Protein Alignment FMNL3 and mwh

DIOPT Version :10

• Sequence 1: XP_011537270.1
• Gene: FMNL3 / 91010
• HGNCID: 23698
• Length: 1047
• Species: Homo sapiens
• Sequence 2: NP_001261244.1
• Gene: mwh / 38131
• FlyBaseID: FBgn0264272
• Length: 1069
• Species: Drosophila melanogaster
• Alignment Length: 654
• Identity: 127/654 - (19%)
• Similarity: 227/654 - (34%)
• Gaps: 198/654 - (30%)

Human    24 GKWCRWHLS-ARQLCE----GPKGCGPYILWPSAFPPASSGDRSSMNLPPDKARLLR----QY-- 77
            |:..:.||. |..:||    |..|..|        |..:||..||.......|..|.    .|
  Fly   225 GQLGQLHLEMAPSVCEMAGQGQSGPVP--------PQKASGSNSSKGTNKCGASSLNGSLASYKI 281

Human    78 -DNEKKWD----LICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFR------------------ 119
             .:|:.|.    ...:.:|..|.| |..|:..|:.|:..|.:.||..
  Fly   282 GGSEQSWPQAPVYSKENQRPPVYN-PEDYVHSLRKFIKASGSAKKLSIYDVFTGPSPKEEASRSA 345

Human   120 -------------------------RRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLV 159
                                     |:....|.:|.:|...||.:...:|:||:.....|:..|:
  Fly   346 TLPAKHSEYKSPIPAPPENDREMSLRQFGSITDLLTKLRADLRVSFPSFVQEFVGTPADGISHLL 410

Human   160 DYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPSALSAPF---TNSLARSARQSVLR 221
            :.|                             |:|:..|..:| .||.   ::|||.:......:
  Fly   411 EVL-----------------------------RAIQMAQASNA-PAPMPGASSSLAMNRNPQSYQ 445

Human   222 YSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQY-GFNLVMSHPHAVNEIALSLNNKNPRTK 285
                  ||||.         |...|:.||....:... ....:.:.|..:..:|.|...:..|.:
  Fly   446 ------RRALL---------DELSCLQCLSICCSRSLDAIARLGNTPVGLMPLASSATGQGIRAR 495

Human   286 ALVLELLAAVC-------------LVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNID 337
            .|.|:|||:.|             :...||..:..|....:..|.|..||..|:....:...:.:
  Fly   496 ILALQLLASACDRQPFGSGSGGQKIASAGHTAVSDAMSTLRLRCSEPVRFRLLVGILNSGGGSGE 560

Human   338 FMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLE-EFLQKSRHTES---EKLQVQIQAYLDNVF 398
            ...|.::|:|..:.|...:..|:::|.|..:.||: ..|.::..:.|   :.|:::::.:.:...
  Fly   561 LQCAGVKFLNTFIESAVSIQQRLYIQAELFQAGLDASTLARTISSSSPWLDALKIEVKRFNELHI 625

Human   399 DVGGLL---EDAE---TKNVALE-KVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKEL 456
            ||..::   .|||   ::.|.|| :|:.|.|..:.||    .:|.....|.|||::::.:.:...
  Fly   626 DVDQMITRARDAERVRSQMVILERRVQILHEEKAVLT----SMERRLQERCAELQREIFRLQGTQ 686

Human   457 ESIKETYENTSHQVHTL----------------------------------------------RR 475
            :..|.....:|||...|                                              |:
  Fly   687 QQSKFKPVESSHQPVALPRQVPPPKKNKQNSSEHEDEGISSSETGASLSPVPILILPSKAKPSRK 751

Human   476 LIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPP 540
            :::|.|:   ....:|..:..|:::.|||..::.....|...|    .:....|..:|::|:...
  Fly   752 VVEEDED---DAATIEDVIEELDNIVSEAEKQISSQTSSVTRP----KMRHHRPVEKEIVPVNIV 809

Human   541 PAPP 544
            |.||
  Fly   810 PQPP 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FMNL3	XP_011537270.1	Drf_GBD	64..297	CDD:461886	54/303 (18%)
		Drf_FH3	300..497	CDD:461885	47/253 (19%)
		FH2	580..945	CDD:396655
mwh	NP_001261244.1	Drf_GBD	<349..506	CDD:461886	38/201 (19%)
		Drf_FH3	524..725	CDD:461885	43/204 (21%)