Protein Alignment CREB3L1 and CrebA

DIOPT Version :10

• Sequence 1: NP_001412195.1
• Gene: CREB3L1 / 90993
• HGNCID: 18856
• Length: 557
• Species: Homo sapiens
• Sequence 2: NP_524087.3
• Gene: CrebA / 39682
• FlyBaseID: FBgn0004396
• Length: 516
• Species: Drosophila melanogaster
• Alignment Length: 521
• Identity: 156/521 - (29%)
• Similarity: 212/521 - (40%)
• Gaps: 201/521 - (38%)

Human    21 DLGDLNESDFLNNAHFPEHL----DHFTENMEDFSNDLFSSFFDDPVLDEKSPLLDMELDSPTPG 81
            ||.|:.:||.     .||.|    ||   :|.|:   ||.....||.:.....|:...|.:.|..
  Fly     7 DLKDIWDSDL-----DPESLKISPDH---DMHDW---LFDRDVKDPTVILNDKLISDALLNGTQP 60

Human    82 IQAEHSYSLSG--DSAPQSP-LVPIKMED---------TTQDAEHGAWALGHKLCSIMVKQEQSP 134
            |:.|||||||.  ||.|.|| .:..|:||         :.:.|.:|...:..|..:..|....:
  Fly    61 IKTEHSYSLSSDVDSLPDSPKSLQAKIEDMDDECFPAISPKTATNGRVTIDPKYLTFHVPPTHA- 124

Human   135 ELPVDPLAAPSAMAAAAAMATTPLLGLSPLSRLPIPHQAPG---------EMTQLP--------- 181
             .|:..|::..|:..:.|..|.. .||..| :...||...|         |..|||
  Fly   125 -TPISRLSSNPALNTSVADLTRS-SGLQSL-QAHQPHHGSGSSHVVVANLEHFQLPQHLYDNDCS 186

Human   182 ------------------------VIKAEPLEVNQFLKVTP------------------------ 198
                                    .||.||:..:.....:|
  Fly   187 SSVSSLRDGSMSPDICSDIEIDESAIKDEPMSPDSSCPASPTSQASSSQHQLSLNLAHLQSEMLF 251

Human   199 --------------------------------EDLVQ-------------------------MPP 206
                                            ::|:.                         :|.
  Fly   252 EPKHCGLLLTASSNSNNSLIKSQQRQQQILGQDNLLMAKMEIKSEKQSTSNSSDKSHAHGYGIPL 316

Human   207 TPPSSHGS-DSDGSQSPRSL-PPSSP-----------------VRPMARSSTAISTS-------- 244
            |||||..| ||:|:.||..| .|.||                 || ::|::.:|:.|
  Fly   317 TPPSSLPSDDSEGNLSPEHLFAPLSPNATVSISVANPAGGESSVR-VSRTAASITRSSSGSASAS 380

Human   245 -----------------PLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKALK 292
                             ||:::..|  |::|.|||||||||||:|||||||.||||||||||:||
  Fly   381 GSSTSSTVTTTRQPIHTPLISSQPK--GSTGTLLLTEEEKRTLLAEGYPIPQKLPLTKAEEKSLK 443

Human   293 RVRRKIKNKISAQESRRKKKEYVECLEKKVETFTSENNELWKKVETLENANRTLLQQLQKLQTLV 357
            ::||||||||||||||||||||::.||::||...:||::..|::|.||..|..||.||.|||.||
  Fly   444 KIRRKIKNKISAQESRRKKKEYMDQLERRVEILVTENHDYKKRLEGLEETNANLLSQLHKLQALV 508

Human   358 T 358
            :
  Fly   509 S 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CREB3L1	NP_001412195.1	Required for transcriptional activation	1..60		14/42 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	71..98		13/28 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..259		26/127 (20%)
		bZIP_CREB3	291..344	CDD:269837	32/52 (62%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	292..321		23/28 (82%)
		coiled coil	293..344	CDD:269837	30/50 (60%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	332..353		9/20 (45%)
		MBTPS2 recognition. /evidence=ECO:0000303|PubMed:21767813	392..395
		MBTPS1 recognition. /evidence=ECO:0000303|PubMed:21767813	423..426
CrebA	NP_524087.3	bZIP_CREB3	452..502	CDD:269837	28/49 (57%)
		coiled coil	452..495	CDD:269837	24/42 (57%)