Protein Alignment ACVR1B and sax

DIOPT Version :9

• Sequence 1: NP_064733.3
• Gene: ACVR1B / 91
• HGNCID: 172
• Length: 546
• Species: Homo sapiens
• Sequence 2: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 556
• Identity: 228/556 - (41%)
• Similarity: 303/556 - (54%)
• Gaps: 104/556 - (18%)

Human    36 CTSC-------LQANYTCETDGACMVS-IFNLDGMEHHVRTCIPKVELVPAGKPFYC------LS 86
            |.||       .:..:||:....|..| ..:.||.....|.|    ...|...|..|      ::
  Fly    79 CYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGC----STSPDQLPMICSQNSLKIN 139

Human    87 SEDLRNTH------CCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVE-----------------LV 128
            ....|||.      ||..||||            |.:.|.:. |.:                 ||
  Fly   140 GPSKRNTGKFVNVVCCAGDYCN------------EGDFPELL-PFDSNDVTVITADTSSISKMLV 191

Human   129 GIIAGPVFLLFLI--IIIVFLVINYHQRVYHNRQRLDME-----DPSCEMCLSKDKTLQDLVYDL 186
            .:: ||..::.|:  :.|.|:..::.:|:..:|.:.|.|     |.......:.|.||::.:...
  Fly   192 AVL-GPFLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHS 255

Human   187 STSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIY 251
            .||||||||||.||||:|:.:.|.|.||:|::||||||.|.|..:|||||.||:|.||.||.|||
  Fly   256 VTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIY 320

Human   252 QTVMLRHENILGFIAADNKADCSFLTLPWEVVMVSAAPKLRSLRLQYKGGRGRARFLFPLNNGTW 316
            .|::||||||||||.:|               |.|                          ..:.
  Fly   321 STILLRHENILGFIGSD---------------MTS--------------------------RNSC 344

Human   317 TQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKN 381
            |||||::.|:..|||||:|||..::...|:.:.||.|:||.|||.||.|.||||.:|||||||||
  Fly   345 TQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKN 409

Human   382 ILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYA 446
            |||..||.|.|||.||||.|..||..:|:..|.:||||||||||||||:|:::.|::.:..||||
  Fly   410 ILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRRTDIYA 474

Human   447 LGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMG 511
            .|||.||:.||..|.|:.|||::|:||:||.|||.|:||||||....||:|||.|.|...:..|.
  Fly   475 FGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMS 539

Human   512 KMMRECWYANGAARLTALRIKKTLSQL-SVQEDVKI 546
            |:|:|||:.|...||.|||||||:.:| |..|.:::
  Fly   540 KLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRL 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR1B	NP_064733.3	Activin_recp	32..105	CDD:307282	23/88 (26%)
		TGF_beta_GS	178..205	CDD:312125	16/26 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..539	CDD:271045	169/328 (52%)
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	25/104 (24%)
		TM_EGFR-like	182..218	CDD:213052	7/36 (19%)
		TGF_beta_GS	247..274	CDD:285687	16/26 (62%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	172/337 (51%)
		TyrKc	276..553	CDD:197581	160/317 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820