DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACVR1B and daf-1

DIOPT Version :9

Sequence 1:	NP_064733.3	Gene:	ACVR1B / 91	HGNCID:	172	Length:	546	Species:	Homo sapiens
Sequence 2:	NP_001023159.1	Gene:	daf-1 / 176829	WormBaseID:	WBGene00000897	Length:	669	Species:	Caenorhabditis elegans

Alignment Length:	567	Identity:	163/567 - (28%)
Similarity:	254/567 - (44%)	Gaps:	141/567 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    45 TCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRID--LR 107
            ||.|||:|..|......:.|                 |.|:..:.:       ||.....|  .:
Worm    89 TCYTDGSCYQSARPSPEISH-----------------FGCMDEKSV-------TDETEFHDTAAK 129

Human   108 VPSGHLKEPEHPSMW---------GPVELVGIIAGP----VFLLFLIIIIVFLVINYHQRVYHNR 159
            |.:.:.|:| |.::|         ....::.:..||    .:|:..|:.::..::.....::..|
Worm   130 VCTNNTKDP-HATVWICCDKGNFCANETIIHLAPGPQQSSTWLILTILALLTFIVLLGIAIFLTR 193

Human   160 QRLDME------------DPSCE------MCLSKD------------------------------ 176
            :..:.:            ||..|      |....|
Worm   194 KSWEAKFDWYIRFKPKPGDPLRETENNVPMVTMGDGAGSSVPEVAPIEQQGSTMSTSAGNSFPPG 258

Human   177 ---KTLQDLVYDL-STSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFS 237
               ..::|::..| .|||||.|.....:.|:...|.|...:|.||||.|.||.:||..||||:|:
Worm   259 IMPNNMKDMLDVLEETSGSGMGPTTLHKLTIGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVKVFN 323

Human   238 SREERSWFREAEIYQTVMLRHENILGFIAADNKADCSFLTLPWEVVMVSAAPKLRSLRLQYKGGR 302
            :.:|.::.:|.||::|.||||.|:|.:|.:| :.|..|:
Worm   324 ALDEPAFHKETEIFETRMLRHPNVLRYIGSD-RVDTGFV-------------------------- 361

Human   303 GRARFLFPLNNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ 367
                          |:||||::||..|||.|:|...||.||....|..|.|||||.||.:|.|::
Worm   362 --------------TELWLVTEYHPSGSLHDFLLENTVNIETYYNLMRSTASGLAFLHNQIGGSK 412

Human   368 --GKPGIAHRDLKSKNILVKKNGMCAIADLGLAVR--HDAVTDTIDIAPNQRVGTKRYMAPEVLD 428
              .||.:||||:|||||:||.:..|||.||||::.  .||.:|.| ...|.:.||.||:|||:|:
Worm   413 ESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDII-ANENYKCGTVRYLAPEILN 476

Human   429 ETINMKHFDSFKCADIYALGLVYWEIARRCNSGGV---HEEYQLPYYDLVPSDPSIEEMRKVVCD 490
            .|:....|:|::|||:|:..||.||...||..|.|   .....:||.:....||...:|..|||.
Worm   477 STMQFTVFESYQCADVYSFSLVMWETLCRCEDGDVLPREAATVIPYIEWTDRDPQDAQMFDVVCT 541

Human   491 QKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQ 537
            ::|||.....|:.:..::.:.::::.||..|.:||.|:...:|.:.:
Worm   542 RRLRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRMDE 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACVR1B	NP_064733.3	Activin_recp	32..105	CDD:307282	12/59 (20%)
		TGF_beta_GS	178..205	CDD:312125	9/27 (33%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..539	CDD:271045	124/334 (37%)
daf-1	NP_001023159.1	GS	265..293	CDD:197743	9/27 (33%)
		Pkinase_Tyr	293..576	CDD:285015	122/324 (38%)
		STKc_TGFbR_I	297..589	CDD:270958	124/334 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161451961
Domainoid	1	1.000	236	1.000	Domainoid score	I1477
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I2302
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm16226
orthoMCL	1	0.900	-	-		OOG6_103647
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.890