Protein Alignment ACVR1B and tkv

DIOPT Version :9

• Sequence 1: NP_064733.3
• Gene: ACVR1B / 91
• HGNCID: 172
• Length: 546
• Species: Homo sapiens
• Sequence 2: NP_787990.1
• Gene: tkv / 33753
• FlyBaseID: FBgn0003716
• Length: 575
• Species: Drosophila melanogaster
• Alignment Length: 580
• Identity: 248/580 - (42%)
• Similarity: 319/580 - (55%)
• Gaps: 117/580 - (20%)

Human    23 GSGP----------------RGVQALLCACT-SCLQ--ANYTCET--DGACMVSIFNL----DGM 62
            ||||                ...::|.|.|. ||..  :|.||||  .|:|..::..|    .||
  Fly    56 GSGPGSEGYEDADNEKSKTVENARSLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGM 120

Human    63 EHHVRT--CIP----------KVELVP--AGKPFYCLSSEDLRNTHCCYTDYCNRI-----DLRV 108
            ....||  |:|          ||..||  .||...|...||..|.. .|..|..::     ||.|
  Fly   121 YEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRD-LYPTYTPKLTTPAPDLPV 184

Human   109 PSGHLKEPEHP-SMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQ-RLDMEDPSCEM 171
            .|    |..|. :::|.:    ||:..||:|    |:..|...|.:|....:| ||     ...|
  Fly   185 SS----ESLHTLAVFGSI----IISLSVFML----IVASLCFTYKRREKLRKQPRL-----INSM 232

Human   172 CLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIF 236
            |.|:...|..||.  .:|||||||||.||||:|:.|.:..::||||:||||..:||...||||.|
  Fly   233 CNSQLSPLSQLVE--QSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTF 295

Human   237 SSREERSWFREAEIYQTVMLRHENILGFIAADNKADCSFLTLPWEVVMVSAAPKLRSLRLQYKGG 301
            .:.||.|||||.||||||::||:|||||||||.|
  Fly   296 FTTEEASWFRETEIYQTVLMRHDNILGFIAADIK------------------------------- 329

Human   302 RGRARFLFPLNNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGT 366
                      .||:|||:.|::||||.|||.|||:...:..:.:..||.|.||||||||.||.||
  Fly   330 ----------GNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGT 384

Human   367 QGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETI 431
            .|||.|||||:||||||||:||.|||||.||||::::..|.|.||.|.||||:||||||||.:.:
  Fly   385 PGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQL 449

Human   432 NMKHFDSFKCADIYALGLVYWEIARRCNS--GGVH----EEYQLPYYDLVPSDPSIEEMRKVVCD 490
            :.|.|:.||.||:|::|||.||:.|||.:  .|..    |:|.|||:|:|||||:.|:|..|||.
  Fly   450 DPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCV 514

Human   491 QKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLS----VQEDVKI 546
            :..||.||:.||..:.|..:.|:|:|||:.|...||||||:||||.:|.    :...:||
  Fly   515 KGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRLETDCLIDVPIKI 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR1B	NP_064733.3	Activin_recp	32..105	CDD:307282	31/100 (31%)
		TGF_beta_GS	178..205	CDD:312125	16/26 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..539	CDD:271045	170/333 (51%)
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	30/90 (33%)
		GS	238..266	CDD:197743	17/29 (59%)
		S_TKc	267..557	CDD:214567	166/330 (50%)
		STKc_BMPR1	270..562	CDD:271046	170/332 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144591
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750