Protein Alignment ACVR1B and HRK1

DIOPT Version :9

• Sequence 1: NP_064733.3
• Gene: ACVR1B / 91
• HGNCID: 172
• Length: 546
• Species: Homo sapiens
• Sequence 2: NP_014910.1
• Gene: HRK1 / 854441
• SGDID: S000005793
• Length: 759
• Species: Saccharomyces cerevisiae
• Alignment Length: 383
• Identity: 87/383 - (22%)
• Similarity: 137/383 - (35%)
• Gaps: 135/383 - (35%)

Human   149 INYHQRVYHNRQRLD-------MEDPSCEMCLSKDKTLQDLVYD-------------LSTSGSGS 193
            :|.|.|..|.....|       ...||.:..||....: ::.:|             |..||:|.
Yeast   164 LNNHYRAQHPHGFTDHYAHTQSAIPPSTDSILSLSNNI-NIYHDDCILAQKYGKLGKLLGSGAGG 227

Human   194 GLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRH 258
            .:.:.|:.|...|..::|.            |.|..:.:||.::.:      ..||......|.|
Yeast   228 SVKVLVRPTDGATFAVKEF------------RPRKPNESVKEYAKK------CTAEFCIGSTLHH 274

Human   259 ENILGFIAADNKADCSFLTLPWEVVMVSAAPKLRSLRLQYKGGRGRARFLFPLNNGTWTQLWLVS 323
            .|::                  |.|.|.:..|      |.|
Yeast   275 PNVI------------------ETVDVFSDSK------QNK------------------------ 291

Human   324 DYHEHGSLFDY--LNRYTVTI-----EGMIKLAL-SAASGLAHLHMEIVGTQGKPGIAHRDLKSK 380
             |:|   :.:|  ::.:.|.:     .|.|...| ....|:.:||        ..|:||||||..
Yeast   292 -YYE---VMEYCPIDFFAVVMTGKMSRGEINCCLKQLTEGVKYLH--------SMGLAHRDLKLD 344

Human   381 NILVKKNGMCAIADLGLAV--RH---DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFK 440
            |.::...|:..:.|.|.||  |:   |.||....|     ||:..|:||||:..|   |.:|. :
Yeast   345 NCVMTSQGILKLIDFGSAVVFRYPFEDGVTMAHGI-----VGSDPYLAPEVITST---KSYDP-Q 400

Human   441 CADIYALGLVY---------WEIARRCNSGGVHEEYQLP---YYDLVPSDPSIEEMRK 486
            |.||:::|::|         |:..|  :|......|.:|   .:|.|.|....||:.|
Yeast   401 CVDIWSIGIIYCCMVLKRFPWKAPR--DSDDNFRLYCMPDDIEHDYVESARHHEELLK 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR1B	NP_064733.3	Activin_recp	32..105	CDD:307282
		TGF_beta_GS	178..205	CDD:312125	7/39 (18%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..539	CDD:271045	70/301 (23%)
HRK1	NP_014910.1	PKc_like	221..435	CDD:419665	68/302 (23%)
		MSCRAMM_ClfB	<469..673	CDD:411414
		PKc_like	<677..721	CDD:419665

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3189
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950