Protein Alignment FMNL3 and DAAM

DIOPT Version :10

• Sequence 1: XP_011537270.1
• Gene: FMNL3 / 91010
• HGNCID: 23698
• Length: 1047
• Species: Homo sapiens
• Sequence 2: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Alignment Length: 1180
• Identity: 323/1180 - (27%)
• Similarity: 506/1180 - (42%)
• Gaps: 275/1180 - (23%)

Human    58 SGDRSSMNLPPDKARLLRQYDNEKKWDLICDQER------FQVKNPPHTYIQK----LQSFLD-- 110
            ||:.||...|     |.:.|.:::|..:...:.|      |:...||...:.:    ||:...
  Fly   289 SGNTSSNETP-----LQKHYRHQQKKKMPGFRGRRVWCGCFKDDEPPEICVVEGAFTLQTLTPTQ 348

Human   111 --PSVTR--KKFRRRVQE--STKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSV 169
              |||..  .||...|:|  .|...:|..:||.... .|.                    ..||.
  Fly   349 PMPSVDELDTKFAELVEELDLTAPNKEAMLSLPAQK-KWQ--------------------IYCSR 392

Human   170 MFDFEGLESGDDGAFDKLRSWSRSIE---------DLQPPSALS----------APFTNSLARSA 215
            ....:..:..|..|..:..:....||         .|.|..:.|          |.|.::|..:.
  Fly   393 KLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPSHELGNRLDGHAAFVDALKTAL 457

Human   216 RQS----VLRYSTLPGRRALKNSRLVSQKD------DVHVCIL-CLRAIMNYQYGFNLVMSHPHA 269
            |.|    |||:..|.|..||.:  |:.|.|      .:|..:: |::|:||...|...|::||.|
  Fly   458 RTSTHSFVLRFVELDGLPALLD--LLLQLDIRVANSPLHTSLIGCIKALMNNSMGRAHVLAHPTA 520

Human   270 VNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLME------- 327
            ::.||.||...|.|||...||:|.|||||.|||..:|.|..:|:....|..||:.::.
  Fly   521 IDTIARSLAADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQVFATERTRFQSIVNDLDRSTY 585

Human   328 YFRNEDSNIDFMVACMQFINIVVH---SVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQ-- 387
            .:|:   |::...|.|.|:|.|::   ..|::.||:||:|||..||::..:.|.|..|:|.|.
  Fly   586 AYRD---NVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRH 647

Human   388 ----VQIQAYLDNVFDVGGLLEDAETKNV---------------ALEKVEELEEHV------SHL 427
                ..::|..:..|......|..:||:.               |...:..|.:|:      .|.
  Fly   648 LDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLLPYTGHC 712

Human   428 TE-----------------------------------KL-------------LDLENENMMRVAE 444
            ||                                   ||             |.::...::|:..
  Fly   713 TEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLV 777

Human   445 LEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGL---------ESV 500
            .|:||.|..|..:.::.  ||...|    .||.|:::|...|....|....||         ||.
  Fly   778 KEEQLTQARKRADELER--ENFDVQ----SRLAKKEQELDLRMQEKEDLETGLARMRERLEKESA 836

Human   501 D-SEALARVGPAEL-----------------------SEGMPPSDLDLLA-----------PAPP 530
            . |:|:.|...||:                       :||..|.|..:..           ||||
  Fly   837 QHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTGCNGAVSPPPAPP 901

Human   531 PEEVLPLPPPPAPP--LPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFR---- 589
            ..:.:|.||||..|  :||||||    ||.|||.|   ||:..|:..:..::..|.|...:
  Fly   902 MLKAIPPPPPPMAPSMMPPPPPP----CPGAPPPP---PSMAQTMAPAPPKVDLPKKNVPQPTNP 959

Human   590 LPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFK-------TKAQGPALDLICSKNKT 647
            |..|||:.|...::.|||:||||:.|:..:::|:..::||.       :...|...||..:....
  Fly   960 LKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSATDGSYEDLRVTGKAA 1024

Human   648 AQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDL-QTLPVDFVECLMRFLPTEAEVK 711
            .||..|   :::..||:|..|.|.|...|..||.:||.:.|. :.|.:|.||.|::|.|:..|..
  Fly  1025 KQKVLS---VIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERA 1086

Human   712 LLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASV 776
            ||.::..:   :|.||..|||:...||:....||:..:.:...|...:..|.|::.:::.||..|
  Fly  1087 LLDEHSED---IESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREV 1148

Human   777 KSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRK-MTLLHFIALTVKEKYP 840
            ..|::|:::||::||||||||...||...||:|.||:.|.||||:..| .||||::...::.|:.
  Fly  1149 ARSRRLRKLLELVLALGNYMNRGARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFK 1213

Human   841 DLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNS-----------VLRNF-- 892
            ||.....::..|.:|:.|||..:..|::.|..|:..:.||...|.:|           |:|.|
  Fly  1214 DLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHA 1278

Human   893 -LSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEA-RK 955
             .|....:|:...:|.||   .::..||.|||......|..||.:|..|:.::.||..:||: |:
  Fly  1279 QASVRFAELEDKFQDMKT---RFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRR 1340

Human   956 KQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRR--------QAKEHRPVYEGKD-GT 1011
            :|||  .||:..||| :|..:|..::||   ..|:..:.|.        ......|...|.: |.
  Fly  1341 RQEE--EEKRAKQEA-ELKKRTIERKNK---TGLMTSVARNLGLKSGSSNGDPDSPAKGGDNKGE 1399

Human  1012 IEDIITVLKS 1021
            .:|:|:.|::
  Fly  1400 FDDLISALRT 1409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FMNL3	XP_011537270.1	Drf_GBD	64..297	CDD:461886	69/280 (25%)
		Drf_FH3	300..497	CDD:461885	60/281 (21%)
		FH2	580..945	CDD:396655	124/391 (32%)
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	59/221 (27%)
		Drf_FH3	551..737	CDD:461885	42/188 (22%)
		Smc	<765..>875	CDD:440809	25/115 (22%)
		FH2	950..1328	CDD:396655	123/386 (32%)