|:|:||.|:  .:|:|...:: |     .:|..:...|:.:.|..
 Worm   543 TLFQFTHAYLIKLAKHAYSGLFGSFLFNS--HKERREAMEK-CKGTLVDIWRFIGPHNEEYVNQS 604

Human   560 YTPSSDMVLHPV-CHVRALHLWTAVYLPASSPCTLGEENMDLYLSPVAQSQEFSGRSLDRLPKTR 623
            :.......:.|| ..|..|.:|..|:...       ||:.....||..:..
 Worm   605 FDEHYTGAVKPVNVSVINLRVWHEVFADE-------EEHYTQIFSPKEERP-------------- 648

Human   624 SMDDLLSACDTSSPLTRTSSDPNLNNHCQEVRVGLEPWHSNPEGSETSFVDSGVGGPQQTVGEVG 688
                 ||.|.|  |: .||:..||
 Worm   649 -----LSGCTT--PM-NTSTSTNL----------------------------------------- 664

Human   689 LPPPLPSSQKDYLSNKPFKSHKSCSPSYKLLNTAVPREMKSNTSDPEIKVLEETKGPAPDPSAQD 753
                                                  :||.:|
 Worm   665 --------------------------------------VKSKSS--------------------- 670

Human   754 ELGRTLDGIGEPPEHCPETEAVSALSKVISNKCDGVCNFPESSQNSPTGTPQQAQPDSMLGVPSK 818
                               |::::|:      .||  :..||||..||
 Worm   671 -------------------ESINSLN------VDG--SAKESSQQHPT----------------- 691

Human   819 CVLDHSLSTVCNPPSAACQTPLDPSTDFLNQDPSGSVASISHQEQLSSVPDLTHGEEDIGKRGNN 883
                      |:...:.....|..||.|:.|.        .:|.::..|..:            :
 Worm   692 ----------CSTTPSDNTNSLPMSTSFIQQS--------LYQPKVRGVAAI------------D 726

Human   884 RNGQLLENPRFGKMPLELVRKPISQSQISEFSFLGSNWDSFQGMVTSFPSGEATPRRLLSYGCCS 948
            |:|.:    ||......::||
 Worm   727 RDGVI----RFEDDEQAMLRK-------------------------------------------- 743

Human   949 KRPNSKQMRATGPCFGGQWAQREGVKSPVCSSHSNGHCTGPGGKNQMWLSSHPKQVSSTKPVPLN 1013
                                                                             
 Worm   744 ----------------------------------------------------------------- 743

Human  1014 CPSPVPPLYLDDDGLPFPTDVIQHRLRQIEAGYKQE-VEQLRRQVRELQMRLDIRHCCAPPAEPP 1077
                                  :::||..|...|.| :|:|||:.     .||..
 Worm   744 ----------------------KNKLRAEEIRRKDEKIEELRRRA-----VLDTN---------- 771

Human  1078 MDYEDDFTCLKESDG-------SDTEDFGSDHSEDCLSEASW-EPVDKKETEVTRWVP----DHM 1130
                      |.|.|       ||.|..|:  .|..:|:.|. :||:    |:..:.|    :..
 Worm   772 ----------KVSPGQRQSYSESDVETTGT--LERVMSDVSMVDPVN----ELPHFKPNTTWEGE 820

Human  1131 ASHCYNCDCEF-----WLAKRRHHCRNCGNVFCAGCCHLKLPIPDQQLYDPVLVCNSCYE 1185
            :.||..|..||     ::..|:|||||||.|.|..|...:..:.::........|:|||:
 Worm   821 SGHCAYCKKEFNKLSVYVEDRQHHCRNCGRVVCEDCSKNRFSVIEEGKSVQKRACDSCYD 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTMR4	NP_001364996.1	PH-GRAM_MTMR4	37..150	CDD:270150	27/155 (17%)
		PTP-MTMR4	186..493	CDD:350435	118/312 (38%)
		FYVE_MTMR4	1125..1184	CDD:277272	19/67 (28%)
mtm-3	NP_001022794.2	Myotub-related	258..574	CDD:284109	136/360 (38%)
		FYVE	814..883	CDD:214499	20/67 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161463710
Domainoid	1	1.000	254	1.000	Domainoid score	I1244
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I1648
Isobase	1	0.950	-	0	Normalized mean entropy	S3513
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191120at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105196
Panther	1	1.100	-	-	O	PTHR10807
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2890
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.850