Protein Alignment FMNL3 and dia

DIOPT Version :10

• Sequence 1: XP_011537270.1
• Gene: FMNL3 / 91010
• HGNCID: 23698
• Length: 1047
• Species: Homo sapiens
• Sequence 2: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Alignment Length: 1086
• Identity: 277/1086 - (25%)
• Similarity: 463/1086 - (42%)
• Gaps: 255/1086 - (23%)

Human    64 MNLPPDKARLLRQYDNEKKWDLI------------CDQERFQVKNPPHTYIQKLQSFLDPSVTRK 116
            ||:|.||...|.....|::..:|            ....||:   .|..|::.||:  ....|.|
  Fly    85 MNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDYVEYLQN--GEHSTHK 144

Human   117 KFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDD 181
            .:        :.:..|.::|.:|.|.|::|                        |...|:
  Fly   145 VY--------QCVESLRVALTSNPISWIKE------------------------FGVAGI----- 172

Human   182 GAFDKLRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVC 246
            |..:||                       ||||                 ||:  .|.:......
  Fly   173 GTIEKL-----------------------LARS-----------------KNN--ASYEKIEFEA 195

Human   247 ILCLRAIMNYQYGFNLVMS-HPHA-VNEIALSLNNKNPRTKALVLELLAAVCLV--RGGHEIILA 307
            |.||:||||..:|.|:|:: ..|: |..:|.||:.:.|:|....|:|||:.|:|  |.|:|.:|.
  Fly   196 IRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLR 260

Human   308 AFDNFKEVC-KELHRFEKLME-YFRNEDSNIDFMVAC--MQFINIVVHSVEDMNFRVHLQYEFTK 368
            |........ |...||..::: .|.::..:....:||  :.|||.:.::..|:|||:||:.|..:
  Fly   261 AITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMR 325

Human   369 LG----LEEFLQKSRHTESEKLQVQIQAY--------------LDNV----------FDV-GGLL 404
            :|    |:||.:....:.:|.||...:.:              .|||          ||| ..|:
  Fly   326 MGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLV 390

Human   405 EDAETKNVALEKVEEL-----------------EEHVSHLT--EKLLD--LENENM-MRVAELEK 447
            .|..::...|..::.|                 ||.:|.:.  :...|  .||.|. :..:.|..
  Fly   391 TDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLD 455

Human   448 QLLQREKELESIK-ETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPA 511
            .::::.|..||.: |.||....|:.:      .|:||..:..|||..|:.:|   :..:|...|.
  Fly   456 DIVEKAKAKESKRSEEYEKKIEQLES------AKQEAEAKAAHLEEKVKLME---ANGVAAPSPN 511

Human   512 ELSE---GMPPSDLDLLAPAPPPEEVLP------LPPPPAPPLP-----PPPPPLPDKC--PPAP 560
            :|.:   .|||.........|||...:|      .||||.||:|     |||||.|...  ||.|
  Fly   512 KLPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPP 576

Human   561 PLPG--------------AAPSV-VLTVGLSAIR---IKKPIKTKFRLPVFNWTALKPNQISGTV 607
            |:||              ..|.| ||..||...:   :|.|:|..      ||.|:.|.::|...
  Fly   577 PMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRA------NWKAIVPAKMSDKA 635

Human   608 F-SELDDEKILEDLDLDKFEELFKT----KAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLA 667
            | .:..::|:.:|..|.:....|.:    |.|..|:|    |..|..|....:.:|::..|:|||
  Fly   636 FWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVDLRVLDSKTAQNLA 696

Human   668 ITLRKAGR--SAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAED 730
            |.|..:.:  |.|:|...:...|...|..:.::.|:::||....:|.|::.:.:.:||..:   :
  Fly   697 IMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI---E 758

Human   731 RFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNY 795
            :|.....:::||:.|:..:.|...:.|.:|.:.|.:.|..||...:::|:|..::||:||.||||
  Fly   759 QFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNY 823

Human   796 MNS-SKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 859
            ||| ||..|.:||::..|..|.:||..|.|.||||::|..|::|:||..||:.:|..|.||:.|:
  Fly   824 MNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVN 888

Human   860 LENVLLDVKELGRGMELIRRECSIHDN-----------SVLRNFLSTNEGKLDKLQRDAKTAEEA 913
            ::.:...::::...::.:  |..:.:|           .|:..|......::|.|.:.....|:.
  Fly   889 MDAIQKAMRQMNSAVKNL--ETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKL 951

Human   914 YNAVVRYFGESPKTTPPSVFFPVFVRF-----------IRSYKEAEQENEARKKQEEVMREKQLA 967
            |..:..|:...|.......||.....|           :|..:|.|::...::.:|:..||:|..
  Fly   952 YKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQER 1016

Human   968 QEAKK--LDAKTPSQRNKWQQQELIAEL--------RRRQAKEHRP 1003
            |:.||  :|...| |..:.....|:..|        |.|||:..||
  Fly  1017 QQRKKAVVDMDAP-QTQEGVMDSLLEALQTGSAFGQRNRQARRQRP 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FMNL3	XP_011537270.1	Drf_GBD	64..297	CDD:461886	55/246 (22%)
		Drf_FH3	300..497	CDD:461885	59/252 (23%)
		FH2	580..945	CDD:396655	104/394 (26%)
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	55/246 (22%)
		Drf_FH3	253..453	CDD:461885	44/199 (22%)
		FH2	608..983	CDD:396655	103/389 (26%)