Protein Alignment FMNL3 and capu

DIOPT Version :10

• Sequence 1: XP_011537270.1
• Gene: FMNL3 / 91010
• HGNCID: 23698
• Length: 1047
• Species: Homo sapiens
• Sequence 2: NP_001137784.1
• Gene: capu / 33611
• FlyBaseID: FBgn0000256
• Length: 1361
• Species: Drosophila melanogaster
• Alignment Length: 1162
• Identity: 237/1162 - (20%)
• Similarity: 406/1162 - (34%)
• Gaps: 366/1162 - (31%)

Human    48 LWPSAFPPASSGDRSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPS 112
            |.|....|.::|..|.                      :.:.|.|.|.......:|.|.|....:
  Fly   323 LTPGTMEPCAAGSGSP----------------------LANGELFNVSKAKKVELQNLSSRFTAA 365

Human   113 VTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEG-- 175
            ||:..  ..|..||.  .|..::.....:|     ....:..|:        .|.:|:..|:.
  Fly   366 VTQTP--PGVTSSTP--NESGVTGPAGPLG-----ATTSSPSLE--------TQSTVIISFKSSQ 413

Human   176 --LESGDDGAFDKLRSWSRSIED-------LQPPSALSAPFTNSLARSARQSVLRYSTLPGRRAL 231
              ::|..:.|.      |.::||       ..||.....|.|..|:.:..:.|..: |:....|.
  Fly   414 TPVQSQTNSAA------SENVEDDTAPLPLPPPPPGFGTPTTPLLSSNVLKKVASF-TVEKSSAG 471

Human   232 KNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELL---- 292
            .||     .:..::|                    |.:.....|:    .|.:.:|.:..|
  Fly   472 NNS-----SNPPNLC--------------------PTSDETTLLA----TPCSSSLTVATLPPEI 507

Human   293 ---AAVCLVRGG-----------HEIILAAFDNFKEVCKELHRFEKLMEYF----------RNED 333
               ||...|.||           .::..||::.|:.        :.|:::.          .:.|
  Fly   508 AVGAAAGGVAGGAGSRRGSSYVPEKLSFAAYEKFEG--------QMLIKWLISTMQSNPKSSSGD 564

Human   334 SNID-FMVACMQFINIVVH-------SVE--DMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQV 388
            :|.: |....:||.|.:.:       |.|  |..|..:..|::|            |||.....:
  Fly   565 ANQELFNTLALQFCNNLKYVGVLKQISNEHLDCGFSPYEMYQWT------------HTEQPTTSL 617

Human   389 QI-QAYLDNVF-------------------------DVGGLLEDAETKNVALEKVEELEEHVSHL 427
            .: ...||.|.                         .|.|.|....|.:.|....::..:.:  |
  Fly   618 PLTPGKLDKVAAWPFSSTPSGIRALESASLASLGAGGVAGSLATIATASTASSDNQKTLQQI--L 680

Human   428 TEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEP 492
            .::||     |...:||:...:   .:.|.|:.|.....|.:...|..|:...|...     .|.
  Fly   681 KKRLL-----NCTTLAEVHAVV---NELLSSVDEPPRRPSKRCVNLTELLNASEATV-----YEY 732

Human   493 NVRG--------------LESVDSEALARVG------------------PAELSEGMPPSDLDL- 524
            |..|              .||.|.|...:.|                  |..::...||....|
  Fly   733 NKTGAEGCVKSFTDAETQTESEDCEGTCKCGQSSTKVSDNESAKEDGEKPHAVAPPPPPPPPPLH 797

Human   525 --LAPAPPPEEVLPLPPPPAPPL-------------------PPPPPPLPDK----CPPAPPLPG 564
              :||.|||    |.||||.|||                   ||||||.|.:    .||.||...
  Fly   798 AFVAPPPPP----PPPPPPPPPLANYGAPPPPPPPPPGSGSAPPPPPPAPIEGGGGIPPPPPPMS 858

Human   565 AAPSVVL-------------------TVGLSAIRIKKPIKTKFRLPVFNWT--------ALKPNQ 602
            |:||...                   |:..||:...||::     |:: ||        |.:|..
  Fly   859 ASPSKTTISPAPLPDPAEGNWFHRTNTMRKSAVNPPKPMR-----PLY-WTRIVTSAPPAPRPPS 917

Human   603 ISGT--------------------------------VFSELDDEKILEDLDLDKFEELFKTKAQG 635
            ::.:                                :::|:::..:  | ::|:|.|||..:|..
  Fly   918 VANSTDSTENSGSSPDEPPAANGADAPPTAPPATKEIWTEIEETPL--D-NIDEFTELFSRQAIA 979

Human   636 PALDLICSKNKTAQ-KAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVEC 699
            |.     ||.|..: |.|..:.:|:..|::|:.|..|.....:.||..||:..|...:.::.::.
  Fly   980 PV-----SKPKELKVKRAKSIKVLDPERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEALQH 1039

Human   700 LMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTP 764
            :.....||.|::.:::......||:.   .::|:|..|.:...::|::.:.|...|::::.:|..
  Fly  1040 MSNIQATEDELQRIKEAAGGDIPLDH---PEQFLLDISLISMASERISCIVFQAEFEESVTLLFR 1101

Human   765 QLNAIIAASASVKSSQKLKQMLEIILALGNYMN--SSKRGAVYGFKLQSLDLLLDTKSTDRKMTL 827
            :|..:...|..:..|:.||.:..|||.||||||  :.:||...||.|..|..|.|.||.:...||
  Fly  1102 KLETVSQLSQQLIESEDLKLVFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSKESHTTL 1166

Human   828 LHFIA--------------LTVKEKYPDLANFWHELHFVEKAAAVSLENVL-----LDVKELG-- 871
            ||||.              |.::...|:.|:       ||:||.:..|.|.     |:.|.||
  Fly  1167 LHFIVRTYIAQRRKEGVHPLEIRLPIPEPAD-------VERAAQMDFEEVQQQIFDLNKKFLGCK 1224

Human   872 ----RGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKT----- 927
                :.:...|.|......|.:..|:...:..:.||.:......:.:...:|::..|||.
  Fly  1225 RTTAKVLAASRPEIMEPFKSKMEEFVEGADKSMAKLHQSLDECRDLFLETMRFYHFSPKACTLTL 1289

Human   928 --TPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRN 982
              ..|..||..:..|...:|:. .:.|......|:|::.:.||...:.:..|..:::
  Fly  1290 AQCTPDQFFEYWTNFTNDFKDI-WKKEITSLLNELMKKSKQAQIESRRNVSTKVEKS 1345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FMNL3	XP_011537270.1	Drf_GBD	64..297	CDD:461886	40/250 (16%)
		Drf_FH3	300..497	CDD:461885	45/267 (17%)
		FH2	580..945	CDD:396655	100/439 (23%)
capu	NP_001137784.1	FH2	888..1315	CDD:214697	103/451 (23%)